Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.

Abstract: The present invention relates to a process for the preparation of tapentadol and analogs or compounds or stereoisomers of formula (I), Formula I wherein, A is aryl, heteroaryl, and cycloalkyl; R is H, OH, OR1, halogen, C1-C12 alkyl, cycloalkyl, aryl or heteroaryl; R1 is C1-C12 alkyl, cycloalkyl, aryl or heteroaryl, wherein each of these groups may further be substituted with one or more substituent selected from H, OH, halogen, CN, NO2, C1-C4 alkyl or phenyl. Further, the multi-step process involves no column chromatography purification until the very last step. This makes this process highly commercially viable and industrially useful.

Abstract: Systems and methods are described herein for novel uses and/or improvements for predicting, using machine learning models, a process for a user based on function execution. An indication of completion of a predetermined application function associated with a user may be detected and a plurality of stored parameters associated with the user may be identified. The predetermined application function and the parameters may be input into a machine learning model to determine/obtain a process prediction for the user. The process may include a number of functions that may be sent to a user device for execution.

Abstract: Apparatuses, systems, and methods for a user equipment device (UE) to perform methods for enhancement of multi-SIM devices, such as UE 106. A network may increase paging retries for known MU-SIM devices, e.g., based on an indication of capabilities from a MU-SIM device. The indication may be via a NAS registration request, an RRC capability procedure, and/or an RRC UE assistance procedure. Additionally, a network may include an indication of a paging priority to the UE. The UE may then determine a response to the page based, at least in part, on the indicated priority. Further, the UE may indicate a tune-away to the network. The indication of the tune-away may include a cause and/or duration for the tune-away and may be provided at an RRC level or a network access stratum (NAS) level.

Abstract: Aspects of the disclosure relate to computing platforms that utilize improved mitigation analysis and policy management techniques to improve onboarding security. A computing platform may determine that a predetermined period of time has elapsed since finalizing an onboarding process. The computing platform may receive spot check verification inputs indicative of a user identity and may direct a mitigation analysis and output generation platform to analyze the spot check verification inputs. The computing platform may receive an indication of a correlation between the spot check verification inputs and expected spot check verification inputs. In response to determining that the correlation exceeds a predetermined threshold, the computing platform may determine that an additional verification test should be conducted, and may direct the mobile device to display an interface that prompts for additional onboarding verification inputs.

Abstract: A computing device is provided, including a storage device configured to store image data and a processor coupled to a memory that stores instructions, which, upon execution by the processor, cause the processor to select a target image from the image data. The processor is further configured to display conversion possibility information that indicates that the target image can be converted into a larger image that has a larger field of view by stitching other images together with at least a portion of the target image and an associated selector. The processor is further configured to display the larger image upon receiving a user selection of the selector.

Abstract: A system and method for hydraulic fracturing a subterranean formation with fracturing fluid to generate fractures, and intermittently adjusting a characteristic of the fracturing fluid conveying proppant to form pillars of proppant in the fractures.

Abstract: A circumaural headset having a first earcup and a second earcup can include a first transducer disposed with the first earcup and configured to transmit a first non-audible signal with an audible signal, a second transducer disposed within the second earcup and configured to receive the first non-audible signal from the first transducer, and an off-ear detection processor configured to determine whether the headset has been removed from the user's head based on the second transducer receiving the first non-audible signal from the first transducer.

Abstract: Disclosed are bioavailable solid state (17-?)-Hydroxy-4-Androsten-3-one esters suitable for pharmaceutical uses and administration to mammals in need of (17-?)-Hydroxy-4-Androsten-3-one. Pharmaceutical compositions and the dosage forms of the bioavailable solid state (17-?)-Hydroxy-4-Androsten-3-one esters can be used to treat any condition associated with testosterone deficiency, including complete absence of endogenous testosterone in male or female subjects.

Abstract: An electronic device, method, and computer program product enable a space saving rollable display device to extend automatically in a power efficient manner. While a blade assembly is in a retracted position, a controller of the electronic device determines whether a user notification opportunity exists based on a transition between contextual states of one of stationary and changing from unattended to attended by the user; and stowed on-body of the user changing to held by the user. In response, the controller actuates a translation mechanism to slide a blade assembly, which includes a blade and flexible display, relative to a device housing of an electronic device from a retracted position to at least a partially extended position. The actuation prepares the flexible display to present user notification(s) and generates a physical indication to a user that the user notification(s) is available to be presented when the flexible display is active.

