Patents by Inventor Koji Murakami
Koji Murakami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070249580Abstract: The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPAR? isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: August 11, 2005Publication date: October 25, 2007Inventors: Masahiro Nomura, Yasuo Takano, Kazuhiro Yumoto, Takehiro Shinozaki, Shigeki Isogai, Koji Murakami
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Publication number: 20070167501Abstract: A novel bicyclo derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof, acts as an effective DPP-IV inhibitor: One example is (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).Type: ApplicationFiled: February 22, 2005Publication date: July 19, 2007Inventors: Yasumichi Fukuda, Yoshikazu Asahina, Kazuya Yokota, Koji Murakami, Tomohiro Ide
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Publication number: 20050217798Abstract: The plasma processing apparatus includes main electrodes 5, 31 opposed to each other with a plasma processing space 15 interposed therebetween. The plasma processing apparatus further has a side electrode 6 opposed to side faces 5B-1, 5B-2 of the main electrode 5, as well as a side electrode 32 opposed to side faces 31B-1, 31B-2 of the main electrode 31. Therefore, in addition to the plasma processing space 15 between the main electrode 5 and the main electrode 31, an electric field can be formed in spaces between the side faces of the main electrodes 5, 31 and the side electrodes 6, 32, the spaces serving as predischarge areas 16-1, 16-2. By this electric field, processing gas present in the predischarge areas 16-1, 16-2 can be transformed into plasma. Electrons and excitation species of the plasma generated in these predischarge areas 16-1, 16-2 can be supplied directly to the plasma processing space 15.Type: ApplicationFiled: March 22, 2005Publication date: October 6, 2005Applicant: Sharp Kabushiki KaishaInventors: Akira Sugiyama, Shuhichi Kitamura, Koji Murakami, Daisuke Takahashi, Shohzoh Yoshimoto
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Publication number: 20050205535Abstract: In a welding machine and welding method, for welding cylinder members together about an outside diameter, which prevents the cylinder members from being deformed and corrects the deformation of a portion to be welded, a laser beam, generated by a laser generator, is dispersed in two directions by a spectroscope. The laser beams focus on an outer cylinder member using two optical heads, respectively, in a plane perpendicular to a center axis of outer cylinder member. The optical heads are separated from each other by approximately 90 degrees in the plane. The outer and inner cylinder members are welded to each other in the circular direction using laser beams. Therefore, directions, in which the cylinder members are deformed due to the laser beams, are perpendicular to each other creating uniform radial deformation.Type: ApplicationFiled: May 5, 2005Publication date: September 22, 2005Applicant: DENSO CORPORATIONInventors: Hideaki Shirai, Koji Murakami, Norio Tanaka, Yoshiki Kariya, Hiroyuki Nishina, Takayuki Hokao
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Patent number: 6919528Abstract: In a welding machine and welding method, for welding cylinder members together about an outside diameter, which prevents the cylinder members from being deformed and corrects the deformation of a portion to be welded, a laser beam, generated by a laser generator, is dispersed in two directions by a spectroscope. The laser beams focus on an outer cylinder member using two optical heads, respectively, in a plane perpendicular to a center axis of outer cylinder member. The optical heads are separated from each other by approximately 90 degrees in the plane. The outer and inner cylinder members are welded to each other in the circular direction using laser beams. Therefore, directions, in which the cylinder members are deformed due to the laser beams, are perpendicular to each other creating uniform radial deformation.Type: GrantFiled: February 25, 2002Date of Patent: July 19, 2005Assignee: Denso CorporationInventors: Hideaki Shirai, Koji Murakami, Norio Tanaka, Yoshiki Kariya, Hiroyuki Nishina, Takayuki Hokao
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Patent number: 6780431Abstract: The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by a general formula (1) wherein R1 denotes a chlorine atom, bromine atom, nitro group, trifluoromethoxy group, ethoxy group, propoxy group or isopropoxy group, and R2 denotes a hydrogen atom or chlorine atom, their medicinally acceptable salts, their hydrates and a process for preparing them.Type: GrantFiled: February 20, 2002Date of Patent: August 24, 2004Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Mashiro Nomura, Koji Murakami, Masaki Tsunoda, Yukie Takahashi
