Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: A safety bumper for a vehicle constructed from a lattice of interlocking panels (1). The panels are formed in an overall substantive V, D or triangular shape such that when vehicle collide they are deflected from each other and, moreover, the bumper lattice crumples to give a progressive deceleration which reduces the risk of injury or death to passengers in the vehicle.

Abstract: An integrated gasification combined cycle (IGCC) system involving CO2 capture is provided comprising a CO2-selective membrane, a pre-compressor, and a sulfur gas removal system to selectively remove H2S and CO2 from shifted syngas, wherein the pre-compressor increases the permeate stream from the CO2-selective membrane from a first pressure to a second pressure prior to entering the sulfur removal system. Also provided herein is a method of maintaining a substantially constant pressure in a sulfur removal system, comprising introducing a feed gas stream to a CO2-selective membrane for separation into a syngas rich stream and a permeate gas stream, wherein the permeate gas stream is at a first pressure; increasing the permeate gas stream from the first pressure to a second pressure; and introducing the permeate gas stream at the second pressure to a sulfur removal system downstream of the pre-compressor.

Abstract: The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.

Abstract: A position calculation method and apparatus are described. The position calculation apparatus may include an inertial measurement unit and be configured to be coupled with at least one sensor unit for detecting a physical event for use in position calculation. The presence of and type sensor unit may identified, and the position processing to be undertaken may depend on this identification.

Abstract: The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: A position calculating method includes: executing position calculation processing using a plurality of Kalman filter processing, which is processing corresponding to each of a plurality of power spectral density groups classified by performing in advance frequency analysis on the movement acceleration of a movable body as an object of position calculation and which includes an error parameter set to a different value according to the power spectral density group and a parameter indicating that the movable body is in a uniform motion state, on the basis of a satellite signal from a positioning satellite; and determining the position of the movable body using a position calculated by each Kalman filter processing.

Abstract: A precision information collating device is disclosed. The device comprises means for inputting keywords and key phrases and defining level of traverse for establishing interlinks and interdependencies between keywords and key phrases entered and using previously stored interlinks and interdependencies to form a map. The device facilitates searching for keywords and key phrases and filtering out unwanted results, indexing, rating and posting of the result obtained and means for browsing the result.

Abstract: A position calculating method includes: calculating a position of a mobile body based on a positioning signal from a positioning satellite; determining the moving condition of the mobile body based on a detection result of a sensor unit including at least one of an acceleration sensor, an angular speed sensor, and an azimuth sensor; changing an error parameter used for a predetermined Kalman filter process according to the determined moving condition; and correcting the calculated position by the Kalman filter process.

Abstract: A position calculating method performed by a position calculating device having a sensor unit carried by or mounted on a mobile body and moving with the mobile body, includes: calculating the position of the mobile body; setting a detection value agreement range of the sensor unit for each of the possibility of moving, possibility of uncertainty, and possibility of stopping of the mobile body, and setting the detection value agreement range of the possibility of moving as the widest range to establish a membership function; determining whether the mobile body is in the stopping condition by predetermined fuzzy inference calculation using the membership function; changing an error parameter used for predetermined Kalman filter process to correct the calculated position by the Kalman filter process according to whether the stopping condition of the mobile body is determined or not; and correcting the calculated position by the Kalman filter process.

Abstract: This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

Abstract: A protection apparatus for a circuit breaker disposed in a circuit to be protected uses a solenoid configured to operate the circuit breaker on command, an undervoltage release (UVR) sensing apparatus configured to produce an UVR signal in response to a line voltage of the circuit to be protected falling below a predetermined level, and a shunt trip (ST) sensing apparatus configured to produce a ST signal when it senses a ST command. A controller operably connected to the UVR sensing apparatus, the ST sensing apparatus, and the solenoid, is configured to receive the UVR and ST signals when produced and controls the solenoid to open the breaker in response to receipt by the controller of either of the UVR and ST signals.

Abstract: A system for automation of processes in a working environment to achieve targeted deliverables, said system comprising: mapping means adapted to map discrete processes in a working environment; reader means adapted to read human instructions in relation to targeted deliverables at mapped discrete processes; interpreter means adapted to interpret said read instructions into a machine readable instruction format; compiler means adapted to compile said machine readable instruction format into a pre-defined operating system executable instruction format; packager means adapted to classify and package said operating system executable instruction format in a pre-defined format; and installer means adapted to install and deploy said packaged format in said working environment to complete the automation process and achieve targeted deliverables.

Abstract: A method is provided for hydrolyzing polysaccharides in a lignocellulosic feedstock to produce monosaccharides or pretreating a lignocellulosic feedstock, in which an aqueous slurry of the lignocellulosic feedstock is fed into a pressurized dewatering zone wherein the feedstock is partially dewatered and then is compressed into a plug. The plug is introduced into a reaction zone that operates at a pressure (Pr) equal to greater than about 90 psia and under suitable temperature and pH conditions to hydrolyze the polysaccharides or pretreat the feedstock. The plug provides a pressure seal between the outlet of the dewatering zone and the reaction zone. The pressure (Pdwi) of the aqueous slurry of the lignocellulosic feedstock at the inlet of the dewatering device is related to Pr as follows: 0??P<the lesser of [(Pr?20 psia) and 220 psia], and where ?P is the absolute difference in pressure between Pr and Pdwi in psia.

Abstract: A circuit breaker closing actuator and a method of operation is provided. The closing actuator is disposed to communicate and receive signals from a trip unit. The trip unit includes a communications to transmit and receive data and signals from a remote location. The trip unit transmits a signal to the closing actuator in response to receiving a closing signal from the remote location. The closing actuator validates the signal and activates a driving circuit if the signal is validated. The driving circuit enables power to a solenoid that closes the circuit breaker.