Patents by Inventor Kornelija Zgonc
Kornelija Zgonc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230122742Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample.Type: ApplicationFiled: October 28, 2022Publication date: April 20, 2023Inventors: Gordon A. JANAWAY, Mark ANDERSEN, Kornelija ZGONC, Michael C. PALLAS, Marcin SIKORA, Casey R. McFARLAND, Ferrier N. LE, Haopeng Wang, Jian GONG, Gothami Padmabandu
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Patent number: 11235323Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: GrantFiled: August 30, 2019Date of Patent: February 1, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Joseph Amshey, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Thacker, Timothy Updyke, Kornelija Zgonc
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Publication number: 20200224280Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample.Type: ApplicationFiled: January 13, 2020Publication date: July 16, 2020Inventors: Gordon A. JANAWAY, Mark ANDERSEN, Kornelija ZGONC, Michael C. PALLAS, Marcin SIKORA, Casey R. McFARLAND, Ferrier N. LE, Haopeng Wang, Jian GONG, Gothami Padmabandu
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Publication number: 20200197934Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: ApplicationFiled: August 30, 2019Publication date: June 25, 2020Inventors: Joseph AMSHEY, Daniel BEZDEK, Espir KAHATT, Alexander KHORLIN, Lance PARSONS, Todd PETERSON, Timothy POWERS, Michael THACKER, Timothy UPDYKE, Kornelija ZGONC
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Patent number: 10557174Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample.Type: GrantFiled: March 25, 2016Date of Patent: February 11, 2020Assignee: Life Technologies CorporationInventors: Gordon A. Janaway, Mark Andersen, Kornelija Zgonc, Michael C. Pallas, Marcin Sikora, Casey R. McFarland, Ferrier N. Le, Haopeng Wang, Jian Gong, Gothami Padmabandu
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Patent number: 10434509Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: GrantFiled: September 28, 2017Date of Patent: October 8, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Joseph Amshey, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Thacker, Timothy Updyke, Kornelija Zgonc
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Publication number: 20180111121Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: ApplicationFiled: September 28, 2017Publication date: April 26, 2018Inventors: Joseph AMSHEY, Daniel BEZDEK, Espir KAHATT, Alexander KHORLIN, Lance PARSONS, Todd PETERSON, Timothy POWERS, Michael THACKER, Timothy UPDYKE, Kornelija ZGONC
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Patent number: 9808799Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: GrantFiled: August 19, 2014Date of Patent: November 7, 2017Assignee: Life Technologies CorporationInventors: Joseph Amshey, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Thacker, Timothy Updyke, Kornelija Zgonc
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Publication number: 20160208342Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample.Type: ApplicationFiled: March 25, 2016Publication date: July 21, 2016Inventors: Gordon A. Janaway, Mark Andersen, Kornelija Zgonc, Michael C. Pallas, Marcin Sikora, Casey R. McFarland, Ferrier N. Le, Haopeng Wang, Jian Gong, Gothami Padmabandu
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Patent number: 9322055Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample.Type: GrantFiled: March 30, 2012Date of Patent: April 26, 2016Assignee: Life Technologies CorporationInventors: Gordon A. Janaway, Mark Andersen, Kornelija Zgonc, Michael Pallas, Marcin Sikora, Casey McFarland, Ferrier N. Le, Haopeng Wang, Jian Gong, Gothami Padmabandu
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Patent number: 9227199Abstract: The present disclosure relates to a magnetizing portion for providing a high-gradient magnetic field in a magnetic separation device. The magnetizing portion comprises at least one magnetic assembly. The at least one magnetic assembly comprises: a plurality of magnets whereby each magnet has a north pole, south pole and a magnet axis extending between the north and south poles, and the plurality of magnets are arranged one above the other in a direction at least substantially perpendicular to the axis of each magnet in such a manner that the north and south poles of adjacent magnets are arranged alternately and a space is provide between adjacent magnets; and at least one non-magnetic spacing means arranged in the space between adjacent magnets. The present disclosure also relates to magnetic separation devices comprising at least one of the said magnetizing portions and to a method of isolating magnetically labelled particles using the magnetic separation devices.Type: GrantFiled: May 29, 2008Date of Patent: January 5, 2016Assignee: Life Technologies ASInventors: Darren Ellis, Tine Borgen Hildisch, Jeremy Mundy, Erlend Ragnhildstveit, Richard Johan Toften, Kornelija Zgonc, Malin Karlsson, Gaute Brede, Lars Noekleby
