Abstract: Described herein are injectable or infusible formulations of PARP inhibitors. In one aspect, the formulation comprises a PARP inhibitor and a cyclodextrin. The injectable or infusible PARP inhibitor-cyclodextrin formulation improves drug solubility, bioavailability, and therapeutic effectiveness. Also described herein are methods for treating oncological and non-oncological indications with injectable or infusible formulations of PARP inhibitors.

Abstract: Described herein are injectable or infusible formulations of PARP inhibitors. In one aspect, the formulation comprises a PARP inhibitor and a cyclodextrin. The injectable or infusible PARP inhibitor-cyclodextrin formulation improves drug solubility, bioavailability, and therapeutic effectiveness. Also described herein are methods for treating oncological and non-oncological indications with injectable or infusible formulations of PARP inhibitors.

Abstract: Systems and methods for determining relationships between key performance indicators (KPIs) associated with a healthcare product are disclosed. A method includes receiving information identifying a set of KPIs associated with a healthcare product, determining a hierarchy of the set of KPIs, determining directional effects between the set of KPIs, based on the hierarchy, determining, using structural equation modeling, values of the directional effects, providing the values of the directional effects, and performing a resource allocation action based on the values of the directional effects.

Abstract: Provided herein are methods for iodinating biomolecules, including proteins and peptides. The methods can be used to successfully and efficiently iodinate biomolecules under relatively mild reaction conditions. As a consequence, the methods described herein can be used to iodinate biomolecules that include, for example, an oxidatively unstable moiety (e.g., an optical dye) without adversely impacting the oxidatively unstable moiety.

Abstract: The present disclosure provides a system and method for providing live streaming of video data. The system includes: a storage unit to store a plurality of waiting to transmit a set of multimedia data signals from one I-frame to next I-frame; an index assignment unit to assign an index number to each multimedia data signal to be transmitted; a latency calculating unit to calculate latency count in transmission upon transmission of the set of multimedia data signals such that a predefined condition is checked, by a conditioning unit; a transmitting unit adapted to transmit the set of multimedia data signals, I-frames, inter-coded frames (P-frames) based on calculated latency count; and an elimination unit configured to, when the latency count is equal to the predefined condition, eliminate at least same number of un-transmitted P-frames prior to an immediate next I-frame waiting to be transmitted in the storage unit.

Abstract: The present disclosure provides a system and method for providing live streaming of video data. The system includes: a storage unit to store a plurality of waiting to transmit a set of multimedia data signals from one I-frame to next I-frame; an index assignment unit to assign an index number to each multimedia data signal to be transmitted; a latency calculating unit to calculate latency count in transmission upon transmission of the set of multimedia data signals such that a predefined condition is checked, by a conditioning unit; a transmitting unit adapted to transmit the set of multimedia data signals, I-frames, inter-coded frames (P-frames) based on calculated latency count; and an elimination unit configured to, when the latency count is equal to the predefined condition, eliminate at least same number of un-transmitted P-frames prior to an immediate next I-frame waiting to be transmitted in the storage unit.

Abstract: Provided herein are methods for iodinating biomolecules, including proteins and peptides. The methods can be used to successfully and efficiently iodinate biomolecules under relatively mild reaction conditions. As a consequence, the methods described herein can be used to iodinate biomolecules that include, for example, an oxidatively unstable moiety (e.g., an optical dye) without adversely impacting the oxidatively unstable moiety.

Abstract: The present invention relates to an induction supply air terminal device where primary air flow is used to induce a secondary air flow wherein the nozzles are provided in the form of a cluster arrangement, comprising one or more clusters of three or more nozzles each. The clusters can be arranged according to predetermined patterns depending on the pattern of air induction that is desired.

Abstract: A method of storing configuration data for mobile computing devices can comprise the steps of providing a master configuration file including one or more parameter records and providing a device file including one or more device records. Each parameter record can map a parameter value to a parameter identifier. Each device record can map a parameter identifier to a mobile computing device identifier.

Abstract: A method of storing configuration data for mobile computing devices can comprise the steps of providing a master configuration file including one or more parameter records and providing a device file including one or more device records. Each parameter record can map a parameter value to a parameter identifier. Each device record can map a parameter identifier to a mobile computing device identifier.

Abstract: The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

Abstract: Methods and systems are provided for managing a model-based design lifecycle having a plurality of stages. The system comprises an input interface for receiving input from the user of the system, a display device, and a processor coupled to the input interface and the display device. The processor is configured to display a user interface on the display device, wherein the user interface comprises a plurality of controls that each corresponds to a different process associated with a stage of the model-based design lifecycle. Certain ones of the controls are configured to require the user to perform the corresponding processes in a required order and certain other ones of the controls are arranged to encourage the user to perform the corresponding operation in a preferred order. The processor is also configured to retrieve a software module for each selected control to implement the corresponding process.

Abstract: The present invention provides a process for the preparation of p-toluic acid by liquid phase oxidation of p-xylene using oxygen or air as oxidant in the presence of p-toluic acid, water as solvent and cobalt salt or its combinations with salts of Ce, Mn as catalyst. Oxidation is carried out at 130-190° C. and pressure sufficient to keep water in liquid state. Oxidation step is followed by filteration to obtain p-toluic acid as major product. Untreated p-xylene is recovered and recycled and the catalyst is recovered from aqueous phase and is recycled.

Abstract: When a mobile node suffers an abrupt shut down while operating in a foreign network and recovers in its home network, the present invention enables the mobile node to reestablish communication capability, without time delay, with the nodes that had established one or more communication sessions with the mobile node prior to the abrupt shut down. The mobile node of the present invention includes an update module that determines whether additional information needs to be sent to the nodes in communication with the mobile node prior to the mobile node suffering an abrupt shut down. Based on that determination, the update module may provide additional information to such nodes.

Abstract: A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient, Xm[X?(L?)]n, which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safety in that it is able to scavenge both free metal ions and free organic ligand.

Abstract: This invention provides for antiparasitical agents and methods for treating, preventing and controlling external parasites in animals.

Abstract: The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

Abstract: The present invention provides a process for the preparation of p-toluic acid by liquid phase oxidation of p-xylene using oxygen or air as oxidant in the presence of p-toluic acid, water as solvent and cobalt salt or its combinations with salts of Ce, Mn as catalyst. Oxidation is carried out at 130-190° C. and pressure sufficient to keep water in liquid state. Oxidation step is followed by filteration to obtain p-toluic acid as major product. Unreacted p-xylene is recovered and recycled and the catalyst is recovered from aqueous phase and is recycled.

Abstract: This invention provides for inter alia, topical anthelmintic formulations which comprise a pharmaceutically active combination consisting of at least one macrocyclic compound and at least one compound selected from the group consisting of praziquantel, morantel and pyrantel, which are dissolved in a non-aqueous solvent or solvent mixture and optionally a thickening agent.

Abstract: This invention provides for antiparasitical agents and methods for treating, preventing and controlling external parasites in animals.