Abstract: The invention relates to novel agonist vaccine formulation, wherein the agonist is novel TLR7/8 agonist which is used as an adjuvant or an immunomodulator. More particularly, the invention relates to the preparation of vaccine formulations against viral infections using Algel-IMDG as an adjuvant. The invention also relates to development of vaccine formulations for severe viral infections using the novel Algel-IMDG as an adjuvant that comprises TLR 7/8 agonist chemisorbed on to surface of Aluminium hydroxide gel. The invention also relates to the use of novel Algel-IMDG formulation as an adjuvant in Vaccine composition against several other viral diseases like Covid-19 caused by SARS-CoV-2 either wild type or its variants, Japanese Encephalitis, recombinant Hepatitis B surface antigen etc.

Abstract: The present invention relates to a tablet for oral administration containing valsartan and sacubitril, preferably as sodium salts or as a complex of valsartan disodium and sacubitril monosodium, preferably LCZ696. The tablet is prepared by dry-granulation or direct compression and contains a mesoporous inorganic stabilizer, e.g. mesoporous silica (Syloid®).

Abstract: A controller device manages a plurality of network devices arranged at a plurality of sites. The controller device includes one or more processing units configured to determine a stateful intent for managing a software application at the plurality of network devices and represented by a graph model and translate the stateful intent into low-level configuration data. The one or more processing units are further configured to determine, for each site, a priority index based on a site-level usage of the software application, determine, an ordered list of the plurality of sites based on the priority index for each respective site, and configure, for each respective site, and in an order specified by the ordered list of the plurality of sites, one or more network devices of the plurality of network devices that are arranged at the respective site according to the low-level configuration data.

Abstract: A fractional sampling-rate converter includes a first-in first-out (FIFO) buffer, a write logic, a read logic and a fractional interpolator. The write logic is designed to write input data samples into the FIFO at a first rate. The fractional interpolator is coupled to receive the input data samples from the FIFO and is designed to generate corresponding interpolated data samples as an output of the fractional sampling-rate converter at a second rate. The read logic is designed to cause input data samples in the FIFO buffer to be transferred to the fractional interpolator. A ratio of the second rate and the first rate is a fractional number greater than one.

Abstract: Systems and methods are provided for collecting data related to changes to a data store table, which may be used for analyzing problems that occur in the network. The information monitored may include types of changes made to a data store/table, such as insertions and deletions of data store elements. When an anomaly occurs in the statistical data store/table data, an alert is issued. This statistical data of the types of changes to a data store may be suggestive of similar changes in a network. For example, the uptime, inactive time, and stable time of rows of a data store table may be used for estimating or inferring the uptime, inactive time, and stable time for nodes, data paths, or other elements of a network. The system may include a web UI or a command line interface, which may aid in diagnosing problems in the network, and taking corrective action.

Abstract: A system for representing objects in a surrounding environment of a vehicle using a Frenet coordinate system. The system includes a memory and an electronic processor. The electronic processor is in communication with the memory and configured to, receive, from one or more sensors, input regarding one or more objects in the surrounding environment. The input includes, for each of the one or more objects, a representation of a location of the object in Cartesian coordinates. The electronic processor is further configured to convert the location of each object from Cartesian coordinates to Frenet coordinates and store the location of each object in Frenet coordinates in the memory.

Abstract: A system includes a database that stores a database table and at least one processor configured to detect a trigger event that triggers extending of a current data partitioning definition defined for partitioning data stored in the database table, obtain a partition configuration to extend the current data partitioning definition, obtain the current data partitioning definition of the database table, generate a new data partitioning definition for the database table based on the current data partitioning definition and the partition configuration, and perform data partitioning for the database table based on the new data partitioning definition.

Abstract: Systems, methods, and computer-readable media for requesting a cellular IP address by initiating a call with a modem, establishing data packet network connectivity with the cellular IP address, assigning the cellular IP address to a virtual L2-bridge interface, wherein the virtual L2-bridge interface includes a MAC address, mapping a MAC address of a virtual machine with the MAC address of the virtual L2-bridge interface, detecting a change in the cellular IP address, and updating the virtual L2-bridge interface with a different cellular IP address while maintaining the data packet network connectivity.

Abstract: The present disclosure provides a stable, ready-to-dilute injectable pharmaceutical composition comprising trabectedin and at least one pharmaceutically acceptable excipient, wherein the composition is free of ethanol.

