Abstract: The invention generally discloses coronavirus vaccine for coronavirus disease. Particularly, the invention discloses coronavirus vaccine through nasal immunization. More particularly, the invention describes and develop a preventive vaccine against infection or disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through nasal immunization in mammals. Specifically, the invention describes human adenovirus which is engineered to express SARS-CoV-2 spike protein or part/fragment thereof which elicit immune response against the SARS-CoV-2 in mammals, and it is also suitable for immunizing human subjects. Describes the method of production of novel adenovirus vectors, use thereof in vaccine composition, vaccine formulation, preparation, and method of treatment of COVID-19 using above said novel vectors and compositions thereof.

Abstract: Modified-release pharmaceutical compositions of ruxolitinib or a pharmaceutically acceptable salt thereof are disclosed. Preferably, the invention relates to oral modified-release pharmaceutical compositions of ruxolitinib, which enable once-daily administration. Oral modified-release compositions of ruxolitinib, methods for their administration, processes for their preparation, and use of these compositions for treatment of diseases treatable by ruxolitinib are also described.

Abstract: A system includes a database that stores a database table and at least one processor configured to detect a trigger event that triggers extending of a current data partitioning definition defined for partitioning data stored in the database table, obtain a partition configuration to extend the current data partitioning definition, obtain the current data partitioning definition of the database table, generate a new data partitioning definition for the database table based on the current data partitioning definition and the partition configuration, and perform data partitioning for the database table based on the new data partitioning definition.

Abstract: The present disclosure is concerned with ?-carboline adducts and dimer compounds comprising two ?-carboline moieties and methods of synthesizing the same. The methods described herein may also be used to synthesize a wide array of ?-carboline adducts and dimer compounds, depending upon the reactants used. Generally, the method comprises reacting a tryptamine and an acid chloride or diacid chloride in acetonitrile to yield harmaline compounds which can be easily converted to harmine or tetrahydroharmine if desired.

Abstract: Methods, systems, and devices for wireless communications for opportunistic sounding for low latency applications are described. An access point (AP) may communicate with one or more stations (STAs), and may communicate a control message indicating more than one periodic service periods for wireless communication with the one or more STAs. The AP may transmit, via a transmit beam, a data message during a first service period of the more than one periodic service periods based on a first compressed beamforming estimate (CBF) for the transmit beam being satisfactory for the first service period and transmit one or more sounding signals during the first service period after transmitting the data message based on the first CBF being suboptimal for a second service period that occurs after the first service period. The STA(s) may transmit, and the AP may receive, an indication of a second CBF based on the one or more sounding signals.

Abstract: Provided herein are rigid macrocycles comprising a poly(peri-naphthalene) diimide (PPNDI) submit and a second diimide subunit having both high photoluminescent and electron accumulation activities. Also provided herein are methods of preparation of the rigid macrocycles and methods of using the same.

Abstract: Systems, methods, and computer-readable media for requesting a cellular IP address by initiating a call with a modem, establishing data packet network connectivity with the cellular IP address, assigning the cellular IP address to a virtual L2-bridge interface, wherein the virtual L2-bridge interface includes a MAC address, mapping a MAC address of a virtual machine with the MAC address of the virtual L2-bridge interface, detecting a change in the cellular IP address, and updating the virtual L2-bridge interface with a different cellular IP address while maintaining the data packet network connectivity.

Abstract: A computing device may determine an occurrence of a network event associated with a pair of network devices of a plurality of network devices included in a network. The computing device may, in response to determining the occurrence of the network event, determine a plurality of network parameters associated with the network. The computing device may determine, using a plurality of decision trees and based on the plurality of network parameters, a number of overlay tunnels to add between the pair of network devices. The computing device may create the number of overlay tunnels over an underlay topology of the network between the pair of network devices.

Abstract: Methods, apparatus, and processor-readable storage media for implementing extensible upgrade and modification as a service are provided herein. An example computer-implemented method includes processing one or more modifiers, wherein each modifier includes an independent processing unit having a given canonical structure and is configured to execute one or more automated actions related to at least one of application modification and application migration; obtaining data pertaining to multiple applications across multiple computing environments; determining, based at least in part on processing at least a portion of the obtained data, at least one of the one or more modifiers applicable for use in executing at least one of the one or more automated actions in connection with at least a portion of the multiple applications; and executing the at least one of the one or more automated actions using the at least one determined modifier.

Abstract: Disclosed herein are lithiated cyclodextrin metal organic frameworks and method of making and using the same. A metal organic framework comprising a coordinated network of repeating units extending in three dimensions, wherein the repeating unit comprises a cyclodextrin, a first coordinating metal cation, and a second coordinating metal cation.