Abstract: In state of the art methods for object goal navigation, scene understanding is implicit in their goal oriented exploration policies. Implicit scene understanding coupled with navigation is shown to be specific to tasks for which training is done and not generalizable to new tasks. Thus, embodiments of present disclosure propose a method of goal-conditioned exploration wherein scene understanding is decoupled from the exploration policies. Here, the scene understanding required for navigation is provided by a region classification network that is trained using semantic graphs representing the scene and agent can be navigated towards the goal either by using any state of the art pure exploration policies or by traversing through potential sub-goals identified based on a Co-occurrence Likelihood score calculated by using predictions from the region classification network. Hence, the method of present disclosure can be easily generalized to new tasks and new environments.

Abstract: A wireless access node detects contention among User Equipment (UEs) for wireless resources. The wireless access node prioritizes individual UEs based on the wireless network slices used by the individual UEs. The wireless access node allocates the wireless resources to the individual UEs based on the prioritization. The wireless access node wirelessly communicates between the wireless network slices and the UEs over the allocated wireless resources.

Abstract: The present specification discloses systems and methods for integrating manifest data for cargo and light vehicles with their X-ray images generated during scanning. Manifest data is automatically imported into the system for each shipment, and helps the security personnel to quickly determine the contents of cargo. In case of a mismatch between cargo contents shown by manifest data and the X-ray images, the cargo may be withheld for further inspection. In one embodiment, the process of analyzing the X-ray image of the cargo in conjunction with the manifest data is automated.

Abstract: In some embodiments, a calibration circuit for an audio amplification system can include a tone generator configured to provide a tone having a frequency to an input path of an audio amplifier, such that an input signal provided to the audio amplifier includes the tone, a a first sampling circuit configured to sample an output signal at an output node of the audio amplifier, and a second sampling circuit configured to sample the input signal at an input node of the audio amplifier. The calibration circuit can further include a gain adjustment circuit configured to generate a correction signal based on the sampled output signal and the sampled input signal to correct for a gain variation of the audio amplifier.

Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.

Abstract: Methods and apparatus to manage workload domains in virtual server racks are disclosed. An example apparatus includes processor circuitry to, in response to detecting that a number of available physical racks satisfies a threshold number of physical racks, apply a first resource allocation technique by reserving requested resources by exhausting first available resources of a first physical rack before using second available resources of a second physical rack; in response to detecting that the number of available physical racks does not satisfy the threshold number of physical racks, apply a second resource allocation technique by reserving the requested resources using a portion of the first available resources without exhausting the first available resources and using a portion of the second available resources without exhausting the second available resources; and execute one or more workload domains associated with a number of requested resources.

Abstract: Traction fluids comprising Formula I, II, III, IV, V, VI, VII or a mixture thereof in combination with a base stock, a viscosity modifier, an anti-foaming agent, and an additive package.

Abstract: A circuit for sensing radiation with high sensitivity is disclosed. The circuit comprises a first transistor configurable to reset a voltage-level at a circuit node to a voltage reference. The circuit also comprises measurement circuitry configured to measure the voltage-level at the circuit node, and at least one photodiode configured to vary the voltage-level at the circuit node in response to radiation incident upon the photodiode during an integration period. The circuit also comprises processing circuitry configured to control the first transistor to reset the voltage-level at the circuit node and to subsequently configure the measurement circuitry to measure the voltage-level at a start and at an end of the integration period.

Abstract: Systems and methods are described for operating a group watching session. In particular, group communications for a group watching session displaying a media content item to multiple users is initiated, one or more communication clusters for the group communication is generated, a user preference of a first user of the multiple users participating in the group communication is determined, and, based on the user preference, the first user is assigned to a first communication cluster of the one or more communication clusters for communication with another of the multiple users.

Abstract: Fiber optic networks, optical network units, and methods of configuring a fiber optic network and an optical network unit using a variable ratio coupler are disclosed. In one embodiment, a fiber optic network includes a feeder optical cable. The first optical network unit and the second optical network unit each includes a variable ratio coupler operable to selectively set a split-ratio among a plurality of split-ratios, and a fiber optic transceiver module. The fiber optic network further includes a first drop cable optically coupling the first optical network unit to the feeder optical cable at a first position, and a second drop cable optically coupling the second optical network unit to the feeder optical cable at a second position. A first split-ratio of the first optical network unit is based on the first position and a second split-ratio of the second optical network unit is based on the second position.