Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: An oil deterioration prevention device is provided that can prevent an increase in pressure loss by reducing oilflow resistance. The oil deterioration prevention device may include a filtering unit with a filter element that filters oil, and a deterioration prevention unit having a powdery deterioration prevention agent that prevents deterioration of oil, wherein out of oil fed from an oil containing unit, oil filtered by the filtering unit is fed to a part to be lubricated, and oil that is prevented from being deteriorated by the deterioration prevention unit is returned to the oil containing unit or sent to the part to be lubricated.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: An oil deterioration prevention device is provided that can prevent an increase in pressure loss by reducing oilflow resistance. The oil deterioration prevention device may include a filtering unit including a filter element that filters oil, and a deterioration prevention unit including a powdery deterioration prevention agent that prevents deterioration of oil, wherein the deterioration prevention unit includes a passage wall that retains the deterioration prevention agent and forms an oil passage.

Abstract: The present disclosure provides a jet-black multilayer coating film having excellent properties in high appearance, water resistance, and humidity resistance and comprising a base coating film and a clear coating film formed by a coating composition containing a plant-derived aliphatic polyester mainly and a method for forming the same. A jet-black multilayer coating film comprising a base coating film layer formed by a base coating composition which contains a polyester polyol (A-1) containing a polyol having three or more functions and lactic acid as a consisting component of 80 mol % or more and having a hydroxyl value of 140 to 240 mgKOH/g wherein 70 mol % or more of the hydroxyl groups are secondary hydroxyl groups, an acrylic resin (A-2) with a hydroxyl value of 30 to 80 mgKOH/g and a glass transition point of 40 to 80° C.

Abstract: A battery is composed of a positive electrode in which a positive electrode active material layer including a positive electrode active material is formed on a positive electrode collector, a negative electrode in which a negative electrode active material layer including a negative electrode active material is formed on a negative electrode collector, a separator provided between the positive electrode and the negative electrode, and an electrolyte impregnated in the separator. The battery further includes at least one of a heteropoly acid and a heteropoly acid compound as an additive at least in one of the positive electrode, the negative electrode, the separator, and the electrolyte.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A compound represented by the general formula (III) which serves as an intermediate of an oligonucleotide analog having stable and excellent antisense or antigene activity or having excellent activity as a detection reagent (probe) for a specific gene or as a primer for the initiation of amplification of a specific gene can be produced at high yields regardless of the type of nucleobase by a method comprising reacting a compound represented by the general formula (II) or a salt thereof with a trimethylsilylated compound obtained from a compound represented by the general formula (IVb), wherein X, Y, Z, A, R, and B are as defined in claim 1.

Abstract: An exhaust gas control apparatus for an internal combustion engine, controls an exhaust operation of the internal combustion engine (200) provided with an exhaust gas purification catalyst (216) in an exhaust passage (215). The exhaust gas control apparatus for the internal combustion engine is provided with; a warming-up device configured to warm up the exhaust gas purification catalyst; and an oxygen supplying device (220, 221) configured to supply oxygen to the exhaust gas purification catalyst after the end of the warm-up. This makes it possible to preferably desorb sulfur adsorbed to the exhaust gas purification catalyst during warm-up. It is therefore possible to suppress a reduction in purification ability of the exhaust gas purification catalyst due to sulfur coating.

Abstract: A cathode active material capable of obtaining a high capacity and capable of improving stability or low-temperature characteristics, a method of manufacturing the same, and a battery are provided. A cathode (21) includes a cathode active material including a lithium complex oxide including Li and at least one kind selected from the group consisting of Co, Ni and Mn, and P and at least one kind selected from the group consisting of Ni, Co, Mn, Fe, Al, Mg and Zn as coating elements on a surface of the lithium complex oxide. Preferably, the contents of the coating elements are higher on the surface of the cathode active material than those in the interior thereof, and decrease from the surface to the interior.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L1-L2-LP-NH—(CH2)n1-La-Lb-Lc or -L1-L2-LP- wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the terminal Lc or LP with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2—C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2—C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: When an alcohol mixed fuel is supplied to an internal combustion engine, the magnitude of the alcohol concentration is determined, and the magnitude of an operation state temperature is determined on the basis of the determination. When the alcohol concentration is high and the operation state temperature is low, the generation of intermediate products, which are alcohol oxides contained in unburned alcohol mixed fuel, is promoted, and the intermediate products generated are trapped in an intake passage by opening an intake valve in the expansion stroke of the internal combustion engine.

Abstract: A compound represented by the general formula (III) which serves as an intermediate of an oligonucleotide analog having stable and excellent antisense or antigene activity or having excellent activity as a detection reagent (probe) for a specific gene or as a primer for the initiation of amplification of a specific gene can be produced at high yields regardless of the type of nucleobase by a method comprising reacting a compound represented by the general formula (II) or a salt thereof with a trimethylsilylated compound obtained from a compound represented by the general formula (IVb), wherein X, Y, Z, A, R, and B are as defined in claim 1.

Abstract: An anode includes an anode double side coating section; a first anode single-side coating section; and an anode double side non-coating section, the anode double side non-coating section, the first anode single-side coating section, and the anode double side coating section are provided in this order from a first end on the side of spiral winding start of the anode, and in an anode, (“Area density of an anode mixture layer on the first main surface side of the first anode single-side coating section”)/(“Area density of the anode mixture layer on the first main surface side of sections other than the first anode single-side coating section”) is equal to or more than about 1.2.

Abstract: A cathode active material capable of increasing a capacity and improving high temperature characteristics or cycle characteristics, a method of manufacturing it, a cathode using the cathode active material, and a battery using the cathode active material are provided. In a cathode active material contained in a cathode, a coating layer is provided on at least part of complex oxide particle containing at least lithium (Li) and cobalt (Co). The coating layer is an oxide which contains lithium (Li) and at least one of nickel (Ni) and manganese (Mn).