Abstract: A system and a method of classifying data and providing an accuracy of classification are described. The method includes determining values of statistical features associated with data packets present in a data stream. The values of statistical features are provided to a data model for producing a classification output including the data packets classified into one or more categories. While producing the classification output, the data model extracts heuristics for each of the values of statistical features, compares the heuristics with one or more conditional checks defined at each node within the data model, and determines a cumulative score based on results of the comparing. The cumulative score is determined by aggregating a score assigned to successful clearance of each conditional check. The cumulative score indicates an accuracy of the classification output.

Abstract: A code remediation system accesses a programming code including vulnerabilities such as potential secrets and remediates at least a subset of the potential secrets to generate modified programming code wherein the subset of potential secrets which are determined to be actual secrets are replaced with access mechanisms to storage locations on a vault wherein the actual secrets are secured. To identify the subset of potential secrets forming the actual secrets to be remediated, the code remediation system is configured to filter out false positives among the potential secrets and identify true positives. When an application executing the modified code encounters an access mechanism, it accesses the vault to retrieve the actual secrets.

Abstract: Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.

Abstract: Systems and methods are provided for controlling gaming moments across different gaming channels, different entities, and different environments. In one example, the system and methods use blockchain and/or non-fungible token (NFT) components and/or functionality. In an embodiment, a computing system can detecting a qualifying game event for a sharable gaming moment. The computing system generates a digital asset. The digital asset indicates details of the qualifying game event. The computing system encodes a referral code with the digital asset. The computing system transmits, in response to a user input via an application of a user computing device, the digital asset and the referral code to at least one gaming channel. The computing system detects, in response to electronic communication from the at least one gaming channel, an action associated with the digital asset. The computing system awards, based on the referral code and the action, a number of points for use (e.g.

Abstract: The invention relates to novel agonist vaccine formulation, wherein the agonist is novel TLR7/8 agonist which is used as an adjuvant or an immunomodulator. More particularly, the invention relates to the preparation of vaccine formulations against viral infections using Algel-IMDG as an adjuvant. The invention also relates to development of vaccine formulations for severe viral infections using the novel Algel-IMDG as an adjuvant that comprises TLR 7/8 agonist chemisorbed on to surface of Aluminium hydroxide gel. The invention also relates to the use of novel Algel-IMDG formulation as an adjuvant in Vaccine composition against several other viral diseases like Covid-19 caused by SARS-CoV-2 either wild type or its variants, Japanese Encephalitis, recombinant Hepatitis B surface antigen etc.

Abstract: The present invention relates to a tablet for oral administration containing valsartan and sacubitril, preferably as sodium salts or as a complex of valsartan disodium and sacubitril monosodium, preferably LCZ696. The tablet is prepared by dry-granulation or direct compression and contains a mesoporous inorganic stabilizer, e.g. mesoporous silica (Syloid®).

Abstract: A controller device manages a plurality of network devices arranged at a plurality of sites. The controller device includes one or more processing units configured to determine a stateful intent for managing a software application at the plurality of network devices and represented by a graph model and translate the stateful intent into low-level configuration data. The one or more processing units are further configured to determine, for each site, a priority index based on a site-level usage of the software application, determine, an ordered list of the plurality of sites based on the priority index for each respective site, and configure, for each respective site, and in an order specified by the ordered list of the plurality of sites, one or more network devices of the plurality of network devices that are arranged at the respective site according to the low-level configuration data.

Abstract: A fractional sampling-rate converter includes a first-in first-out (FIFO) buffer, a write logic, a read logic and a fractional interpolator. The write logic is designed to write input data samples into the FIFO at a first rate. The fractional interpolator is coupled to receive the input data samples from the FIFO and is designed to generate corresponding interpolated data samples as an output of the fractional sampling-rate converter at a second rate. The read logic is designed to cause input data samples in the FIFO buffer to be transferred to the fractional interpolator. A ratio of the second rate and the first rate is a fractional number greater than one.

Abstract: Systems and methods are provided for collecting data related to changes to a data store table, which may be used for analyzing problems that occur in the network. The information monitored may include types of changes made to a data store/table, such as insertions and deletions of data store elements. When an anomaly occurs in the statistical data store/table data, an alert is issued. This statistical data of the types of changes to a data store may be suggestive of similar changes in a network. For example, the uptime, inactive time, and stable time of rows of a data store table may be used for estimating or inferring the uptime, inactive time, and stable time for nodes, data paths, or other elements of a network. The system may include a web UI or a command line interface, which may aid in diagnosing problems in the network, and taking corrective action.

Abstract: A system for representing objects in a surrounding environment of a vehicle using a Frenet coordinate system. The system includes a memory and an electronic processor. The electronic processor is in communication with the memory and configured to, receive, from one or more sensors, input regarding one or more objects in the surrounding environment. The input includes, for each of the one or more objects, a representation of a location of the object in Cartesian coordinates. The electronic processor is further configured to convert the location of each object from Cartesian coordinates to Frenet coordinates and store the location of each object in Frenet coordinates in the memory.