Abstract: A method for imaging an array of microspheres. The method employs a wavelength tunable light source and camera for detecting and quantifying the presence of biological probes that indicate the presence of specific chemical moieties within a biological system.

Abstract: A specular light source and camera for detecting and quantifying the presence of biological probes, which contain a colorant with spectral properties that depend upon the angle of illumination and angle of imaging, that indicate the presence of specific chemical moieties within a biological system.

Abstract: A method for imaging an array of microspheres. A light source, filter or combination of filters that isolate wavelength, or wavelength ranges, of light and a camera are used for detecting and quantifying the presence of biological probes that indicate the presence of specific chemical moieties within a biological system.

Abstract: The present invention relates to a bistable polymer dispersed liquid crystal display comprising a support, at least one patterned first conductor layer having thereon at least one dried imaging layer comprising a substantial monolayer of isolated domains of liquid crystal material dispersed in a continuous polymer matrix, wherein said dried imaging layer further comprises at least one absorber colorant, and wherein said isolated domains have a size distribution such that the coefficient of variation (cv) is less than 0.35.

Abstract: The present invention relates to a display comprising at least one substrate, at least one electrically conductive layer and at least one electronically modulated imaging layer, wherein the electronically modulated imaging layer comprises a self-assembled, close-packed, ordered monolayer of domains of electrically modulated material in a random coil fixed polymer matrix and filler.

Abstract: A method of making a microarray comprising the steps of: providing a support; coating on the support a receiving layer to receive microspheres, the receiving layer being capable of undergoing sol/gel transition; coating on the receiving layer a dispersion of microspheres in a carrier fluid, wherein the carrier fluid contains at least one crosslinking agent and is capable of solvating the receiving layer; allowing the microspheres to partially submerge into the receiving layer; creating conditions to induce sol/gel transition in the receiving layer, thus immobilizing the microspheres; evaporating off the carrier fluid; and allowing crosslinking reaction between the receiving layer and the crosslinker in the carrier fluid.

Abstract: The present invention relates to a high contrast reflective display comprising at least one substrate, at least one electrically conductive layer and at least one close-packed, ordered monolayer of domains of electrically modulated material in a fixed, preferably crosslinked, polymer matrix and a method of making the same.

Abstract: The present invention relates to a high contrast reflective display comprising at least one substrate, at least one electrically conductive layer and at least one close-packed, ordered monolayer of domains of electrically modulated material in a fixed, preferably crosslinked, polymer matrix and a method of making the same.

Abstract: The invention relates to a novel class of compounds useful as chiral dopants, which compounds are available in both enantiomeric forms. Another aspect of the invention relates to such compounds having a enantiomeric excess of one enantiomeric form, which are useful in liquid crystal formulations. Such formulations are advantageous in displays and various other products.

Abstract: The present invention relates to a phototunable chiral dopant represented by the following structure: wherein: A, B, C and D are independent divalent groups; X and Z are any independently selected substituent; n is an integer and independently varies from 0 to 3; q is an integer and independently varies from 0 to 5; RNG1 and RNG2 independently represent any ring group; m represents an integer independently varying from 0 to 4; p represents an integer independently varying from 1 to 4; Q independently represents a carbon C—RC, or nitrogen, wherein RC is independently hydrogen or any substituent. The invention also relates to the use of the dopant in a liquid crystalline composition and a display containing the same, as well as a material composition comprising an enantiomeric excess of one enantiomer of the compound.

Abstract: A method of determining one or more color characteristics of a colored microsphere comprising: providing a microarray of microspheres, including at least one colored microsphere which has a color characteristic; producing a magnified optical image of individual microspheres of the microarray; locating a microsphere in the aperture of a spectrometer to confine the color region of interest of the located microsphere in order to determine one or more color characteristics thereof; and determining one or more color characteristics of the located microsphere by means of the spectrometer.

Abstract: A method of making a microarray comprising the steps of:—providing a support;—coating on the support a fluid composition containing microspheres and gelatin;—immobilizing the microspheres in the gelatin coating;—partially digesting the gelatin with an enzyme to expose surfaces of the microspheres; and—removing the enzyme and digested gelatin from the coating.

Abstract: A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of micro-spheres dispersed in a fluid containing a gelling agent or a precursor to a gelling agent and immobilized at random positions on the substrate, at least one sub-population of said population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting said array with a target nucleic acid sequence; and detecting the color barcode of said sub-population of micro-spheres due to the interaction of said probe nucleic acid sequence and said target nucleic acid sequence.

Abstract: The present invention relates to a bistable polymer dispersed liquid crystal display comprising a support, at least one patterned first conductor layer having thereon at least one dried imaging layer comprising a substantial monolayer of isolated domains of liquid crystal material dispersed in a continuous polymer matrix, wherein said dried imaging layer further comprises at least one absorber colorant, and wherein said isolated domains have a size distribution such that the coefficient of variation (cv) is less than 0.35.

Abstract: A display sheet is disclosed comprising, a substrate, first transparent conductors, second conductors and, between first and second conductors, at least one imaging layer comprising a substantial monolayer of isolated domains of liquid-crystal material, dispersed in a continuous matrix, wherein said domains of liquid-crystal material comprises a mixture of at least two populations, a first population comprising a first liquid-crystal material having a first ?max within the infrared spectral region and a second population comprising a second liquid-crystal material having a second ?max within the visible spectral region. Alternately, the imaging layer can comprise a substantial monolayer of isolated domains of liquid-crystal material comprising a population of domains comprising a liquid-crystal material having a ?max between 700 and 800 and having a half-peak width that extends into both the visible spectrum region and the infrared spectral region.

Abstract: A method of determining one or more color characteristics of a colored microsphere comprising: providing a microarray of microspheres, at least one of which has a color characteristic; capturing the microarray with an electronic color image sensor assembly having a matrix of pixels to produce an electronic microarray image; detecting the location of a microsphere within the captured microarray image; and identifying a color characteristic of the detected microsphere.

Abstract: A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of nucleic acid probe modified micro-spheres immobilized in a coating containing a gelling agent or a precursor to a gelling agent, wherein a first portion of the micro-spheres is submerged in the gelatin coating and a second portion is exposed above the gelatin coating and is substantially free of gelatin, at least one sub-population of the population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting the array with a target nucleic acid sequence; and detecting the color barcode of the sub-population of micro-spheres due to the interaction of the probe nucleic acid sequence and the fluorescently/chemiluminescently labeled nucleic acid sample target nucleic acid sequence.

Abstract: A display sheet comprising a substrate carrying layers of material; including a polymer-dispersed chiral-nematic liquid-crystal layer having a first high reflection state within the visible light spectrum and a second less-reflective state in said spectrum, said states being changeable by an electric field, which states can be maintained in the absence of an electric field; a first transparent conductor disposed over said polymer-dispersed chiral-nematic liquid-crystal layer; and a second conductor, wherein said imaging layer is substantially a monolayer of said domains comprises a mixture of at least two differently reflecting liquid crystal materials, in which the ? maximums of the two materials are separated by 100 to 250 nm.

Abstract: A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent, and microspheres; the microspheres containing a dye represented by the Formula (1): wherein: R1=one or more substitutent selected from the group of H, chloro, alkoxycarbonyl, arylsulfamoyl, or alkylsulfamoyl; R2=one or more substituent selected from the group of H, carboxamido, or alkoxycarbonyl; R3=one or more substituent selected from the group of H, chloro, substituted or unsubstituted alkyl, aryl, carboxamido, or alkoxycarbonyl.

Abstract: A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent and microspheres; the microspheres containing a dye represented by Formula (I): wherein: R1 is one or more substituents selected from the group consisting of H, Cl, Br, I, substituted or unsubstituted alkyl, alkylamino, arylamino, acyl, nitrile, alkoxy, aryl, heteroaryl, sulfone, sulfamoyl, sulfonamido, or substituted or unsubstituted amido; and R2 and R3 are independently H, substituted amino, alkoxy, substituted or unsubstituted alkyl, substituted amido, or Cl.