Patents by Inventor Krzysztof Matyjaszewski

Krzysztof Matyjaszewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220145291
    Abstract: Provided herein are tethered extracellular vesicles and methods of making tethered extracellular vesicles.
    Type: Application
    Filed: February 14, 2020
    Publication date: May 12, 2022
    Inventors: Subha Ranjan Das, Phil G. Campbell, Krzysztof Matyjaszewski, Sushil Lathwal, Saigopalakrishna Saileelaprasad Yernei
  • Publication number: 20220077460
    Abstract: A process for the formation of a deformable battery electrode includes mixing a metal component including at least one of a metal or a metal alloy, a polymer component, and a dispersant component to create a mixture. The method further includes heated the mixture to a temperature above the melting point of the metal or the metal alloy and agitating the mixture to form a dispersion of the (molten) metal or the metal alloy in the mixture. The method further includes cooling the mixture to a temperature below the melting point of the metal or the metal alloy to form a stabilized dispersion of the metal or the metal alloy. The polymer component includes a polymer having a melting point equal to or below that of the metal or the metal alloy and a glass transition temperature sufficiently low that the stabilized dispersion is deformable.
    Type: Application
    Filed: December 17, 2019
    Publication date: March 10, 2022
    Inventors: Krzysztof Matyjaszewski, Jay F. Whitacre, Sipei Li, Francesca Lorandi
  • Patent number: 11174325
    Abstract: Systems and methods for Atom Transfer Radical Polymerization (ATRP) emulsion polymerization are provided. The ATRP emulsion polymerization comprises a suspending medium, a dispersed medium, a surfactant, a transition metal compound in a higher oxidation state, a ligand, and an ATRP initiator. The transition metal compound is capable of forming a catalyst complex in a presence of the ligand. The catalyst complex is soluble in the suspending medium and is capable of forming an ionic complex with the surfactant. The ionic complex is capable of moving between the suspending medium and the dispersed medium. A portion of the transition metal compound in the higher oxidation state within a portion of the catalyst complex is reduced by a physical and/or a chemical procedure thereby initiating a polymerization of one or more radically (co)polymerizable monomers by reaction with the initiator.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: November 16, 2021
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Marco Fantin, Pawel Chmielarz, Yi Wang, Francesca Lorandi, Krzysztof Matyjaszewski
  • Publication number: 20210309783
    Abstract: A method of carrying out an atom transfer radical polymerization wherein intermolecular crosslinking can occur includes controlling an amount of crosslinking by carrying out the reaction under conditions wherein catalytic radical termination is favored over radical termination.
    Type: Application
    Filed: June 1, 2019
    Publication date: October 7, 2021
    Inventors: Krzysztof MATYJASZEWSKI, Guojun XIE, Michael R. MARTINEZ, Thomas G. RIBELLI
  • Publication number: 20210290769
    Abstract: Materials and methods for targeted and controlled addition of polymers to proteins are provided herein. For example, the methods provided herein can include contacting a protein with (i) an inactive controlled radical polymerization (CRP) initiator blocker that can reacts with amino groups on the protein but cannot serve as an initiator for polymer addition, and (ii) an active CRP initiator that reacts with amino groups on the protein and also includes a group through which a polymer can be coupled to the initiator.
    Type: Application
    Filed: August 1, 2019
    Publication date: September 23, 2021
    Inventors: Alan J. Russell, Hironobu Murata, Sheiliza Carmali, Krzysztof Matyjaszewski
  • Publication number: 20210187166
    Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
    Type: Application
    Filed: March 1, 2021
    Publication date: June 24, 2021
    Inventors: Xavier Banquy, Jimmy Faivre, Buddha Ratna Shrestha, Krzysztof Matyjaszewski, Joanna Burdynska, Florina Moldovan
  • Patent number: 10982266
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 20, 2021
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • Patent number: 10934383
    Abstract: A composition formed by dispersing at least a plurality of first particles within a matrix material and dispersing at least a plurality of second particles within the matrix material, the second particles being different from the first particles, wherein interaction between the at least a plurality of second particles and the at least a plurality of first particles determines a spatial distribution of the plurality of second particles within the matrix material.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: March 2, 2021
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Michael R. Bockstaller, Amir Khabibullin, Zongyu Wang, Hangjun Ding, Guojun Xie, Krzysztof Matyjaszewski, Jiajun Yan, Zhao Lu
  • Patent number: 10933166
    Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: March 2, 2021
    Assignees: VALORISATION-RECHERCHE, LIMITED PARTNERSHIP, CARNEGIE MELLON UNIVERSITY, VALORISATION HSJ, LIMITED PARTNERSHIP
    Inventors: Xavier Banquy, Jimmy Faivre, Buddha Ratna Shrestha, Krzysztof Matyjaszewski, Joanna Burdynska, Florina Moldovan
  • Publication number: 20200308568
    Abstract: The present disclosure provides enzyme-polymer conjugates stable to denaturing action of alcohols and methods for using enzyme-polymer conjugates in biocatalysis.
