Abstract: Provided herein are combination therapies comprising GDC-9545 and ipatasertib for treating locally advanced breast cancer or metastatic breast cancer.

Abstract: Provided herein are combination therapies comprising an ATP competitive AKT inhibitor, fulvestrant, and CDK4/6 inhibitor for use in treating hormone receptor positive and HER2 negative locally advanced unresectable or metastatic breast cancer.

Abstract: Provided herein are combination therapies comprising an ATP competitive AKT inhibitor, fulvestrant, and CDK4/6 inhibitor for use in treating hormone receptor positive and HER2 negative locally advanced unresectable or metastatic breast cancer.

Abstract: A media management system including an application layer, a system layer, and a solid state drive (SSD) storage layer. The application layer includes a media data analytics application configured to assign a classification code to a data file. The system layer is in communication with the application layer. The system layer includes a file system configured to issue a write command to a SSD controller. The write command includes the classification code of the data file. The SSD storage layer includes the SSD controller and erasable blocks. The SSD controller is configured to write the data file to one of the erasable blocks based on the classification code of the data file in the write command. In an embodiment, the SSD controller is configured to write the data file to one of the erasable blocks storing other data files also having the classification code.

Abstract: Provided herein are combination therapies comprising an ATP competitive AKT inhibitor, fulvestrant, and CDK4/6 inhibitor for use in treating hormone receptor positive and HER2 negative locally advanced unresectable or metastatic breast cancer.

Abstract: Disclosed is a method for quantifying the taste of wine, comprising the following steps: S1: selecting a sample of the wine; S2: selecting the alcoholic strength, total acidity, total sugar, glycerol, dimethyl butanol, esters and resveratrol as the quantitative indexes of the taste of the wine; S3: detecting the quantitative indexes selected in S2; S4: standardizing the detection results obtained in S3 by using a Max?Min standardized method, and classifying and assigning values to the standardized data by grade, with the value assignment results being associated with a good or a bad taste; and S5: creating a chart according to the standardized detection results from S4, and describing the taste of the wine according to the chart.

Abstract: Methods for identifying or diagnosing AKT inhibitor resistant cancers and methods an compositions for treating.

Abstract: A media management system including an application layer, a system layer, and a solid state drive (SSD) storage layer. The application layer includes a media data analytics application configured to assign a classification code to a data file. The system layer is in communication with the application layer. The system layer includes a file system configured to issue a write command to a SSD controller. The write command includes the classification code of the data file. The SSD storage layer includes the SSD controller and erasable blocks. The SSD controller is configured to write the data file to one of the erasable blocks based on the classification code of the data file in the write command. In an embodiment, the SSD controller is configured to write the data file to one of the erasable blocks storing other data files also having the classification code.

Abstract: The present invention relates to a method and system for quantitative defacing of a QR Code. Defacing of the method includes data and error correction code word defacing, boundary defacing, position detection pattern defacing, correction pattern defacing, positioning pattern defacing, version information defacing, and format information defacing. Quantitative defacing varies with the defacing patterns and positions of a barcode. The defacing degree of the QR Code is not greater than the capability of the barcode for correcting error codes. The number of coding characters of the QR Code is required to be equal to the character number of a data code word which is specified by a current barcode version and correction grade, and the situation of adding filling characters does not exist. Defacing of the data and error correction code words does not include defacing of remaining bits. Defacing patterns include pre-stage printing defacing and rear-stage actual defacing.

Abstract: Provided herein are biomarkers, and combinations of biomarkers, for predicting sensitivity to cancer treatments.

Abstract: Methods for identifying or diagnosing AKT inhibitor resistant cancers and methods an compositions for treating.

Abstract: In one embodiment, a method of serving media includes receiving a request to serve a cacheable media content to a user equipment at a second media server deployed in a second layer2 access network. The request is received around when the user equipment is handed-off from a first layer2 node in a first layer2 access network to a second layer2 node in the second layer2 access network and when a streaming session of the cacheable media content to the user equipment from a first media server is terminated. The method further includes determining if the cacheable media content is stored in a cache of the second media server, and serving the cacheable media content from the cache of the second media server to the user equipment if the media content is stored in the cache of the second media server.

Abstract: The invention provides combinations comprising a) compound of formula I: or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: A media management system including an application layer, a system layer, and a solid state drive (SSD) storage layer. The application layer includes a media data analytics application configured to assign a classification code to a data file. The system layer is in communication with the application layer. The system layer includes a file system configured to issue a write command to a SSD controller. The write command includes the classification code of the data file. The SSD storage layer includes the SSD controller and erasable blocks. The SSD controller is configured to write the data file to one of the erasable blocks based on the classification code of the data file in the write command. In an embodiment, the SSD controller is configured to write the data file to one of the erasable blocks storing other data files also having the classification code.

Abstract: Methods for identifying or diagnosing AKT inhibitor resistant cancers and methods an compositions for treating.

Abstract: In one embodiment, a method of serving media includes receiving a delivery log of traffic use after every first time interval for an user equipment. The user equipment is part of a hot billing class of users. The traffic use comprises data usage by the user equipment during communication with a media server in a layer2 access network. A user traffic information computed from the delivery log is transmitted to a billing center. A account status information is received from the billing center. The account status information is received if the user equipment exceeds a user account metric. A session termination information based on the account status information is transmitted.

Abstract: In one embodiment, a method of serving media includes receiving a request to serve media content to an user equipment, and receiving caching information regarding the media content. The caching information includes information regarding whether the media content requested by the user equipment is cacheable. A first media server is assigned from a hierarchical set of media servers to serve the user equipment if the media content to be served is cacheable. The hierarchical set of media servers includes a plurality of first type of media servers deployed in a plurality of layer2 (L2) access networks. The user equipment is coupled to the content delivery network through a layer2 access network of the plurality of L2 access networks.

Abstract: The invention provides combinations comprising a) compound of formula I: or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: The invention provides combinations comprising a) compound of formula I: (formula I), or a pharmaceutically acceptable salt thereof; and another agent selected from GDC-0973, PD-0325901, or a pharmaceutically acceptable salt thereof. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: The invention provides combinations comprising a) compound of formula I: or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.