Patents by Inventor Krzysztof Matyjaszewski

Krzysztof Matyjaszewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200308568
    Abstract: The present disclosure provides enzyme-polymer conjugates stable to denaturing action of alcohols and methods for using enzyme-polymer conjugates in biocatalysis.
    Type: Application
    Filed: March 24, 2020
    Publication date: October 1, 2020
    Inventors: Antonina Simakova, Gregory Lewis, Alan Russell, Krzysztof Matyjaszewski
  • Publication number: 20200093930
    Abstract: Provided herein are methods and systems for concurrently synthesizing and screening a plurality of biomolecule-initiator conjugates and biomolecule-polymer conjugates. Also disclosed are methods of removing oxygen from reaction mixtures and methods of purifying the biomolecule conjugates.
    Type: Application
    Filed: June 7, 2018
    Publication date: March 26, 2020
    Inventors: Antonina SIMAKOVA, Alan RUSSELL, Krzysztof MATYJASZEWSKI
  • Publication number: 20200071168
    Abstract: A method for preparation of mesoporous nitrogen-doped carbon includes forming a composition by solubilizing a nitrogen-containing polymer in an aqueous solution of ZnCl2 and drying the aqueous solution, the method further includes heating the composition after drying to a temperature sufficiently high to carbonize the nitrogen-containing polymer to form the mesoporous nitrogen-doped carbon.
    Type: Application
    Filed: September 3, 2019
    Publication date: March 5, 2020
    Inventors: Krzysztof Matyjaszewski, Jianan Zhang, Michael R. Bockstaller
  • Publication number: 20200055967
    Abstract: Systems and methods for Atom Transfer Radical Polymerization (ATRP) emulsion polymerization are provided. The ATRP emulsion polymerization comprises a suspending medium, a dispersed medium, a surfactant, a transition metal compound in a higher oxidation state, a ligand, and an ATRP initiator. The transition metal compound is capable of forming a catalyst complex in a presence of the ligand. The catalyst complex is soluble in the suspending medium and is capable of forming an ionic complex with the surfactant. The ionic complex is capable of moving between the suspending medium and the dispersed medium. A portion of the transition metal compound in the higher oxidation state within a portion of the catalyst complex is reduced by a physical and/or a chemical procedure thereby initiating a polymerization of one or more radically (co)polymerizable monomers by reaction with the initiator.
    Type: Application
    Filed: January 11, 2018
    Publication date: February 20, 2020
    Inventors: Marco FANTIN, Pawel CHMIELARZ, Yi WANG, Francesca LORANDI, Krzysztof MATYJASZEWSKI
  • Publication number: 20200024372
    Abstract: Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.
    Type: Application
    Filed: July 23, 2019
    Publication date: January 23, 2020
    Inventors: Krzysztof Matyjaszewski, Alan Enciso Barros, Liye Fu, Alan J. Russell
  • Publication number: 20190099521
    Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
    Type: Application
    Filed: April 13, 2017
    Publication date: April 4, 2019
    Inventors: Xavier Banquy, Jimmy Faivre, Buddha Ratna Shrestha, Krzysztof Matyjaszewski, Joanna Burdynska, Florina Moldovan
  • Publication number: 20190031810
    Abstract: A composition formed by dispersing at least a plurality of first particles within a matrix material and dispersing at least a plurality of second particles within the matrix material, the second particles being different from the first particles, wherein interaction between the at least a plurality of second particles and the at least a plurality of first particles determines a spatial distribution of the plurality of second particles within the matrix material.
    Type: Application
    Filed: January 24, 2017
    Publication date: January 31, 2019
    Inventors: Michael R. Bockstaller, Amir Khabibullin, Zongyu Wang, Hangjun Ding, Guojun Xie, Krzysztof Matyjaszewski, Jiajun Yan, Zhao Lu
  • Publication number: 20180325820
    Abstract: A biocompatible, water-soluble polymer includes segments formed via an atom transfer radical polymerization and including sulfoxide functionality. The segments including sulfoxide functionality have a dispersity less than or equal to 1.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 15, 2018
    Inventors: Krzysztof Matyjaszewski, Sipei Li
  • Patent number: 10072042
    Abstract: Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: September 11, 2018
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Krzysztof Matyjaszewski, Saadyah E. Averick, Antonina Simakova
  • Patent number: 9982070
    Abstract: A process for polymerizing radically (co)polymerizable monomers at a temperature between ?10° C. and 110° C. in an aqueous system comprising one or more radically (co)polymerizable monomer(s) is disclosed, and includes a molar excess of a ligand forming a soluble transition metal complex with an added transition metal salt that participates in a reversible reduction-oxidation cycle with one of an added site specific functional initiator and a dormant polymer chain having a radically transferable atom or group. The initial soluble catalyst complex concentration in the higher oxidation state is less than or equal to 2500 ppm. The reaction is conducted in the presence of an activator regenerator. The mole fraction of the soluble lower activator oxidation state transition metal formed by action of the activator regenerator, to transition metal in a higher deactivator oxidation state is less than 10%. The formed polymer chains have a dispersity of less than 1.5.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: May 29, 2018