    Type: Application
    Filed: March 24, 2020
    Publication date: October 1, 2020
    Inventors: Antonina Simakova, Gregory Lewis, Alan Russell, Krzysztof Matyjaszewski
  • Publication number: 20200093930
    Abstract: Provided herein are methods and systems for concurrently synthesizing and screening a plurality of biomolecule-initiator conjugates and biomolecule-polymer conjugates. Also disclosed are methods of removing oxygen from reaction mixtures and methods of purifying the biomolecule conjugates.
    Type: Application
    Filed: June 7, 2018
    Publication date: March 26, 2020
    Inventors: Antonina SIMAKOVA, Alan RUSSELL, Krzysztof MATYJASZEWSKI
  • Publication number: 20200071168
    Abstract: A method for preparation of mesoporous nitrogen-doped carbon includes forming a composition by solubilizing a nitrogen-containing polymer in an aqueous solution of ZnCl2 and drying the aqueous solution, the method further includes heating the composition after drying to a temperature sufficiently high to carbonize the nitrogen-containing polymer to form the mesoporous nitrogen-doped carbon.
    Type: Application
    Filed: September 3, 2019
    Publication date: March 5, 2020
    Inventors: Krzysztof Matyjaszewski, Jianan Zhang, Michael R. Bockstaller
  • Publication number: 20200055967
    Abstract: Systems and methods for Atom Transfer Radical Polymerization (ATRP) emulsion polymerization are provided. The ATRP emulsion polymerization comprises a suspending medium, a dispersed medium, a surfactant, a transition metal compound in a higher oxidation state, a ligand, and an ATRP initiator. The transition metal compound is capable of forming a catalyst complex in a presence of the ligand. The catalyst complex is soluble in the suspending medium and is capable of forming an ionic complex with the surfactant. The ionic complex is capable of moving between the suspending medium and the dispersed medium. A portion of the transition metal compound in the higher oxidation state within a portion of the catalyst complex is reduced by a physical and/or a chemical procedure thereby initiating a polymerization of one or more radically (co)polymerizable monomers by reaction with the initiator.
    Type: Application
    Filed: January 11, 2018
    Publication date: February 20, 2020
    Inventors: Marco FANTIN, Pawel CHMIELARZ, Yi WANG, Francesca LORANDI, Krzysztof MATYJASZEWSKI
  • Publication number: 20200024372
    Abstract: Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.
    Type: Application
    Filed: July 23, 2019
    Publication date: January 23, 2020
    Inventors: Krzysztof Matyjaszewski, Alan Enciso Barros, Liye Fu, Alan J. Russell
  • Publication number: 20190099521
    Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
    Type: Application
    Filed: April 13, 2017
    Publication date: April 4, 2019
    Inventors: Xavier Banquy, Jimmy Faivre, Buddha Ratna Shrestha, Krzysztof Matyjaszewski, Joanna Burdynska, Florina Moldovan
  • Publication number: 20190031810
    Abstract: A composition formed by dispersing at least a plurality of first particles within a matrix material and dispersing at least a plurality of second particles within the matrix material, the second particles being different from the first particles, wherein interaction between the at least a plurality of second particles and the at least a plurality of first particles determines a spatial distribution of the plurality of second particles within the matrix material.
    Type: Application
    Filed: January 24, 2017
    Publication date: January 31, 2019
    Inventors: Michael R. Bockstaller, Amir Khabibullin, Zongyu Wang, Hangjun Ding, Guojun Xie, Krzysztof Matyjaszewski, Jiajun Yan, Zhao Lu
  • Publication number: 20180325820
    Abstract: A biocompatible, water-soluble polymer includes segments formed via an atom transfer radical polymerization and including sulfoxide functionality. The segments including sulfoxide functionality have a dispersity less than or equal to 1.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 15, 2018
    Inventors: Krzysztof Matyjaszewski, Sipei Li
  • Patent number: 10072042
    Abstract: Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: September 11, 2018
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Krzysztof Matyjaszewski, Saadyah E. Averick, Antonina Simakova
  • Patent number: 9982070
    Abstract: A process for polymerizing radically (co)polymerizable monomers at a temperature between ?10° C. and 110° C. in an aqueous system comprising one or more radically (co)polymerizable monomer(s) is disclosed, and includes a molar excess of a ligand forming a soluble transition metal complex with an added transition metal salt that participates in a reversible reduction-oxidation cycle with one of an added site specific functional initiator and a dormant polymer chain having a radically transferable atom or group. The initial soluble catalyst complex concentration in the higher oxidation state is less than or equal to 2500 ppm. The reaction is conducted in the presence of an activator regenerator. The mole fraction of the soluble lower activator oxidation state transition metal formed by action of the activator regenerator, to transition metal in a higher deactivator oxidation state is less than 10%. The formed polymer chains have a dispersity of less than 1.5.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: May 29, 2018
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Krzysztof Matyjaszewski, Pawel Chmielarz, Dominik Konkolewicz, Pawel Krys, Xiangcheng Pan, Valerie Williams
  • Publication number: 20180142288
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 24, 2018
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick