Abstract: The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

Abstract: The invention provides a pharmaceutical combination including an ?v?1 integrin inhibitor and at least one additional therapeutic agent for preventing, delaying or treating liver diseases or disorders. The additional therapeutic agent may be an SGLT1/2 inhibitor, among a diverse selection of agents. For example, the pharmaceutical combination includes (S)-2-(4-methyltetrahydro-2H-pyran-4-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) nonanoic acid (Compound 1) and at least one additional therapeutic agent.

Abstract: The invention provides a pharmaceutical combination including an ?v?1 integrin inhibitor and at least one additional therapeutic agent for preventing, delaying or treating liver diseases or disorders. The at least one additional therapeutic agent may be a farnesoid X receptor (FXR) agonist. For example, the pharmaceutical combination includes (S)-2-(4-methyltetrahydro-2H-pyran-4-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid (Compound 1) and 2-[3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1, 3-ben-zothiazole-6-carboxylic acid (tropifexor).

Abstract: Techniques described herein generally relate to etching graphene. The techniques can include disposing graphene on a patterned substrate, applying a resist to the graphene on the patterned substrate, curing the resist, and etching exposed portions of the graphene. Graphene composites including patterned substrates, graphene disposed on the patterned substrate, and a resist disposed on the graphene, are disclosed. Systems configured to perform the methods and/or make the graphene composites are also disclosed.

Abstract: The present technology provides a carbon fiber reinforced plastic that includes carbon fibers covalently bonded to an energetic polymer and a polymer matrix. Also described is a method for recycling carbon fibers from the carbon fiber reinforced plastic material using microwave energy to separate the carbon fibers from the polymer matrix.

Abstract: Technologies are generally described for gas filtration and detection devices. Example devices may include a graphene membrane and a sensing device. The graphene membrane may be perforated with a plurality of discrete pores having a size-selective to enable one or more molecules to pass through the pores. A sensing device may be attached to a supporting permeable substrate and coupled with the graphene membrane. A fluid mixture including two or more molecules may be exposed to the graphene membrane. Molecules having a smaller diameter than the discrete pores may be directed through the graphene pores, and may be detected by the sensing device. Molecules having a larger size than the discrete pores may be prevented from crossing the graphene membrane. The sensing device may be configured to identify a presence of a selected molecule within the mixture without interference from contaminating factors.

Abstract: Techniques described herein are generally related to graphene membranes having gas-permeable substrates. Various example substrates may include a gas-permeable substrate with a convoluted surface and a graphene layer on the gas-permeable substrate. The membranes may also include nanopores formed on the graphene layer. The membranes may exhibit improved permeability properties. Methods and systems configured to make and use the membranes are also disclosed.

Abstract: Techniques described herein generally relate to etching graphene. The techniques can include disposing graphene on a patterned substrate, applying a resist to the graphene on the patterned substrate, curing the resist, and etching exposed portions of the graphene. Graphene composites including patterned substrates, graphene disposed on the patterned substrate, and a resist disposed on the graphene, are disclosed. Systems configured to perform the methods and/or make the graphene composites are also disclosed.

Abstract: The present technology provides a carbon fiber reinforced plastic that includes carbon fibers covalently bonded to an energetic polymer and a polymer matrix. Also described is a method for recycling carbon fibers from the carbon fiber reinforced plastic material using microwave energy to separate the carbon fibers from the polymer matrix.

Abstract: The present technology provides a carbon fiber reinforced plastic that includes carbon fibers covalently bonded to an energetic polymer and a polymer matrix. Also described is a method for recycling carbon fibers from the carbon fiber reinforced plastic material using microwave energy to separate the carbon fibers from the polymer matrix.

