Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: A personalized non-invasive blood glucose measurement method according to the present disclosure includes: (a) collecting blood glucose value data of a patient by a processor unit; (b) determining an acceptable final error E? with the blood glucose value data collected by the processor unit; (c) non-invasively predicting a blood glucose value in accordance with a setting mode by a patient when the final error E? is determined, to measure a blood glucose value, by the processor unit; (d) periodically determining whether the final error E? is calibrated by the processor unit; and (e) when it is not necessary to recalibrate in step (d), non-invasively predicting the blood glucose value in the range of the final error E? determined in step (b) to measure the blood glucose value, to non-invasively provide an accurate personalized blood glucose value to a patient who needs to invasively measure a blood glucose every day.

Abstract: Exemplary embodiments provide systems and methods for determining performance metrics or statistics relating to relational databases that are accessed remotely. Such embodiments may automatically discover the presence or identity of such remotely-stored databases using serverless code, query each database for performance information, convert the performance information into performance metrics, and store the performance metrics as time-series data in a time-series database. The performance metrics may be used to generate notifications, provide input to a machine learning process, adjust settings of the relational databases or an associated service, or provide a visualization of the performance of the databases, among other possibilities.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: A system including: a processor; and a memory storing computer program code that controls the processor to: collect real-time business process metrics; collect real-time cluster metrics for a plurality of application clusters indicative of a required allotment of infrastructure resources for a given business process level; estimate a predicted future business process level; based on the estimated predicted future business process level and the real-time cluster metrics, predict a future infrastructure resource requirement of each of the plurality of application clusters; compare the predicted future infrastructure resource requirement of each of the plurality of application clusters to a current dedication of each of the plurality of application clusters; automatically adjust, in real-time and based on the comparison, respective allotments of infrastructure resources for each of the plurality of application clusters; receive an actual business process; and process the business process across the plurality of

Abstract: A system and method of monitoring a powder-bed additive manufacturing process is provided where a layer of additive powder is fused using an energy source and electromagnetic emission signals are measured by a melt pool monitoring system to monitor the print process. The measured emission signals are analyzed to identify outlier emissions and clusters of outliers are identified by assessing the spatial proximity of the outlier emissions, e.g., using clustering algorithms, spatial control charts, etc. An alert may be provided or a process adjustment may be made when a cluster is identified or when a magnitude of a cluster exceeds a predetermined cluster threshold.

Abstract: In accordance with embodiments of the present disclosure, an information handling system may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the processor to (i) read plug-in configuration data setting forth data regarding user interface modifications to be made to a user interface of a management console application; (ii) based on the plug-in configuration data, call one or more pluggable modules; and (iii) integrate user interface features defined by the plug-in configuration data and the one or more pluggable modules into the user interface of the management console application.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: The present disclosure provides a method and system of magnetic resonance imaging using a constrained gradient waveform. The constrained gradient waveform is designed to have only predetermined frequencies, for example excluding one or more identified resonant frequencies associated with the MRI system. The application of such a constrained gradient waveform during imaging may aid in reducing noise, vibration and/or heating of the MRI system during imaging.

Abstract: A device may receive data for a plurality of metrics from a set of server resources associated with hosting an application. The plurality of metrics may be related to a performance of the set of server resources. The data may be time series data. The device may normalize the data for the plurality of metrics across a set of points in time to form normalized data. The device may determine a score for the performance of the set of server resources associated with hosting the application at a particular point in time based on the normalized data. The score may be used to determine whether an anomaly is present in the performance of the set of server resources at the particular point in time. The device may perform an action to facilitate improvement of the performance of the set of server resources based on the score satisfying a threshold.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: In one embodiment, a system includes a gas turbine system, having: a turbine driven by combustion products produced by a turbine combustion system; and a separation unit positioned between turbine stages of the turbine, wherein the separation unit separates oxygen out of the combustion products. The separation unit may include an ion transport membrane.

Abstract: The present disclosure provides a method and system of magnetic resonance imaging using a constrained gradient waveform. The constrained gradient waveform is designed to have only predetermined frequencies, for example excluding one or more identified resonant frequencies associated with the MRI system. The application of such a constrained gradient waveform during imaging may aid in reducing noise, vibration and/or heating of the MRI system during imaging.

Abstract: A device may receive data for a plurality of metrics from a set of server resources associated with hosting an application. The plurality of metrics may be related to a performance of the set of server resources. The data may be time series data. The device may normalize the data for the plurality of metrics across a set of points in time to form normalized data. The device may determine a score for the performance of the set of server resources associated with hosting the application at a particular point in time based on the normalized data. The score may be used to determine whether an anomaly is present in the performance of the set of server resources at the particular point in time. The device may perform an action to facilitate improvement of the performance of the set of server resources based on the score satisfying a threshold.

Abstract: Technologies for converting mobile communications network billing records include a billing record converter system. The billing record converter system receives a data usage billing record associated with a mobile computing device communicatively coupled to a long term evolution wireless communications network. The received data usage billing record is formatted according to a real-time data usage billing record format. The received data usage billing record is converted into a new data usage billing record formatted according to a roaming data usage billing record format that corresponds to a legacy wireless communications network. The new data usage billing record is transmitted to a billing system of the legacy wireless communications network for processing. In some embodiments, the billing record converter system cumulates and converts multiple data usage billing records associated with the mobile computing device into the new data usage billing record. Other embodiments are described and claimed.

Abstract: In accordance with embodiments of the present disclosure, an information handling system may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the processor to (i) read plug-in configuration data setting forth data regarding user interface modifications to be made to a user interface of a management console application; (ii) based on the plug-in configuration data, call one or more pluggable modules; and (iii) integrate user interface features defined by the plug-in configuration data and the one or more pluggable modules into the user interface of the management console application.

Abstract: Techniques for providing a secure Fine Timing Measurement (FTM) exchange between two wireless transceivers are disclosed. An example of a method according to the disclosure include transmitting a protected FTM range request message with a Dialog Token of a FTM frame, receiving a protected FTM range report message from a station, wherein the protected FTM range report message includes FTM information, and authenticating the station based at least in part on the FTM information included in the protected FTM range report message.