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Krzysztof Matyjaszewski, Pawel Chmielarz, Dominik Konkolewicz, Pawel Krys, Xiangcheng Pan, Valerie Williams
  • Publication number: 20180142288
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 24, 2018
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • Patent number: 9969823
    Abstract: Herein, we describe polymerized ionic liquids, demonstrate the synthesis of polymerized ionic liquids, and demonstrate the polymerization of triazolium monomers. One embodiment shows the polymeriazation of the triazolium monomers with bis(trifluoromethanesulfonyl)imide anions. In another embodiment we show the feasibility of copolymerizing with commodity monomers such as styrene using free radical polymerization techniques.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: May 15, 2018
    Assignee: The United States of America as represented by the Department of Energy
    Inventors: David Luebke, Hunaid Nulwala, Krzysztof Matyjaszewski, Brian Adzima
  • Patent number: 9790305
    Abstract: The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 17, 2017
    Assignee: Franklin and Marshall College
    Inventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
  • Patent number: 9765169
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: September 19, 2017
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Subha Ranjan Das, Saadyah Averick, Sourav K. Dey, Krzysztof Matyjaszewski
  • Publication number: 20170158836
    Abstract: A three-dimensionally ordered macroporous hydrogel for immobilizing a selected bioresponsive molecule and method of making are disclosed. The three-dimensionally ordered macroporous hydrogel comprises a crosslinked polymer that has a system of interconnected pores. The interconnected pores have a uniform pore size in the range of 50 to 5000 nm, and a plurality of first pore functional groups. The plurality of first pore functional groups is selected to immobilize a selected bioresponsive molecule. Examples of bioresponsive molecules include an enzyme; a molecule for: a protein scaffold, solid phase synthesis, nucleic acid synthesis, polypeptide synthesis, analyte detection, adsorption of analytes and measuring analyte concentrations, organic synthesis, and degradation of biologically active agents in wastewater. A method includes forming a colloidal crystal template, polymerizing a hydrogel within the pores of the colloidal crystal template, and selectively removing the colloidal crystal template.
    Type: Application
    Filed: November 25, 2014
    Publication date: June 8, 2017
    Inventors: Krzysztof Matyjaszewski, Saadyah Averick, Hongkun He
  • Publication number: 20170152336
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Application
    Filed: April 17, 2014
    Publication date: June 1, 2017
    Inventors: SUBHA RANJAN DAS, SAADYAH AVERICK, SOURAV K. DEY, Krzysztof Matyjaszewski
  • Publication number: 20170145048
    Abstract: Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.
    Type: Application
    Filed: December 14, 2016
    Publication date: May 25, 2017
    Inventors: Krzysztof Matyjaszewski, Saadyah E. Averick, Antonina Simakova
  • Patent number: 9644042
    Abstract: Electrochemical reduction of an exemplary ATRP catalyst, CIIBr2/Me6TREN, is shown to be an efficient process to mediate and execute an ATRP. The onset of polymerization occurs only through passage of a cathodic current achieved under a reductive potential to form CuIBr2/Me6TREN, within the reaction medium. Unprecedented control over the polymerization kinetics can be attained through electrochemical methods by modulating the magnitude of the applied potential allowing polymerization rate enhancement or retardation. Additional polymerization control is gained through electrochemical “dials” allowing polymerization rate enhancements achieved by larger applied potentials and the ability to successfully switch a polymerization “on” and “off between dormant and active states by application of multistep intermittent potentials.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: May 9, 2017
    Assignee: Carnegie Mellon University
    Inventors: Krzysztof Matyjaszewski, Nicola Bortolamei, Andrew Magenau, Armando Gennaro, Abdirisak Ahmed Isse
  • Publication number: 20170113934
    Abstract: Carbon-based nanomaterials comprising graphitic domains that are doped with heteroatoms are disclosed. Processes for the production the nanomaterials, methods of using the nanomaterials, and articles or devices comprising the nanomaterials are also disclosed.
    Type: Application
    Filed: June 24, 2016
    Publication date: April 27, 2017
    Inventors: Tomasz Kowalewski, Mingjiang Zhong, Eric Gottlieb, Maciej Kopec, Jacob Mohin, Krzysztof Matyjaszewski
  • Patent number: 9533297
    Abstract: A series of ligands with site specific electron donating substituents that form a catalyst complex with a transition metal and are suitable for catalysis of atom transfer radical reactions, including ATRP are described. Faster catalysis rates were observed allowing for low catalyst concentrations and linear increases in molecular weight with monomer conversion, and narrow molecular weight distributions. Cyclic voltammetry revealed that increasing the strength and number of conjugated electron donating groups resulted in more stable complexes and larger ATRP equilibrium constants.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: January 3, 2017
    Assignee: Carnegie Mellon University
    Inventors: Krzysztof Matyjaszewski, Yungwan Kwak, Joanna Burdynska, Andrea Elsen, Kristin Schroeder