Patents by Inventor Kristine E. Frank

Kristine E. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazo based heterocycles
    Patent number: 7709468
    Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: May 4, 2010
    Assignee: Abbott Laboratories
    Inventors: David J. Calderwood, Kristine E. Frank, Patrick Betschmann, Gavin C. Hirst, Eric C. Brieinlinger, Michael J. Morytko, Richard W. Dixon
  • Novel Tricyclic Compounds
    Publication number: 20090312338
    Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 17, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Neil Wishart, Maria A. Argiriadi, David J. Calderwood, Anna M. Ericsson, Bryan A. Fiamengo, Kristine E. Frank, Michael Friedman, Dawn M. George, Eric R. Goedken, Nathan S. Josephsohn, Biqin C. Li, Michael J. Morytko, Kent D. Stewart, Jeffrey W. Voss, Grier A. Wallace, Lu Wang, Kevin R. Woller
  • Novel triazolopyridazines
    Publication number: 20090270402
    Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Application
    Filed: June 26, 2008
    Publication date: October 29, 2009
    Inventors: David J. Calderwood, Dominique F. Bonafoux, Andrew Burchat, Ping Ding, Kristine E. Frank, Michael Z. Hoemann, Kelly D. Mullen, Heather M. Davis
  • Novel imidazole based heterocycles
    Publication number: 20080249305
    Abstract: The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 9, 2008
    Inventors: David J. Calderwood, Kristine E. Frank, Patrick Betschmann, Eric C. Breinlinger, Richard W. Dixon
  • Novel imidazo based heterocycles
    Publication number: 20080242862
    Abstract: The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Application
    Filed: March 27, 2007
    Publication date: October 2, 2008
    Inventors: David J. Calderwood, Kristine E. Frank, Patrick Betschmann, Eric C. Breinlinger, Richard W. Dixon
  • Novel imidazothiazoles and imidazoxazoles
    Publication number: 20080161341
    Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Application
    Filed: October 5, 2007
    Publication date: July 3, 2008
    Inventors: David J. Calderwood, Kristine E. Frank, David W. Borhani, Heather M. Davis, Nathan S. Josephsohn, Barbara S. Skinner
  • Compounds as CRFreceptor antagonists
    Patent number: 7250418
    Abstract: The present invention relates to compounds of Formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF1 receptor antagonists. Compounds of the invention are useful for treating, in a warm-blooded animal, particularly a mammal, and more particularly a human, various disorders that are associated with CRF or CRF1 receptors, or disorders the treatment of which can be effected or facilitated by antagonizing CRF1 receptors.
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: July 31, 2007
    Assignee: Pfizer Inc
    Inventors: Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted pyrimidine derivatives
    Patent number: 7087617
    Abstract: This invention relates to compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds interact with CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety-related disorders such as anxiety, and mood disorders such as major depression.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: August 8, 2006
    Assignee: Pfizer Inc.
    Inventors: Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted aryl 1, 4-pyrazine derivatives
    Patent number: 7041672
    Abstract: Substituted aryl pyrazine derivatives of the formula I as defined herein, and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: May 9, 2006
    Assignee: Pfizer Inc.
    Inventors: Patrick R. Verhoest, Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu, Robert Louis Hoffman
  • Substituted pyrimidinones and pyrimidinthiones
    Patent number: 7015229
    Abstract: This invention relates to substituted pyrimidinone and pyrimidithione derivatives that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: March 21, 2006
    Assignee: Pfizer Inc
    Inventors: Jian-Min Fu, Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted aryl 1,4-pyrazine derivatives
    Patent number: 6992087
    Abstract: Substituted aryl 1,4-pyrazine derivatives of formula I as defined herein and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: January 31, 2006
    Assignee: Pfizer Inc
    Inventors: Patrick R. Verhoest, Robert Louis Hoffman, Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu
  • Substituted pyrazine derivatives
    Patent number: 6964965
    Abstract: The present invention provides substituted pyrazine derivatives of Formula I, that are CRF1 receptor antagonists, including human CRF1 receptors. This invention also relates to use of compounds of the invention for treating a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders, particularly anxiety-related disorders and mood disorders.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: November 15, 2005
    Assignee: Pharmacia & Upjohn
    Inventors: Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted azepino[4,5b]indole derivatives
    Patent number: 6903090
    Abstract: Disclosed are compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: June 7, 2005
    Assignee: Pfizer
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
  • Tetracyclic azepinoindole compounds
    Patent number: 6875762
    Abstract: The present invention provides compounds of formula I: wherein R1, R2, X and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of formula (I).
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: April 5, 2005
    Assignee: Pfizer
    Inventors: Jackson B. Hester, Bruce N. Rogers, Eric Jon Jacobsen, Michael D. Ennis, Brad A. Acker, Susan L. Vander Velde, Kristine E. Frank
  • Therapeutic 1H-pyrido [4,3-b] indoles
    Patent number: 6849640
    Abstract: The present invention provides 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles and 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. These compounds are 5-HT ligands that are useful for treating diseases wherein modulation of 5-HT activity is desired.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: February 1, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael D. Ennis, Kristine E. Frank, Robert L. Hoffman, Jian-Min Fu
  • Substituted azepino[4,5b]indoline derivatives
    Patent number: 6828314
    Abstract: The invention provides compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: December 7, 2004
    Assignee: Pfizer
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, Eric Jon Jacobsen, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier
  • Tetracyclic azepinoindole compounds
    Publication number: 20040138202
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Applicant: Pharmacia and Upjohn Company
    Inventors: Jackson B. Hester, Bruce N. Rogers, Eric Jon Jacobsen, Michael D. Ennis, Brad A. Acker, Susan L. Vander Velde, Kristine E. Frank
  • Substituted 1,4-pyrazine derivatives
    Publication number: 20040116444
    Abstract: Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
    Type: Application
    Filed: August 27, 2003
    Publication date: June 17, 2004
    Inventors: Jeffrey W. Corbett, Jian-Min Fu, Michael Dalton Ennis, Kristine E. Frank, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted pyrazine derivatives
    Publication number: 20040053941
    Abstract: The present invention provides substituted pyrazine derivatives of Formula I, 1
    Type: Application
    Filed: April 17, 2003
    Publication date: March 18, 2004
    Inventors: Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted azepino[4,5b]indoline derivatives
    Publication number: 20030225058
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: March 20, 2003
    Publication date: December 4, 2003
    Applicant: Pharmacia & UpJohn Company
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-Min Fu, Eric Jon Jacobsen, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier