Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and pharmaceutical compositions containing the cyclic peptide compounds or salts thereof, or solvates thereof.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: A glass member for a housing of an electronic device may include an aluminosilicate glass substrate defining a first surface of the glass member, the first surface having a first surface roughness, a fused composite coating bonded to a portion of the aluminosilicate glass substrate and defining a second surface of the glass member, the second surface having a second surface roughness greater than the first surface roughness, a first ion-exchanged layer extending into the glass member and through the fused composite coating, and a second ion-exchanged layer extending into the glass member from the first surface. The fused composite coating may include an amorphous glass matrix and a crystalline material dispersed in the amorphous glass matrix.

Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: A martensitic stainless steel containing, by mass %, C: 0.20% to 0.40%, N: 0.1% or less, Mo: 3% or less, and Cr: 12.0% to 16.0%, such that 0.3%?C+N?0.4% and a PI value (=Cr+3.3Mo+16N) is 18 or more, with the remainder being substantially Fe and unavoidable impurities is quenched from a temperature of 1,030° C. to 1,140° C. and subjected to a subzero treatment and tempering so as to obtain a prior austenite crystal grain size of a surface layer of 30 ?m to 100 ?m and a surface hardness of 58 HRc to 62 HRc.

Abstract: A glass member for a housing of an electronic device may include an aluminosilicate glass substrate defining a first surface of the glass member, the first surface having a first surface roughness, a fused composite coating bonded to a portion of the aluminosilicate glass substrate and defining a second surface of the glass member, the second surface having a second surface roughness greater than the first surface roughness, a first ion-exchanged layer extending into the glass member and through the fused composite coating, and a second ion-exchanged layer extending into the glass member from the first surface. The fused composite coating may include an amorphous glass matrix and a crystalline material dispersed in the amorphous glass matrix.

Abstract: A martensitic stainless steel containing, by mass %, C: 0.20% to 0.40%, N: 0.1% or less, Mo: 3% or less, and Cr: 12.0% to 16.0%, such that 0.3%?C+N?0.4% and a PI value (=Cr+3.3Mo+16N) is 18 or more, with the remainder being substantially Fe and unavoidable impurities is quenched from a temperature of 1,030° C. to 1,140° C. and subjected to a subzero treatment and tempering so as to obtain a prior austenite crystal grain size of a surface layer of 30 ?m to 100 ?m and a surface hardness of 58 HRc to 62 HRc.

Abstract: A martensitic stainless steel containing, by mass %, C: 0.20% to 0.40%, N: 0.1% or less, Mo: 3% or less, and Cr: 12.0% to 16.0%, such that 0.3%?C+N?0.4% and a PI value (=Cr+3.3 Mo+16 N) is 18 or more, with the remainder being substantially Fe and unavoidable impurities is quenched from a temperature of 1,030° C. to 1,140° C. and subjected to a subzero treatment and tempering so as to obtain a prior austenite crystal grain size of a surface layer of 30 ?m to 100 ?m and a surface hardness of 58 HRc to 62 HRc.

Abstract: A liquid discharging apparatus includes a liquid discharging head that discharges a liquid from a nozzle, a control circuit that controls a discharge operation of the liquid discharging head, a nozzle omission detection mechanism that detects a discharge fault of the nozzle, a maintenance mechanism that performs a maintenance operation, which ejects the liquid from the nozzle of the liquid discharging head, and a display device that displays a setting screen relating to the discharge operation of the liquid discharging head. The control circuit executes the discharge operation of the liquid discharging head on the basis of the operation mode selected by a user using the operation mode selection screen for selecting a plurality of operation modes in which a situation in which a transition to the maintenance operation is performed in a case in which the discharge fault is detected, differs, on the display device.

Abstract: A liquid discharging apparatus includes a liquid discharging head that discharges a liquid from a nozzle, a control circuit that controls a discharge operation of the liquid discharging head, a nozzle omission detection mechanism that detects a discharge fault of the nozzle, a maintenance mechanism that performs a maintenance operation, which ejects the liquid from the nozzle of the liquid discharging head, and a display device that displays a setting screen relating to the discharge operation of the liquid discharging head. The control circuit executes the discharge operation of the liquid discharging head on the basis of the operation mode selected by a user using the operation mode selection screen for selecting a plurality of operation modes in which a situation in which a transition to the maintenance operation is performed in a case in which the discharge fault is detected, differs, on the display device.

Abstract: There is provided a portable terminal including: a first battery; a second battery having a thermal capacity smaller than the first battery; a switch configured to switch an electric power supply to electronic components between the first battery and the second battery; a memory; and a processor coupled to the memory and the processor configured to control the switch so that the second battery supplies electric power to the electronic components when the portable terminal is started.

Abstract: Inspection processing is performed. The inspection processing includes a first driving step of driving a piezoelectric element corresponding to an inspection target nozzle, a first detection step of detecting vibration that is generated in ink in a pressure chamber corresponding to the inspection target nozzle by the driving in the first driving step, a second driving step of driving together the piezoelectric element corresponding to the inspection target nozzle and a piezoelectric element corresponding to at least one nozzle of nozzles adjacent to the inspection target nozzle, and a second detection step of detecting vibration that is generated in the ink in the pressure chamber corresponding to the inspection target nozzle by the driving in the second driving step.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: A martensitic stainless steel containing, by mass %, C: 0.20% to 0.40%, N: 0.1% or less, Mo: 3% or less, and Cr: 12.0% to 16.0%, such that 0.3%?C+N?0.4% and a PI value (=Cr+3.3Mo+16N) is 18 or more, with the remainder being substantially Fe and unavoidable impurities is quenched from a temperature of 1,030° C. to 1,140° C. and subjected to a subzero treatment and tempering so as to obtain a prior austenite crystal grain size of a surface layer of 30 ?m to 100 ?m and a surface hardness of 58 HRc to 62 HRc.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: Inspection processing is performed. The inspection processing includes a first driving step of driving a piezoelectric element corresponding to an inspection target nozzle, a first detection step of detecting vibration that is generated in ink in a pressure chamber corresponding to the inspection target nozzle by the driving in the first driving step, a second driving step of driving together the piezoelectric element corresponding to the inspection target nozzle and a piezoelectric element corresponding to at least one nozzle of nozzles adjacent to the inspection target nozzle, and a second detection step of detecting vibration that is generated in the ink in the pressure chamber corresponding to the inspection target nozzle by the driving in the second driving step.

Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.

Abstract: A drive signal includes a first drive signal and a second drive signal. The first drive signal includes a prior pulse section including a first contraction element and a discharging pulse section including a first expansion element pulling in a meniscus and the second contraction element discharging a droplet of liquid from the nozzle orifice. The second drive signal includes the discharging pulse section and a vibration control pulse section including a second expansion element controlling a residual vibration of the meniscus. A piezoelectric element is driven with the first drive signal when viscosity of the liquid is equal to or more than a first set value and is driven with the second drive signal when the viscosity is equal to or less than a second set value.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.