Patents by Inventor Kristine E. Frank

Kristine E. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted azepino[4,5b]indole derivatives
    Publication number: 20030220321
    Abstract: Disclosed are compounds of Formula (I): 1
    Type: Application
    Filed: March 20, 2003
    Publication date: November 27, 2003
    Applicant: Pharmacia & UpJohn Company
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-Min Fu, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
  • Substituted pyrimidinones and pyrimidinthiones
    Publication number: 20030195222
    Abstract: This invention relates to substituted pyrimidinone and pyrimidithione derivatives that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.
    Type: Application
    Filed: February 20, 2003
    Publication date: October 16, 2003
    Inventors: Jian-Min Fu, Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Robert Louis Hoffman, Patrick R. Verhoest
  • Substituted aryl 1,4-pyrazine derivatives
    Publication number: 20030144297
    Abstract: Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
    Type: Application
    Filed: November 15, 2002
    Publication date: July 31, 2003
    Inventors: Patrick R. Verhoest, Robert Louis Hoffman, Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu
  • Substituted azepino[4,5b]indoline derivatives
    Patent number: 6586421
    Abstract: The invention provides compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: July 1, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, Eric Jon Jacobsen, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier
  • Substituted azepino[4,5b]indole derivatives
    Patent number: 6583135
    Abstract: Disclosed are compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: June 24, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
  • Therapeutic 1H-pyrido [ 4, 3-b ] indoles
    Publication number: 20030060464
    Abstract: The present invention provides 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles and 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. These compounds are 5-HT ligands that are useful for treating diseases wherein modulation of 5-HT activity is desired.
    Type: Application
    Filed: August 6, 2002
    Publication date: March 27, 2003
    Inventors: Michael D. Ennis, Kristine E. Frank, Robert L. Hoffman, Jian-Min Fu
  • Tetracyclic azepinoindole compounds
    Publication number: 20020198190
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: June 17, 2002
    Publication date: December 26, 2002
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Jackson B. Hester, Bruce N. Rogers, Eric Jon Jacobsen, Michael D. Ennis, Brad A. Acker, Susan L. Vander Velde, Kristine E. Frank
  • Substituted azepino[4,5b]indole derivatives
    Publication number: 20020107278
    Abstract: Disclosed are compounds of Formula (I): 1
    Type: Application
    Filed: September 20, 2001
    Publication date: August 8, 2002
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
  • Substituted azepino[4,5b] indoline derivatives
    Publication number: 20020077318
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: September 20, 2001
    Publication date: June 20, 2002
    Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, Eric Jon Jacobsen, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier
  • Tetracyclic azepinoindole compounds
    Patent number: 6407092
    Abstract: The present invention provides compounds of formula I: wherein R1, R2, X and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of formula (I).
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: June 18, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jackson B. Hester, Bruce N. Rogers, Eric Jon Jacobsen, Michael D. Ennis, Brad A. Acker, Susan L. Vander Velde, Kristine E. Frank