Patents by Inventor Kui Gao

Kui Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for isolating a target nucleic acid from red blood cells
    Patent number: 11162145
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: November 2, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Blood cell lysis reagent
    Patent number: 11015185
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: May 25, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • BLOOD CELL LYSIS REAGENT
    Publication number: 20210139886
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: December 28, 2020
    Publication date: May 13, 2021
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • A METHOD TO HOMOGENIZE PARVOVIRUS B19 IN CLINICAL SAMPLES
    Publication number: 20210115523
    Abstract: Various aspects of the invention relate to compositions and methods of analyzing blood plasma, blood serum, and manufacturing pools of plasma-derived products wherein an anionic surfactant is added to an aliquot of the blood plasma, blood serum, or manufacturing pool prior to analysis, and the counterion of the anionic surfactant is not sodium ion. The anionic surfactant may be, for example, lauryl sulfate. The counterion of the anionic surfactant may be, for example, lithium ion.
    Type: Application
    Filed: January 25, 2019
    Publication date: April 22, 2021
    Applicant: Grifols Diagnostic Solutions Inc.
    Inventors: Kui Gao, Jeffrey M. Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID
    Publication number: 20210010093
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 14, 2021
    Inventors: Kui GAO, Jeffrey M. LINNEN
  • COMPOSITIONS AND METHODS FOR DETECTING HEV NUCLEIC ACID
    Publication number: 20200399720
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: Kui GAO, Edgar O. ONG, Jennifer COLE, Jeffrey M. Linnen
  • Compositions and methods for detecting HEV nucleic acid
    Patent number: 10815541
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 27, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • METHODS FOR ISOLATING A TARGET NUCLEIC ACID FROM RED BLOOD CELLS
    Publication number: 20200308661
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: May 8, 2020
    Publication date: October 1, 2020
    Inventors: Jijumon CHELLISERRY, Kui GAO, Jeffrey M. LINNEN
  • Red blood cell lysis solution
    Patent number: 10689713
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: June 23, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Compositions and Methods for Detecting or Quantifying Hepatitis B Virus
    Publication number: 20200063218
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Applicant: Gen-Probe Incorporated
    Inventors: Kui Gao, Jeffrey M. Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID
    Publication number: 20200040411
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 6, 2020
    Inventors: Kui GAO, Jeffrey M. LINNEN
  • Compositions and methods for detecting or quantifying Hepatitis B virus
    Patent number: 10508313
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 17, 2019
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Compositions and methods for detecting Zika virus nucleic acid
    Patent number: 10508312
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 17, 2019
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jeffrey M. Linnen
  • BLOOD CELL LYSIS REAGENT
    Publication number: 20190136225
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: April 26, 2017
    Publication date: May 9, 2019
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING HEV NUCLEIC ACID
    Publication number: 20180334734
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: June 22, 2018
    Publication date: November 22, 2018
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • RED BLOOD CELL LYSIS SOLUTION
    Publication number: 20180334727
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: June 27, 2018
    Publication date: November 22, 2018
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Red blood cell lysis solution
    Patent number: 10093989
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: October 9, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Compositions and methods for detecting HEV nucleic acid
    Patent number: 10053742
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: August 21, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • Compositions and methods for detecting HEV nucleic acid
    Patent number: 10047406
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: August 14, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS B VIRUS
    Publication number: 20180155800
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Application
    Filed: November 17, 2017
    Publication date: June 7, 2018
    Inventors: Kui GAO, Jeffrey M. LINNEN