Patents by Inventor Kui Gao

Kui Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240360435
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: July 12, 2024
    Publication date: October 31, 2024
    Applicant: Gen-Probe Incorporated
    Inventors: Kui GAO, Jijumon CHELLISERRY, Jeffrey LINNEN
  • Patent number: 12071615
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: August 27, 2024
    Assignee: Gen-Probe Incorporated
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Publication number: 20240011109
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: August 29, 2023
    Publication date: January 11, 2024
    Inventors: Kui GAO, Jeffrey M. LINNEN
  • Publication number: 20230393040
    Abstract: The present disclosure includes, but is not limited to, methods and systems for pooling or combining multiple samples together. Particularly, this disclosure relates to pooling and combining samples in a process and system that combines samples in a way that allows targets in the pooled sample to be analyzed/detected with a similar sensitivity and specificity as for analysis/detection of targets from the individual samples of the pool. Specifically, in some embodiments, methods herein avoid a dilution effect found in commonly used sample pooling methods that can reduce their sensitivity and limit the number of samples that can be pooled. In some embodiments, methods herein include processes to de-convolute the pool down to individual samples. Methods herein may be applicable to creating and testing pooled/combined samples for target molecules and de-convoluting pooled samples to identify an individual sample in a pool containing the target.
    Type: Application
    Filed: October 21, 2021
    Publication date: December 7, 2023
    Inventor: Kui Gao
  • Patent number: 11821046
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: November 21, 2023
    Assignee: Gen-Probe Incorporated
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Publication number: 20230357872
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: July 19, 2023
    Publication date: November 9, 2023
    Inventors: Kui GAO, Edgar O. ONG, Jennifer COLE, Jeffrey M. Linnen
  • Publication number: 20230220499
    Abstract: The medical field of COVID-19 diagnosis relates to methods for detecting SARS-CoV-2 nucleic acids in a sample as well as combinations of oligomers for determining the presence or absence of SARS-CoV-2 in a Sample.
    Type: Application
    Filed: May 7, 2021
    Publication date: July 13, 2023
    Inventors: Kui GAO, Anthony JAMES, Vanessa BRES
  • Patent number: 11572596
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 7, 2023
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • Patent number: 11332798
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: May 17, 2022
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Publication number: 20220145408
    Abstract: Nucleic acid oligomers specific for human parvovirus genomic DNA. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human biological specimens.
    Type: Application
    Filed: January 20, 2022
    Publication date: May 12, 2022
    Inventors: Kui GAO, Jeffrey M. LINNEN, Kurt C. NORTON, Patricia C. GORDON, Dat DO, Tan N. LE
  • Publication number: 20220074003
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 10, 2022
    Applicant: Gen-Probe Incorporated
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Patent number: 11268159
    Abstract: Nucleic acid oligomers specific for human parvovirus genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens is disclosed. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human biological specimens are disclosed.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: March 8, 2022
    Assignee: Gen-Probe Incorporated
    Inventors: Kui Gao, Jeffrey M. Linnen, Kurt C. Norton, Patricia C. Gordon, Dat Do, Tan N. Le
  • Patent number: 11242571
    Abstract: Various aspects of the invention relate to compositions and methods of analyzing blood plasma, blood serum, and manufacturing pools of plasma-derived products wherein an anionic surfactant is added to an aliquot of the blood plasma, blood serum, or manufacturing pool prior to analysis, and the counterion of the anionic surfactant is not sodium ion. The anionic surfactant may be, for example, lauryl sulfate. The counterion of the anionic surfactant may be, for example, lithium ion.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: February 8, 2022
    Assignee: GRIFOLS DIAGNOSTIC SOLUTIONS INC.
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Patent number: 11220719
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: January 11, 2022
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Publication number: 20220002707
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: September 27, 2021
    Publication date: January 6, 2022
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Publication number: 20210404019
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: September 15, 2021
    Publication date: December 30, 2021
    Inventors: Jijumon CHELLISERRY, Kui GAO, Jeffrey M. LINNEN
  • Publication number: 20210355553
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: July 21, 2021
    Publication date: November 18, 2021
    Inventors: Kui GAO, Edgar O. ONG, Jennifer COLE, Jeffrey M. Linnen
  • Patent number: 11162091
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 2, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Patent number: 11162145
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: November 2, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Patent number: D1040623
    Type: Grant
    Filed: March 22, 2024
    Date of Patent: September 3, 2024
    Inventor: Kui Gao