Abstract: The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RAR?, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond; or a salt thereof.

Abstract: The degree of freedom in design is increased while maintaining strength by enabling a decorative member to be disposed without thinning a wheel main body. A wheel is made up of a wheel main body 1 which is made up of a rim portion 10 and a disc portion 11 and which has a vent hole 141 in the disc portion 11 and a decorative member 2 made from a resin which is held in at least the disc portion 11 and is observed from the vent hole 141. Since the decorative member 2 is observed in the vent hole 141, the wheel main body 1 including spoke portions 14 does not have to be thinned. In addition, since the design of the decorative member is observed in cooperation with the design of the disc portion 11, the degree of freedom in design is increased.

Abstract: The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RAR?, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond; or a salt thereof.

Abstract: Novel bicycloester derivatives and pharmaceutically acceptable salts thereof have high DPP-IV inhibitory activity. The novel bicycloester derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).

Abstract: The degree of freedom in design is increased while maintaining strength by enabling a decorative member to be disposed without thinning a wheel main body. A wheel is made up of a wheel main body 1 which is made up of a rim portion 10 and a disc portion 11 and which has a vent hole 141 in the disc portion 11 and a decorative member 2 made from a resin which is held in at least the disc portion 11 and is observed from the vent hole 141. Since the decorative member 2 is observed in the vent hole 141, the wheel main body 1 including spoke portions 14 does not have to be thinned. In addition, since the design of the decorative member is observed in cooperation with the design of the disc portion 11, the degree of freedom in design is increased.

Abstract: Summary Novel bicycloester derivatives and pharmaceutically acceptable salts thereof have high DPP-IV inhibitory activity. Solving Means The novel bicycloester derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(N-(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).

Abstract: A flat flexible cable connector (10) has a housing (31) with an insertion opening (33) in its front face. Two lengths of flexible cable (51a, 51b) are placed end to end and are inserted into the opening. The connector has terminals (41) with top and bottom opposing contact portions (43a, 44a) which are aligned with the exposed conductive leads on the two lengths of flexible cables. A moveable actuator (11) applies pressure to the terminal contact portions to effect a reliable connection between the flexible cables.

Abstract: A method for predicting preventive and/or therapeutic effect of an RAR-? agonist on a malignant tumor, which comprises the steps of measuring an expression level of a class of p160 family molecule and an expression level of a class of SP110 family molecule in a sample collected from the malignant tumor of a patient, and when the class of the p160 family molecule is dominant in a balance between the expression level of the class of the p160 family molecule and the expression level of the class of the SP110 family molecule, determining that an RAR-? agonist is effective for therapeutic treatment of the malignant tumor of the patient.

Abstract: Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).

Abstract: A process of producing whole wheat flour including the steps of (1) coarsely grinding wheat kernels, (2) separating the resulting ground product into a fine fraction with an average particle size less than a size ranging from 150 to 200 ?m and a coarse fraction with an average particle size more than that of the fine fraction and at or above a size ranging from 150 to 200 ?m, (3) pulverizing the coarse fraction by impact grinding, (4) fractionating the resulting ground product obtained in step (3) to collect a fine fraction with an average particle size less than a size ranging from 150 to 200 ?m, and (5) combining the fine fraction from step (2) and the fine fraction obtained in step (4). Preferably, the coarse fraction obtained in step (2) is subjected to a heat-moisture treatment, and the heat-moisturized fraction is pulverized by impact grinding in step (3).

Abstract: The degree of freedom in design is increased while maintaining strength by enabling a decorative member to be disposed without thinning a wheel main body. A wheel is made up of a wheel main body 1 which is made up of a rim portion 10 and a disc portion 11 and which has a vent hole 141 in the disc portion 11 and a decorative member 2 made from a resin which is held in at least the disc portion 11 and is observed from the vent hole 141. Since the decorative member 2 is observed in the vent hole 141, the wheel main body 1 including spoke portions 14 does not have to be thinned. In addition, since the design of the decorative member is observed in cooperation with the design of the disc portion 11, the degree of freedom in design is increased.

Abstract: The invention relates to the treatment of mammalian diseases manifested by abnormal cell growth and/or abnormal cell proliferation. More particularly, the invention relates to the use of combination therapies to control abnormal cell growth and/or abnormal cell proliferation. In particular, the invention relates to the use of isotype-selective inhibitors of histone deacetylases 1, 2 and/or 3 (HDACs 1-3), as well as isotype-selective inhibitors of HDAC1 and/or HDAC2, to potentiate therapeutic activity of microtubule-stabilization agents.

Abstract: A novel bicyclo derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof, acts as an effective DPP-IV inhibitor: One example is (2S,4S)-1-[[N-(4-methylbicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).

Abstract: A wheel for vehicle includes a wheel body, a decorated member, and a visible space. The wheel body has a rim, a hub, and a plurality of spokes connecting the hub and the rim. The decorated member is made from resin, is disposed on a surface of at least one of the spokes, and is retained to the wheel body. The visible space is disposed between the decorated member and the one of the spokes at least, exhibits a height in an axial direction of the wheel body, and is visible from an axial outer side of the wheel body.

Abstract: A clearance between a metal electrode and a sidewall portion (sidewall) of an approximately U-shaped dielectric is adjusted by, for example, partially inserting a heat insulator, a heat shield or an insulating material. Temperature difference in the Z direction (vertical direction) of the sidewall portion of approximately U-shaped dielectric is made smaller than temperature difference between front and rear sides at the bottom (bottom portion) of approximately U-shaped dielectric, to reduce warp in the Z direction of the sidewall portion of approximately U-shaped dielectric. This curbs warp in the Z direction of the bottom portion of approximately U-shaped dielectric coupled to the sidewall portion. The warp in the Z direction, which would be generated if the temperature difference only between the front and rear surfaces at the bottom were considered, can be curbed by utilizing the sidewall portion of approximately U-shaped dielectric.

Abstract: Novel bicycloester derivatives and pharmaceutically acceptable salts thereof have high DPP-IV inhibitory activity. SOLVING MEANS The novel bicycloester derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).

Abstract: To provide a secure printing system configured such that even if a designated printer is unavailable, printing can be performed with another printer without regard to the difference in models.

Abstract: A plasma processing apparatus according to the present invention includes at least a pair of elongated electrode units which are faced to each other, each electrode unit including an elongated conductive member extending in a longitudinal direction, an elongated dielectric member which is provided on the conductive member in the longitudinal direction, and a fastening member for fastening the conductive member and the dielectric member to each other, wherein the fastening member fastens the conductive member and the dielectric member to each other such that they can displace with respect to each other in the event of the occurrence of thermal expansions of the conductive member and the dielectric member.

Abstract: A method of processing wheat flour that without detriment to secondary processability, improves the flavor and palate feelings thereof, processed wheat flour obtained by the processing method; and fool utilizing the processed wheat flour. The method is characterized in that 10 to 55 pts.wt. of ethyl alcohol is homogeneously dispersed in 100 pts.wt. of wheat flour under such conditions that the total water content is ?20 wt. %, followed by evaporation of ethyl alcohol therefrom at ?50° C.

Abstract: Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).