Abstract: Composite nanomaterials including a carbon nanomaterial and an electrocatalyst are disclosed and shown to facilitate enhanced detection, via electro-oxidation, of phenolic analytes when applied to a sensing electrode, such as the working electrode of an electrochemical sensor. In other example embodiments, methods and devices for improved electrochemical detection of phenolic analytes are disclosed in which a sensor electrode is modified by the presence of graphene nanosheets. Such modified electrodes may be employed to provide working electrodes in electrochemical sensors for the rapid detection of cannabinoids and/or associated metabolites in saliva. In some example implementations, the nanocomposite or graphene nanosheets are functionalized with magnetic particles and provided in a suspension that is initially contacted with the sample prior to being magnetically drawn to the surface of the electrode for electrochemical processing.

Abstract: Pharmaceutical compositions comprising oil as a vehicle, a suspending agent, and a surfactant are disclosed to be used in conjunction with active pharmaceutical ingredients which are water soluble or insoluble, or which are sensitive to water but insoluble in oil. Such active pharmaceutical ingredients may include temozolomide, lenalidomide, Oxaliplatin, Cisplatin, Carboplatin, 5-fluorouracil, irinotecan, topotecan, cyclophosphamide, doxorubicin, vincristine, vinblastine, Melphalan, Chlorambucil, Dacarbazine, Daunorubicin, Epirubicin, Mitoxantrone, Etoposide, Teniposide, Azacitidine, Cytarabine, Gemcitabine, vinoralbine, Pemetrexed, a derivative thereof, or a combination thereof. The pharmaceutical compositions may be administered as an oral suspension. Other embodiments are directed towards methods of using and methods of making such formulations.

Abstract: This disclosure provides crystalline polymorphs of squalamine phosphate, methods of making the same, and methods of treatment using the same.

Abstract: A method includes generating a reference voltage by periodically switching direction of current flow in a diagnostic sensor, where the reference voltage is a non-sinusoidal differential voltage of which an amplitude alternates between minimum and maximum values, and where the reference voltage includes a diagnostic sensor output voltage component responsive to an external magnetic field and a diagnostic sensor offset voltage component responsive to a mismatch of the diagnostic sensor. The method also includes amplifying the reference voltage to produce an amplified reference voltage, where the amplified reference voltage is a differential voltage having an amplifier offset voltage component. Additionally, the method includes demodulating the amplified reference voltage by filtering the diagnostic sensor offset voltage component and the amplifier offset voltage component to produce a demodulated voltage. Also, the method includes digitizing the demodulated voltage to produce a digitized voltage.

Abstract: A system may comprise: a contactless sensor configured to couple to a waste tank; a controller electronically coupled to the contactless sensor, the controller configured to: receive, via the contactless sensor, a waste water level data from the contactless sensor, calculate a waste water level based on the waste water level data.

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.

Abstract: Disclosed herein are personal protective equipment (PPE) storage, dispensing, and/or donning systems, devices, and methods for using same. In many embodiments, the disclosed storage, dispensing, and/or donning systems, devices, and methods include one or more devices or sub-systems for monitoring PPE stored at or in the system. In many embodiments, the storage, dispensing, and/or donning system may include one or more indicator for aiding a user in selecting items of PPE. Also disclosed are protective gowns for use with the disclosed storage, dispensing, and/or donning systems, wherein the gowns may include one or more features or structures to aid in storing, dispensing, or donning the gown.

Abstract: A perfusion container for directly administering to patients a dose of an antineoplastic drug calculated according to a patient's parameter, wherein the first perfusion container comprises a solution of antineoplastic drug at a concentration and volume such that the amount of antineoplastic drug in the container is equal to the calculated dose for one patient but less than the calculated dose for a second patient, the calculated dose is provided to first patient within 5% variance by directly administering the full volume of the solution of antineoplastic drug from the first perfusion container, further the first perfusion container is accompanied by a second top-up perfusion container comprising a solution of antineoplastic drug at a concentration and volume such that the calculated dose is provided within 5% variance by directly administering the full volume of the solution of antineoplastic drug from the first perfusion container and the second top-up container to the second patient.

Abstract: Described are short interfering nucleic acid (siNA) molecules comprising modified nucleotides, compositions, and methods and uses thereof.

Abstract: A system includes an adapter mounted over a distal end of an insertion device, a clip and a first extending member. The clip includes jaws movable between an insertion configuration, with the jaws separated and an initial deployed configuration with the jaws drawn together. The clip is biased toward the initial configuration. The first jaw includes a connection element and a first member releasably coupled to the first jaw connection element permits movement of the adapter relative to the clip while the first member remains coupled to the clip to enhance visual observation of the clip. The first member retracts the clip proximally over the adapter so that the clip is forced open as the clip is retracted over the adapter freeing the clip from tissue on which it had been clipped.

Abstract: Systems and methods for remotely monitoring hospital patients are provided. Medical devices may capture biometric data associated with a patient positioned in an ICU environment, and a remote display device positioned external to the ICU environment may display an indication of the health of the patient based on the captured biometric data. The indication of the health of the patient may include a graph mapping normalized health statuses associated with the patient over time. Each normalized health status may be based on normalizing a particular type of biometric data based on a medical protocol, so each data point of the graph includes an indication of a normalized health status associated with the patient at a given time. The indication of the health of the patient may include an animated three-dimensional that is dynamically updated to reflect biometric data associated with the patient captured at a time selected by a user.

Abstract: The present invention relates to the treatment of myeloproliferative neoplasms through targeted elimination of malignant clones and overcome of diseases persistence. The treatment is based on a combination of inhibitors of mRNA splicing and processing factors together with Jak inhibitors.

Abstract: A vehicular driver assist system includes a forward-viewing camera disposed at and viewing through a windshield of a vehicle. The vehicular driver assist system sets an initial vehicle soft lock speed when speed of the vehicle reaches an initial threshold speed of travel. With the initial vehicle soft lock speed set and with the vehicle speed exceeding the initial vehicle soft lock speed, the system maintains the vehicle speed at the initial vehicle soft lock speed when the vehicle speed reduces to the initial vehicle soft lock speed by coasting. When speed of the vehicle increases by a multiple of a vehicle speed increment above the initial vehicle soft lock speed, the system sets an increased vehicle soft lock speed and maintains the vehicle speed at the increased vehicle soft lock speed when the vehicle speed reduces to the increased vehicle soft lock speed by coasting.

Abstract: The present invention provides oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof, which is useful for the treatment of HIV infections. Further the present invention provides composition and process for preparing oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to extended-release suspension composition. The present invention specifically relates to extended-release suspension composition comprising active ingredient and pharmaceutically acceptable excipients, wherein said composition is in the form of powder for suspension or a ready to use suspension. The present invention specifically relates to extended-release suspension composition comprising active ingredient and pharmaceutically acceptable excipients, wherein said composition is devoid of uncoated active ingredient-ion exchange resin complex portion and polyvinyl acetate. The present invention also relates to extended-release suspension composition comprising one or more functional barrier coatings on active ingredient-ion exchange resin complex, wherein said functional barrier coatings comprises hypromellose and/or talc.

Abstract: Methods, systems, and devices related to data relocation via a cache are described. In one example, a memory device in accordance with the described techniques may include a memory array, a sense amplifier array, and a signal development cache configured to store signals (e.g., cache signals, signal states) associated with logic states (e.g., memory states) that may be stored at the memory array (e.g., according to various read or write operations). In some cases, the memory device may transfer data from a first address of the memory array to the signal development cache. The memory device may transfer the data stored in the signal development cache to a second address of the memory array based on a parameter associated with the first address of the memory array satisfying a criterion for performing data relocation.

Abstract: Systems and methods are described herein for generating a playlist for a simultaneous presentation of a plurality of media assets. The system retrieves a user preference associated with a user profile and receives a selection of a first media asset and a second media asset from the plurality of media assets for presentation on a user device. The system parses the respective audio streams of the first media asset and the second media asset to identify one or more preferred audio segments based on the user preference and generates the playlist of the identified one or more preferred audio segments. Based on a generated audio playlist, the system generates, for presentation on the user device, the video stream for each of the first media asset and the second media asset and the playlist of the identified one or more preferred audio segments.

Abstract: Aspects of the present disclosure include methods, systems, and non-transitory computer readable media that perform the steps of receiving a visual code identifier associated with a transaction of one or more transaction merchandises, receiving a radio frequency identification (RFID) identifier associated with the transaction, analyzing the image, determining at least one of one or more detected merchandises, a number of the one or more detected merchandises, and a price of the one or more detected merchandises based on information in the RFID identifier and the analyzed image, determining a merchandise discrepancy, a number discrepancy, or a price discrepancy, and transmitting, in response to determining the at least one of the merchandise discrepancy, the number discrepancy, or the price discrepancy, an alert.

Abstract: An illustrative room identification system performs augmented reality room identification based on free-hand image capture and room-object profile data. The room identification system obtains a set of reference room-object profiles for a set of rooms associated with an experience presented by an augmented reality presentation device. The room identification system generates a live room-object profile based on an image captured by the presentation device during the augmented reality experience, the image depicting a particular room of the set of rooms. Based on the live room-object profile and the set of reference room-object profiles, the room identification system determines that the presentation device is located in the particular room of the set of rooms and provides, to the presentation device, an indication of the determination that the presentation device is located in the particular room. Corresponding methods and systems are also disclosed.

Abstract: A card engine may dynamically configure content for display via user equipment (UE). A rules engine may provide constructs to the card engine in the form of card definitions, which the card engine may evaluate using facts obtained from a facts controller. The card engine may create a hierarchy of containers, which are logical abstracts for containing cards. The containers in the hierarchy, which may be organized as a tree, may contain card definitions according to respective themes determined by the card engine. Variants may be assigned weights which can be changed dynamically based on factors such as user behavior, account condition, promotions or offerings. The card having the highest weight within its container is advanced up the tree. When a card reaches the top level of the tree, it may be formatted for display via the user interface and transmitted to the UE accordingly.