Abstract: The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 ?m to 20 ?m, and an opening coverage ratio of the through-holes is from 30% to 70%.

Abstract: A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

Abstract: A microchannel device includes: a channel unit which is configured of a plurality of channel members which are laminated in a thickness direction to define a microchannel, at least one of the channel members being made of a material having elasticity; and a holding member which is provided separately from or integrally with the channel unit and holds the channel unit in a state of being compressed in the thickness direction.

Abstract: Provided is a method for producing a cell laminate including cell layers on both surfaces of a porous membrane, using a vessel having a bottom portion and a side wall portion standing from a periphery of the bottom portion, the porous membrane, and a holding member configured to hold the porous membrane such that the porous membrane faces an inner bottom surface of the vessel and is held at a position that does not contact the inner bottom surface, the method including culturing first cells in a liquid medium that contacts the inner bottom surface of the vessel and a surface of the porous membrane, in a state in which the porous membrane is held, by the holding member, at a position that does not contact the inner bottom surface of the vessel so as to face the inner bottom surface, and in which the bottom portion of the vessel is positioned at the upper side while the porous membrane is positioned at the lower side in a direction of gravity; and culturing the first cells at a lower surface of the porous membr

Abstract: There is provided a conductive film having conductivity in a surface direction, being deformable, having excellent durability, and transmitting visible light. A conductive film includes a film substrate and a conductive material layer. The conductive material layer is provided on a first substrate surface of the film substrate. A plurality of through holes penetrating the film substrate and the conductive material layer in a thickness direction are formed in the conductive film. The conductive material layer has a plurality of conductive portions, and the conductive portions are present between adjacent layer opening portions. The number of the conductive portion is 400 per 1 mm2, and an opening ratio of the conductive material layer is at least 40%.

Abstract: Provided are a method for producing a cell tissue, including a culturing step of culturing cells capable of serving as a feeder inside opening pores and communicating pores of a porous film having a plurality of the opening pores provided on a surface thereof and the communicating pores communicating mutually adjacent opening pores with one another; and a porous film including a plurality of opening pores provided on a surface thereof and communicating pores communicating mutually adjacent opening pores with one another.

Abstract: Provided are a lubricating material which is made of a non-fluorine-based compound and thus has a surface that is slippery enough for liquid such as water or oil, a lubricant-holding base material which holds a fluorine-based lubricant and thus can be used as a lubricating material, and methods for producing the same. A slippery film has a holding base and a lubricant. The holding base has pillar structure portions and fluorine-containing portions, and the fluorine-containing portions are provided on outer surfaces of a plurality of pillar portions in the pillar structure portion. The lubricant is a fluorine-based liquid, and the fluorine-containing portion has a C—F bond. The lubricant is loaded into a region surrounded by a plurality of the pillar portions and is held in this region.

Abstract: The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 ?m to 20 ?m, and an opening coverage ratio of the through-holes is from 30% to 70%.

Abstract: A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

Abstract: There is provided a conductive film having conductivity in a surface direction, being deformable, having excellent durability, and transmitting visible light. A conductive film includes a film substrate and a conductive material layer. The conductive material layer is provided on a first substrate surface of the film substrate. A plurality of through holes penetrating the film substrate and the conductive material layer in a thickness direction are formed in the conductive film. The conductive material layer has a plurality of conductive portions, and the conductive portions are present between adjacent layer opening portions. The number of the conductive portion is 400 per 1 mm2, and an opening ratio of the conductive material layer is at least 40%.

Abstract: Provided is a composite binder material, a cell aggregate, a cell accumulation method, a cell preservation method, and a method of manufacturing a composite binder that can supply oxygen and nutrients to cells. A composite binder material comprises a binder material and a cell non-adhesive portion. A binder material formed in a membrane shape is provided between a first cell sheet and a second cell sheet. The cell non-adhesive portion formed at least in a portion of one membrane surface and/or other membrane surface of the binder material. A plurality of pores are formed in the binder material, and the pores open to the one membrane surface coming into contact with one sheet surface of the first cell sheet. The pores penetrate in a thickness direction and a surface direction along the one membrane surface. The porosity of the binder material is set to be at least 50%.

Abstract: Provided are a lubricating material which is made of a non-fluorine-based compound and thus has a surface that is slippery enough for liquid such as water or oil, a lubricant-holding base material which holds a fluorine-based lubricant and thus can be used as a lubricating material, and methods for producing the same. A slippery film has a holding base and a lubricant. The holding base has pillar structure portions and fluorine-containing portions, and the fluorine-containing portions are provided on outer surfaces of a plurality of pillar portions in the pillar structure portion. The lubricant is a fluorine-based liquid, and the fluorine-containing portion has a C—F bond. The lubricant is loaded into a region surrounded by a plurality of the pillar portions and is held in this region.