Abstract: A pharmaceutical composition comprising a tannin selected from 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-?-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-?-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-?-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-?-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-?-D-glucose. The tannin may be derived from Quercus infectoria. The pharmaceutical composition is used in a method of treating cancer, particularly oral cancer.

Abstract: Systems, methods, and computer-readable media for requesting a cellular IP address by initiating a call with a modem, establishing data packet network connectivity with the cellular IP address, assigning the cellular IP address to a virtual L2-bridge interface, wherein the virtual L2-bridge interface includes a MAC address, mapping a MAC address of a virtual machine with the MAC address of the virtual L2-bridge interface, detecting a change in the cellular IP address, and updating the virtual L2-bridge interface with a different cellular IP address while maintaining the data packet network connectivity.

Abstract: The present invention relates to modified-release pharmaceutical compositions of ruxolitinib or its pharmaceutically acceptable salts thereof. Preferably, the invention relates to oral modified-release pharmaceutical compositions of ruxolitinib, which enable once-daily administration. The present invention further relates to oral modified-release compositions of ruxolitinib, methods for their administration, processes for their preparation, and use of these compositions for treatment of diseases treatable by ruxolitinib.

Abstract: The present invention relates to a stable formulation of cyclophosphamide comprising a therapeutically effective amount of cyclophosphamide, ethanol as solvent, polyethylene glycol as the solvent, and optionally, monothioglycerol as the anti-oxidant, wherein the composition is stable over its shelf life.

Abstract: The present invention relates to a sterile, ready-to-use, aqueous composition of bortezomib that is stable over its shelf life.

Abstract: System, method, and device for controlling a vehicle. In one example, the system includes an electronic processor configured to capture, via a camera, a first image, determine, within the first image, a road traffic factor, and generate, based on sensor information from one or more sensors of the vehicle, a second image depicting an environment surrounding the vehicle. The second image includes the road traffic factor. The electronic processor is also configured to, determine, based on the detected road traffic factor and the second image, a predicted trajectory of a traffic participant proximate to the vehicle, and generate a steering command for the vehicle based on the predicted trajectory.

Abstract: Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.

Abstract: A system and a method for performing programmable analytics on network data are described. A data layer constructs flow behavior information based on information present within headers of data packets flowing across one or more network devices configured in a computer network. An inline heuristics layer performs one or more inline heuristic operations on the flow behavior information to obtain aggregate statistical information. An integrated analytics layer performs one or more analytical operations on the flow behavior information to obtain network insights. A presentation layer filters and plots information obtained from the data layer, the inline heuristics layer, and the integrated analytics layer, based on a user input.

Abstract: The treatment of human subjects suffering from COVID-19 comprises the step of administering to the human subjects a medicament selected from the group consisting of 1,3-bis(7-methoxy-4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)propane, and/or the isomers, tautomers, enantiomers, esters, derivatives, metal complexes, prodrugs, solvates, metabolites, and pharmaceutically acceptable salts thereof. The medicament may also be contacted with SARS-CoV-2 virus for inhibition of the virus.

Abstract: A system and method for managing items for fulfilment of an order in a warehouse are provided. The method comprises retrieving, at one instance, at least one item of the one or more items associated with an order being processed; scanning the items to generate a scan information therefor; assigning one of storage bins of a plurality of storage bins to the order being processed based on the acquired scan information; one of one or more sorting robots, provided on one or more platform levels to collect the said at least one item and transfer the said at least one item to the assigned storage bin to the order being processed; and transferring the said assigned storage bin to a packaging station in the warehouse, when each of the one or more items associated with the order being processed are transferred to the said assigned storage bin.

Abstract: A method comprises collecting message-oriented-middleware system parameters from a plurality of message-oriented-middleware clusters, analyzing the parameters using one or more machine learning algorithms, and predicting, based at least in part on the analyzing, at least one anomaly in a message-oriented-middleware cluster of the plurality of message-oriented-middleware clusters. In the method, message metadata is collected from the message-oriented-middleware cluster, and at least part of the message metadata is transmitted to one or more remaining ones of the plurality of message-oriented-middleware clusters. At least the part of the message metadata corresponds to messaging operations to be transferred from the message-oriented-middleware cluster to the one or more remaining ones of the plurality of message-oriented-middleware clusters.