Patents by Inventor Kota Ramana

Kota Ramana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
    Publication number: 20070021366
    Abstract: Provided herein is a crystallized ternary structure of aldose reductase (AR) bound to NADPH and ?-glutamyl-S-(1,2-dicarboxyethyl)cysteinylglycine (DCEG). Also provided are specific inhibitors of glutathione-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary AR:NADPH:DCEG structure and methods of designing and of screening the inhibitors for inhibition of glutathione-aldehyde binding to aldose reductase. In addition methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway using a small interfering RNA (siRNA) or the designed inhibitors.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 25, 2007
    Inventors: Satish Srivastava, Kota Ramana
  • Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
    Publication number: 20060110814
    Abstract: Provided herein is a crystallized ternary structure of aldose reductase (AR) bound to NADPH and ?-glutamyl-S-(1,2-dicarboxyethyl)cysteinylglycine (DCEG). Also provided are specific inhibitors of glutathione-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary AR:NADPH:DCEG structure and methods of designing and of screening the inhibitors for inhibition of glutathione-aldehyde binding to aldose reductase.
    Type: Application
    Filed: November 18, 2005
    Publication date: May 25, 2006
    Inventors: Satish Srivastava, Aurni Bhatnagar, Kota Ramana