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Patent number: 6762171Abstract: The invention creates a very high-novelty medicinal drug for the carbohydrate and lipid metabolism-related diseases by finding out an inhibitory substance or antagonist against PPAR &agr; and PPAR &ggr;, and relates to an application of fatty acid CoA thioester that was found out as an active inhibitory substance against peroxisome proliferator-activated receptor &agr; and &ggr; (hereinafter referred to as PPARs) to the assay of medicinal drug, and a use of fatty acid CoA thioester for medicinal drug.Type: GrantFiled: May 30, 2002Date of Patent: July 13, 2004Assignee: Kyorin Pharmaceutical Co, Ltd.Inventors: Koji Murakami, Tomohiro Ide, Toshiro Mochizuki, Takashi Kadowaki
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Patent number: 6734199Abstract: The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.Type: GrantFiled: February 20, 2002Date of Patent: May 11, 2004Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Koji Murakami, Masaki Tsunoda
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Patent number: 6730687Abstract: The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives that bind to receptor to activate as ligands of human peroxisome proliferator-activated receptor (PPAR) and exhibit blood glucose-decreasing action and lipid-decreasing action, and processes for preparing them. It relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein the bond mode of A denotes —CH2CONH—, —NHCONH—, —CH2CH2CO— or —NHCOCH2—, and B denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, halogen atom, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and processes for preparing them.Type: GrantFiled: February 25, 2002Date of Patent: May 4, 2004Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Koji Murakami, Masaki Tsunoda
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Patent number: 6706763Abstract: O-anisamide compounds and their addition salts effective for the prevention and/or therapy of metabolic diseases such as hyperlipidemia and diabetes, in which peroxisome proliferator-activated receptor (PPAR) being intranuclear receptor, in particular, human PPAR participates, as agonistic drugs thereon, and processes for preparing them, wherein the o-anisamide compounds are represented by a general formula (1) [wherein R denotes a carboxyl group, carboxymethyl group or CH2CHXCOY (here X denotes a mercapto group or S(O)nMe (n=0, 1 or 2) and Y denotes an amino group or hydroxyl group)], their medicinally acceptable salts, and their hydrates.Type: GrantFiled: March 18, 2002Date of Patent: March 16, 2004Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Hiroya Satoh, Masakatsu Komuro, Koji Murakami, Katsuya Awano
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Patent number: 6582013Abstract: In a structure for assembling lamps 30 to 32 and a wire harness for those lamps onto a body ceiling 2 of a vehicle body 1, the lamps 30 to 32 and the wire harness for the lamps are assembled to a sub-frame 25 in advance, and electrically connected to each other in advance. In the assembling work, the sub-frame 25 is assembled to the body ceiling 2 of the vehicle body 1, whereby the lamps 30 to 32 and the wire harness for the lamps are assembled to the body ceiling 2 by one assembling work.Type: GrantFiled: November 7, 2000Date of Patent: June 24, 2003Assignees: Autonetworks Technologies, Ltd., Sumitomo Wiring Systems, Ltd., Sumitomo Electric Industries, Ltd.Inventors: Takuya Inoue, Yasuyo Matsumoto, Nobutaka Hamanishi, Koji Murakami
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Patent number: 6545026Abstract: The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a pyridyl group or cyclohexyl group], their medicinally acceptable salts, their hydrates and a process for preparing them.Type: GrantFiled: February 20, 2002Date of Patent: April 8, 2003Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Shizuyoshi Fujimori, Koji Murakami, Masaki Tsunoda
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Patent number: 6506797Abstract: The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor &agr; (PPAR&agr;), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). It relates to a substituted phenylpropanoic acid derivatives represented by a general formula (1), their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.Type: GrantFiled: December 10, 2001Date of Patent: January 14, 2003Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Masahiro Nomura, Yukie Takahashi, Takahiro Tanase, Hiroyuki Miyachi, Masaki Tsunoda, Tomohiro Ide, Koji Murakami