Abstract: Disclosed is a film which is able to suppress agglutination by being continuously adhered to an adhesion target portion in a biological body while suppressing a position shift. A film includes an adhesive and an adhesion inhibiting layer. The adhesive layer absorbs and maintains a liquid in a plurality of pores which are opened in one film surface and has a capillary force for adhering the adhesive layer to a first-cell group. The adhesive layer is formed of a biodegradable polymer. The adhesion inhibiting layer configures the other film surface, and inhibits adhesion between a second-cell group which is different from the first-cell group and the adhesive layer. In the adhesive layer, the pore is formed not to be penetrated in a thickness direction of the film, and thus the first-cell group and the second-cell group are separated into the one film surface side and the other film surface side.

Abstract: Film, which has a fine structure and is adhered to various materials in an easy and strong manner without an adhesive agent, and a composite structure, film laminate, producing method and etching method, are provided. Solution in which a hydrophobic high molecular compound and a catechol group-containing compound are dissolved in solvent is cast, to form cast film. Dew is condensed on an uncovered surface of the cast film. The solvent and water droplets upon the condensation are evaporated from the cast film, to produce porous film. The porous film has a honeycomb structure in which plural pores are formed in one film surface. The pores are in a substantially equal shape and size, and are arranged regularly at a constant pitch. The film surface on a side having the pores of the porous film is a functional surface having an adhesive property.

Abstract: A protrusion/recess structure in which fine particles will not drop easily and which will not be deformed easily is provided, and a producing method for the same is provided. In the protrusion/recess structure (porous film), protrusions or recesses (fine corrugations) are formed in a surface. The protrusion/recess structure is formed from plural fine particles and an amphipathic high molecular compound having a catechol group. The high molecular compound at least partially coats a surface of the fine particles, to adhere the fine particles to one another. A diameter of the recesses is larger than a diameter of the fine particles. Cast film is formed from solution containing the fine particles and the high molecular compound having the catechol group. Condensation on the cast film is performed, and organic solvent and water droplets created by the condensation are evaporated to produce the protrusion/recess structure.

Abstract: A solution of polymer uniformly dissolved into a solvent is prepared in a solution preparing step. The solvent contains good and poor solvent components for the polymer. The solution is discharged from a coating die to a support to be a coating film thereon in a primary body forming step. A water drop generating step and a fluidity decreasing step are performed in parallel with each other while wet air is applied to the coating film. Water drops are generated on a surface of the coating film in the water drop generating step. The good solvent component is evaporated from the coating film to decrease fluidity of the solution for forming the coating film in the fluidity decreasing step. In the water drop evaporating step, dry air is applied to the coating film. The solvent and the water drops are evaporated from the coating film to obtain the porous film.

Abstract: A composite film comprises a drug sustained-release portion and an adhesive portion which are layered on each other. The drug sustained-release portion has film-like drug layers and a film-like biodegradable polymer layer. The drug sustained-release portion has the drug layer, the biodegradable polymer layer, and the drug layer in this order from the adhesive portion side. Each drug layer is a drug form containing a drug of a predetermined concentration or more. The drug is released from the drug layer exposed. When the drug layer disappears, a biodegradable polymer of the biodegradable polymer layer starts to degrade and/or dissolve. When the biodegradable polymer layer disappears, the drug is released from the drug layer adjoining the adhesive portion. A plurality of pores are formed in the adhesive portion. The pores retain water due to capillary force.

Abstract: In a coating zone, a cylindrical tube is soaked in and taken out from a solution, such that a coating film is formed on a curved surface of the tube. In a wet gas zone, while a first gas feeding nozzle having a gas outlet moves in a state where the gas outlet faces an outer peripheral surface of the tube, wet gas is blown toward the coating film through the gas outlet. Water drops are generated on the coating film and grown up. In a dry gas zone, as in the case of the first gas feeding nozzle, while a second gas feeding nozzle having a gas outlet moves, dry gas is blown toward the coating film through the gas outlet. Solvent and water drops are evaporated from the coating film. Pores form from the water drops as a template for the porous material on the coating film.

Abstract: After a second liquid is applied to a support and dried, a first liquid is applied thereon. On a film of the first liquid, a third liquid (water) is supplied in droplets using an inkjet-type liquid supply unit. An area supplied with the droplets is referred to as porous area. Next, an organic solvent is evaporated from the film and the droplets are evaporated from the porous area. Thus, a porous film is obtained. The porous film has the porous areas in which a plurality of pores are arranged. Since the droplets are directly formed by an inkjet printing method, a condensation process and a droplet growing process are unnecessary. Thus, the porous film is produced efficiently. Shapes of the porous areas can be changed easily. The porous areas can be formed on the porous film in various patterns.

Abstract: A hydrophobic liquid containing a dispersion medium and fine particles is prepared. The fine particles have insolubility of a certain level in a predetermined liquid having a hydrophobic character. The hydrophobic liquid is applied to a support to be a film thereon. Wet gas is blown to the film. Water vapor is condensed from ambient air on a surface of the film to generate water drops thereon. A dispersion medium evaporating gas is blown to the film, such that the dispersion medium is evaporated from the film. A water drop evaporating gas is blown to the film, such that the water drops are evaporated from the film. Accordingly, the water drops function as the template for forming pores, such that the pores are formed on a micro protrusion-depression structure constituted by the fine particles.