Abstract: The invention provides combinations comprising a) compound of formula I: or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: In one embodiment, a method of serving media includes receiving a delivery log of traffic use after every first time interval for an user equipment. The user equipment is part of a hot billing class of users. The traffic use comprises data usage by the user equipment during communication with a media server in a layer2 access network. A user traffic information computed from the delivery log is transmitted to a billing center. A account status information is received from the billing center. The account status information is received if the user equipment exceeds a user account metric. A session termination information based on the account status information is transmitted.

Abstract: In accordance with an embodiment of the present invention, a method of streaming a media preview includes delivering a preview data having preview information from a media file to be streamed. The preview data has a multi-dimensional hierarchical data structure has a plurality of layers with increasing content of the preview information in each layer of the plurality of layers. The preview data is configured to provide an adaptive and scalable preview service.

Abstract: Provided herein are biomarkers, and combinations of biomarkers, for predicting sensitivity to cancer treatments.

Abstract: In one embodiment, a method of serving media includes receiving a request to serve a cacheable media content to a user equipment at a second media server deployed in a second layer2 access network. The request is received around when the user equipment is handed-off from a first layer2 node in a first layer2 access network to a second layer2 node in the second layer2 access network and when a streaming session of the cacheable media content to the user equipment from a first media server is terminated. The method further includes determining if the cacheable media content is stored in a cache of the second media server, and serving the cacheable media content from the cache of the second media server to the user equipment if the media content is stored in the cache of the second media server.

Abstract: In one embodiment, a method of serving media includes receiving user profiles from a layer3 node in an access network, and receiving a request to serve media content to a user equipment. The user profiles include information relating to user account and/or network characteristics of the user equipment. The method further includes using an user equipment information from the user profiles, assigning a first media server from a hierarchical set of media servers to serve the user equipment if the media content to be served is cacheable. The hierarchical set of media servers include a plurality of first type of media servers deployed in a plurality of layer2 (L2) access networks. The user equipment is coupled to a content delivery network through a layer2 access network of the plurality of layer2 access networks.

Abstract: In accordance with an embodiment of the present invention, a method of streaming media with a media preview includes generating a preview data by extracting preview information from a media file to be streamed. The preview data has a multi-dimensional hierarchical data structure having a plurality of layers with increasing content of the preview information in each layer of the plurality of layers. The preview data is configured to provide a differentiated preview service.

Abstract: In one embodiment, a method of serving media includes receiving a request to serve a cacheable media content to a user equipment at a second media server deployed in a second layer2 access network. The request is received around when the user equipment is handed-off from a first layer2 node in a first layer2 access network to a second layer2 node in the second layer2 access network and when a streaming session of the cacheable media content to the user equipment from a first media server is terminated. The method further includes determining if the cacheable media content is stored in a cache of the second media server, and serving the cacheable media content from the cache of the second media server to the user equipment if the media content is stored in the cache of the second media server.

Abstract: The invention provides combinations comprising a) compound of formula I: or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: In one embodiment, a method of serving media includes receiving user profiles from a layer3 node in an access network, and receiving a request to serve media content to a user equipment. The user profiles include information relating to user account and/or network characteristics of the user equipment. The method further includes using an user equipment information from the user profiles, assigning a first media server from a hierarchical set of media servers to serve the user equipment if the media content to be served is cacheable. The hierarchical set of media servers include a plurality of first type of media servers deployed in a plurality of layer2 (L2) access networks. The user equipment is coupled to a content delivery network through a layer2 access network of the plurality of layer2 access networks.

Abstract: Methods for identifying or diagnosing AKT inhibitor resistant cancers and methods an compositions for treating.

Abstract: In accordance with an embodiment of the present invention, an apparatus for streaming a media includes a server side receiver for receiving a request to stream a media from a media player. The apparatus further includes a content generator, a server side transmitter, and a media stream generator. The content generator is configured to generate content information providing a plurality of presentation options to consume the media. The server side transmitter is configured to send the content information. The server side receiver is further configured to receive a selected presentation option from amongst the plurality of presentation options. The media stream generator is configured to generate a media stream comprising the media based on the selected presentation option.

Abstract: Computing systems and methods to producing a reverse time migration model dip-guided image using processed vertical seismic profile data are provided. In one embodiment, vertical seismic profile data for a subsurface geological formation is obtained. One or more dip estimates corresponding to the subsurface geological formation are also obtained. One or more model dip-guided reverse time migration imaging conditions are determined and applied to the obtained vertical seismic profile data to produce the processed vertical seismic profile data.

Abstract: In one embodiment, a method of serving media includes receiving a request to serve media content to an user equipment, and receiving caching information regarding the media content. The caching information includes information regarding whether the media content requested by the user equipment is cacheable. A first media server is assigned from a hierarchical set of media servers to serve the user equipment if the media content to be served is cacheable. The hierarchical set of media servers includes a plurality of first type of media servers deployed in a plurality of layer2 (L2) access networks. The user equipment is coupled to the content delivery network through a layer2 access network of the plurality of L2 access networks.

Abstract: In accordance with an embodiment of the present invention, a method of playing a media includes receiving a first media stream of the media and displaying the first media stream in a first window of a media player. The first media stream includes navigable parts configured to be selected for higher resolution streaming. A request to stream a selected navigable part of the first media stream is sent. A second media stream with the selected navigable part is received and displayed. The resolution of the selected navigable part in the second media stream is higher than the resolution of the selected navigable part in the first media stream.

Abstract: In one embodiment, a method of serving media includes receiving a request to serve media content to an user equipment, and receiving caching information regarding the media content. The caching information includes information regarding whether the media content requested by the user equipment is cacheable. A first media server is assigned from a hierarchical set of media servers to serve the user equipment if the media content to be served is cacheable. The hierarchical set of media servers includes a plurality of first type of media servers deployed in a plurality of layer2 (L2) access networks. The user equipment is coupled to the content delivery network through a layer2 access network of the plurality of L2 access networks.

Abstract: The invention provides combinations comprising a) compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: The invention provides combinations comprising a) compound of formula I: (formula I), or a pharmaceutically acceptable salt thereof; and another agent selected from GDC-0973, PD-0325901, or a pharmaceutically acceptable salt thereof. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: Methods for predicting sensitivity to cancer treatments by assessing biomarkers and combinations of biomarkers include evaluating the presence of mutations to Akt, wherein the presence of said mutations correlates with the sensitivity of Akt inhibitors.

Abstract: A media management system including an application layer, a system layer, and a solid state drive (SSD) storage layer. The application layer includes a media data analytics application configured to assign a classification code to a data file. The system layer is in communication with the application layer. The system layer includes a file system configured to issue a write command to a SSD controller. The write command includes the classification code of the data file. The SSD storage layer includes the SSD controller and erasable blocks. The SSD controller is configured to write the data file to one of the erasable blocks based on the classification code of the data file in the write command. In an embodiment, the SSD controller is configured to write the data file to one of the erasable blocks storing other data files also having the classification code.