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Patent number: 9199247Abstract: The disclosure relates to a magnetic separation rack for isolating magnetically labeled particles from a non-magnetic medium comprising a body portion (1) and a foot portion (8). The body portion comprises an array of sample vessel retaining portions (2) and plurality of magnetizing portions (3). Each sample vessel retaining portion comprises at least one visible portion such that when a sample vessel is mounted in a sample vessel retaining portion at least one portion of the sample vessel is visible to a user. The magnetizing portions are arranged within the body portion (1) such that at least two magnetizing portions (3) are circumferentially spaced about each sample vessel retaining portion (2). The foot portion is pivotally coupled to the body portion such that the body portion is operatively tiltable with respect to the foot portion such that each sample vessel retaining portion may retain a sample vessel mounted therein in a tilted position with respect to the vertical.Type: GrantFiled: May 29, 2008Date of Patent: December 1, 2015Assignee: Invitrogen Dynal ASInventors: Darren Ellis, Tine Borgen Hildisch, Jeremy Mundy, Erlend Ragnhildstveit, Richard Johan Toften, Kornelija Zgonc
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Patent number: 9011772Abstract: Provided herein is a bioprocessing device, bioprocessing card, and fluidics cartridge for performing automated bioprocessing of a sample. The bioprocessing card may include a plurality of pipette tips; and at least one pump in fluid communication with the plurality of pipette tips. In some embodiments, the pumps and the pipette tips are in fluid communication through a processing channel which may be a microscale channel. Also provided herein is an automated bioprocessing device comprising: at least one bioprocessing card; at least one fluidic cartridge; and an automated control system configured to control automated bioprocessing of a sample. Further provided herein are methods of use of the device, card, and cartridge.Type: GrantFiled: May 11, 2010Date of Patent: April 21, 2015Assignee: Life Technologies CorporationInventors: Lars Norderhaug, Morten Egeberg, Tommy Rivrud, Lars Nokleby, Espir Kahatt, Jamie Hogan, Kornelija Zgonc, Norman Trolson
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Publication number: 20150044758Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: ApplicationFiled: August 19, 2014Publication date: February 12, 2015Inventors: Joseph Amshey, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Thacker, Timothy Updyke, Kornelija Zgonc
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Patent number: 8845984Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: GrantFiled: September 13, 2012Date of Patent: September 30, 2014Assignee: Life Technologies CorporationInventors: Joseph Amshey, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Thacker, Timothy Updyke, Kornelija Zgonc
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Publication number: 20140248623Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample.Type: ApplicationFiled: March 30, 2012Publication date: September 4, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Gordon A. Janaway, Mark Andersen, Kornelija Zgonc, Michael Pallas, Marcin Sikora, Casey McFarland, Ferrier N. Le, Haopeng Wang, Jian Gong, Gothami Padmabandu
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Patent number: 8574515Abstract: The disclosure relates to a magnetic separating device for isolating magnetically labelled particles from a non-magnetic medium comprising a body portion (1) having a magnetising portion (3) for providing a magnetic field and a surface by means of which the body portion may stand on a supporting surface; and a sample vessel retaining portion (4) for retaining at least one sample vessel (5), wherein, the magnetising portion (3) is configured to conform at least approximately to at least a substantial portion of the longitudinal profile of at least one sample vessel (5); the sample vessel retaining portion (4) is configured to retain at least one sample vessel (5) such that at least a portion of the contents of the sample vessel (5) is visible to a user; and the sample vessel retaining portion (4) is configured to be mountable on the magnetising portion so that in use, the at least one sample vessel is subject to the magnetic field of the magnetising portion (3).Type: GrantFiled: May 29, 2008Date of Patent: November 5, 2013Assignee: Life Technologies ASInventors: Darren Ellis, Tine Borgen Hildisch, Jeremy Mundy, Erlend Ragnhildstveit, Richard Johan Toften, Kornelija Zgonc, Gaute Brede, Lars Noekleby
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Publication number: 20130040376Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.Type: ApplicationFiled: September 13, 2012Publication date: February 14, 2013Applicant: LIFE TECHNOLOGIES COPORATIONInventors: Joseph AMSHEY, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Tacher, Timothy Updyke, Kornelija Zgonc
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Patent number: D743533Type: GrantFiled: March 25, 2011Date of Patent: November 17, 2015Assignee: Invitrogen Dynal ASInventors: Gaute Brede, Darren Ellis, Tine Hildisch, Jez Mundy, Lars Nokleby, Erlend Ragnhildstveit, Richard Toften, Kornelija Zgonc
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Patent number: RE46207Type: GrantFiled: May 9, 2013Date of Patent: November 22, 2016Assignee: LIFE TECHNOLOGIES ASInventors: Gaute Brede, Darren Ellis, Tine Hildisch, Jeremy (“Jez”) Mundy, Lars Nokleby, Erlend Ragnhildstveit, Richard Toften, Kornelija Zgonc