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Publication number: 20020117561Abstract: In a welding machine and welding method, for welding cylinder members together about an outside diameter, which prevents the cylinder members from being deformed and corrects the deformation of a portion to be welded, a laser beam, generated by a laser generator, is dispersed in two directions by a spectroscope. The laser beams focus on an outer cylinder member using two optical heads, respectively, in a plane perpendicular to a center axis of outer cylinder member. The optical heads are separated from each other by approximately 90 degrees in the plane. The outer and inner cylinder members are welded to each other in the circular direction using laser beams. Therefore, directions, in which the cylinder members are deformed due to the laser beams, are perpendicular to each other creating uniform radial deformation.Type: ApplicationFiled: February 25, 2002Publication date: August 29, 2002Inventors: Hideaki Shirai, Koji Murakami, Norio Tanaka, Yoshiki Kariya, Hiroyuki Nishina, Takayuki Hokao
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Patent number: 6325611Abstract: A non-aqueous secondary cell comprising a wound structure, in which a positive electrode having a positive collector carrying positive active material on both sides at least at a part of the collector and a negative electrode having a negative collector carrying a negative active material on both sides at least at a part of the collector are wound with inserting a separator inbetween, and a cell can for holding said electrodes, in which the electrode, which faces the can, consists of either electrode material, the outer side of the positive collector at least in the outermost part of the positive electrode has no coating film containing a positive active material, said outer most part of the positive collector faces the negative electrode or the inner wall of the cell can through the separator, and a lead member which is welded to the negative collector does not directly face the positive electrode through the separator.Type: GrantFiled: July 9, 1999Date of Patent: December 4, 2001Assignee: Hitachi Maxell, Ltd.Inventors: Minako Iwasaki, Hayato Higuchi, Hiroki Ishikawa, Koji Murakami, Fusaji Kita, Kazunobu Matsumoto
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Patent number: 6147101Abstract: The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.Type: GrantFiled: January 13, 2000Date of Patent: November 14, 2000Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Toshio Maeda, Masahiro Nomura, Katsuya Awano, Susumu Kinoshita, Hiroya Satoh, Koji Murakami, Masaki Tsunoda
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Patent number: 6048713Abstract: A novel Pseudomonas fluorescens is disclosed which has an antagonist property against pathogenic fungi of the genera Pythium, Rhizoctonia, Sclerotinia and Gaeumannomyces and which has a DNA that forms a PCR product band at about 800 bp when replicated and amplified by PCR using a primer DNA having the base sequence of 5'-GGCAACTGCACAAGCGCCA (SEQ ID NO: 1) and a primer DNA having the base sequence of 5'-GCCAATCACGCCCTCAAGCT (SEQ ID NO: 2) and then electrophoresed on agarose gel. This microorganism can also promote the growth of plants. A material for controlling pathogenic fungi of plants, particularly, lawn grass, a plant growth promoting material and a compost comprising the microorganism are also disclosed.Type: GrantFiled: March 27, 1997Date of Patent: April 11, 2000Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Koji Murakami, Akiko Kudo, Hideaki Yamada, Ken Kanzaki, Kenzo Okada
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Patent number: 6030990Abstract: The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.Type: GrantFiled: December 2, 1997Date of Patent: February 29, 2000Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Toshio Maeda, Masahiro Nomura, Katsuya Awano, Susumu Kinoshita, Hiroya Satoh, Koji Murakami, Masaki Tsunoda
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Patent number: 6001862Abstract: The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.Type: GrantFiled: April 16, 1999Date of Patent: December 14, 1999Assignee: Kyorin Pharameuticals Co., Ltd.Inventors: Toshio Maeda, Masahiro Nomura, Katsuya Awano, Susumu Kinoshita, Hiroya Satoh, Koji Murakami, Masaki Tsunoda
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Patent number: 5948803Abstract: The invention provides novel N-substituted dioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic effect and lipid-lowering effect, and the process for preparing them, and relates to N-substituted dioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## ?wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms or hydroxyl groups, or R.sup.1 and R.sup.2 combine to form a methylenedioxy group, R.sup.3 denotes a hydrogen atom, lower alkoxys group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, R.sup.4 denotes a hydrogen or lower alkyl group with carbon atoms of 1 to 3, n denotes an integer of 0 to 2, and X denotes N or CH!, and process for preparing the same.Type: GrantFiled: June 16, 1998Date of Patent: September 7, 1999Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Toshio Maeda, Masahiro Nomura, Katsuya Awano, Susumu Kinoshita, Hiroya Satoh, Koji Murakami, Masaki Tsunoda