Abstract: Technologies are generally described for a gas filtration device including an array of parallel carbon nanotubes. The carbon nanotubes may extend between first and second substrates, and the ends of the carbon nanotubes may be embedded in the substrates and cut to expose openings at each end of the carbon nanotubes. The carbon nanotubes may be composed from a graphene membrane which may be perforated with a plurality of discrete pores of a selected size for enabling one or more molecules to pass through the pores. A fluid mixture including two or more molecules for filtering may be directed through the first openings of the array of nanotubes, and the fluid mixture may be filtered by enabling smaller molecules to pass through the discrete pores of the graphene membrane walls of the carbon nanotubes to produce in a filtrate fraction including the smaller molecules and a retentate fraction including larger molecules.

Abstract: Systems and articles of manufacture for minimizing corrosion in supercritical water gasification components are disclosed, as well as methods for their preparation and operation. The systems may include a nonconducting conduit that is configured to receive a fluid at a first end and transmit the fluid toward a second end thereof. The fluid may include a plurality of ions. The nonconducting conduit may include an inside surface and an outside surface. The systems may further include a plurality of electrodes distributed about at least a portion of the outside surface of the nonconducting conduit and a power source electrically connected to the plurality of electrodes. The power source may be configured to apply an alternating current across the plurality of electrodes, and the alternating current may be effective to exert an electrophoretic force on the plurality of ions in the fluid.

Abstract: Technologies are generally provided for thermostatic packaging materials for packing temperature sensitive products such as foods, beverages, biological materials, pharmaceuticals, vaccines, and live organisms. The thermostatic packaging materials may be formed from a number of substrates in which thermo-responsive capsules may be suspended. The substrates may be composed from a gelatin film substrate in some examples. The thermo-responsive capsules may encapsulate a cooling agent for reducing a surrounding environmental temperature. The thermo-responsive capsules may be composed from a polymer such as poly N-isopropylacrylamide (PNIPAAm), which may be configured to release the encapsulated cooling agents when the surrounding environmental temperature reaches a threshold temperature.

Abstract: Technologies are presented for selecting an electrode gain value for applying electricity to control a combustion reaction. For example, a system can include one or more electrodes, an electrode gain selector configured to select an operative electrode gain value for the one or more electrodes, and a power supply operatively coupled to the one or more electrodes. The power supply can be configured to apply the electricity to the combustion reaction via the one or more electrodes at the operative electrode gain value.

Abstract: Latent fluorescent tags, including compounds of Formula I, methods of making latent fluorescent tags, and methods of fluorescently labeling living cells are provided. The compounds of Formula I have the structure: wherein each of the variables are as defined herein.

Abstract: Methods of treating wood including modifying a cell wall of the wood to be positively charged to form a cationic wood cell wall; and contacting a negatively charged silicon layer to the cationic wood cell wall to form a barrier, wherein the negatively charged silicon layer includes a silicate ester group, a silinol group, a silicon oxide group or a combination thereof are described. Treated wood compositions including a wood structure having an outer layer including a wood cell having a cell wall attached to a silicon layer which includes a silicate ester group, a silinol group, a silicon oxide group or a combination thereof are also described.

Abstract: A dioxirane-containing compound has a first substituent that is an alkyl, polyalkoxy, aryl, heteroaryl, or heterocyclyl group, and a second substituent that is an electron withdrawing group, and where the first and second substituents can optionally join to form a cycloalkyl or heterocyclyl group. The dioxirane-containing compound can be used as an oxidant, surfactant, and/or an ionic liquid.

Abstract: Disclosed are methods and kits pertaining to detecting live bacterial pathogens using sortase enzymes and reflective spectroscopy such as reflective interferometry.

Abstract: The present technology provides an carbon fiber reinforced plastic having an organoamine coated carbon fiber and a carbonyl functionalized matrix polymer. Also described is a method for recycling the carbon fiber reinforced plastic using an acidic gas.

Abstract: Latent fluorescent tags, including compounds of Formula I, methods of making latent fluorescent tags, and methods of fluorescently labeling living cells are provided. The compounds of Formula I have the structure: wherein each of the variables are as defined herein.