Abstract: A method for generating a behavioral model for a targeted advertisement category (TAC), including: obtaining click stream data including ad-clicks and events preceding the ad-clicks and performed on web pages; assigning features having categories and keywords associated with the web pages to the events; identifying an ad-click of the ad-clicks and a subset of the events preceding the ad-click that result in the ad-click, where the subset of the events is associated with at least one feature; generating an aggregated event sequence by aggregating the ad-click and the subset of the events; selecting, in response to the at least one feature being associated with the TAC, a training data set including at least the aggregated event sequence; generating the behavioral model for the TAC by applying a learning algorithm to a portion of the training data set; and evaluating performance of built models and select model based on performance result.

Abstract: In one aspect, an amorphous alloy comprises Cu, Zr, Be and M. M is at least one element selected from a group consisting of Al, Sn, Si, group IB, group IIB, group IIIB, group IVB, group VB, group VIB, group VIIB and group VIIIB of the element periodic table, provided that the element is not Cu or Zr. In another aspect, an amorphous alloy comprises Cu, Zr, RE and M. RE is at least one element selected from the rare earth elements, M is at least one element selected from a group consisting of Al, Sn, Si, group IB, group IIB, group IIIB, group IVB, group VB, group VIB, group VIIB and group VIIIB of the element periodic table, provided that the element is not Cu, Zr or RE. In yet another aspect, a method for preparing an amorphous alloy comprises melting a raw material comprising Cu, Zr, Be, and M to form an alloy.

Abstract: In one aspect, a Zr-based amorphous alloy comprises Zr, Ti, Cu, Ni, Fe, Be, and Sn. In another aspect, a Zr-based amorphous alloy comprises about 30-75 atomic percent of (ZrxTiySnz), about 10-35 atomic percent of (CumNin), about 0.1-15 atomic percent of Fe, and about 0.1-35 atomic percent of Be. Reference numerals x, y and z are atomic fractions, and x+y+z equals to 1, wherein x is about 0.6-0.85, and z is in the range of about 0.01x-0.1x. Reference numerals m and n are atomic fractions, and m+n equals to 1, and wherein m is about 0.5-0.65. In yet another aspect, a method for preparing a Zr-based amorphous alloy comprises melting a raw material comprising Zr, Ti, Cu, Ni, Fe, Be, and Sn to form an alloy mixture; and molding the alloy mixture to form the amorphous alloy.

Abstract: A switching signal input device for use with an electronic apparatus is provided. The switching signal input device includes a switch part, an operating part and a resilience element, and is capable of performing four-directional switch control actions in response to the elastic forces generated from the resilience element on two planes perpendicular to each other.

Abstract: An electrical connector (100) for receiving a mating plug (5), comprises an insulative housing (1) having a front mating face (111), a mounting face (18), a plurality of side walls (12, 13, 14), and a receiving cavity (15) for receiving the plug and a plurality of passageways (181, 182, 183); a plurality of contacts (21, 22, 23, 24) retained in the passageways and each having a contacting arm and a connecting portion for mounting on a printed circuit board; and a position tab (3) mounted on the housing and extending into the receiving cavity for pressing the plug.

Abstract: The present invention is directed to inhibiting amyloidogenic processing of amyloid precursor protein, and/or inhibiting production of amyloid beta peptides. These methods can involve accelerating cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or contacting a cell with a compound that mimics the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein. The present invention also relates to treating and/or preventing in a subject a degenerative neurological disease characterized by amyloidogenic processing of amyloid precursor protein and/or overproduction of amyloid beta peptide. This method involves administering an agent that accelerates cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or inhibits production of amyloid ? peptides.

Abstract: The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(?)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R1 and R2 represent C1-C4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. Tamsulosin hydrochloride (R1=Et, R2=Me, in its hydrochloride salt form) is an antagonist of ?-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.

Abstract: A method and system for generating a ring map for optical network applications. The method includes sending a first discovery message to a first node through a portion of an optical network. The first node corresponds to a first node identification and a first predetermined identification. The first discovery message includes at least a source node identification associated with a source node, a source predetermined identification associated with the source node, and a first ring connectivity map. Additionally, the method includes if the source node identification and the first node identification are different, updating the first ring connectivity map. Also, the method includes if the source node identification and the first node identification are identical and if the source predetermined identification and the first predetermined identification are different sending a first alarm message.

Abstract: An electrical connector (100) for receiving a mating plug (5), comprises an insulative housing (1) having a front mating face (111), a mounting face (18), a plurality of side walls (12, 13, 14), and a receiving cavity (15) for receiving the plug and a plurality of passageways (181, 182, 183); a plurality of contacts (21, 22, 23, 24) retained in the passageways and each having a contacting arm and a connecting portion for mounting on a printed circuit board; and a position tab (3) mounted on the housing and extending into the receiving cavity for pressing the plug.

Abstract: A method and system for generating a ring map for optical network applications. The method includes sending a first discovery message to a first node through a portion of an optical network. The first node corresponds to a first node identification and a first predetermined identification. The first discovery message includes at least a source node identification associated with a source node, a source predetermined identification associated with the source node, and a first ring connectivity map. Additionally, the method includes if the source node identification and the first node identification are different, updating the first ring connectivity map. Also, the method includes if the source node identification and the first node identification are identical and if the source predetermined identification and the first predetermined identification are different sending a first alarm message.

Abstract: A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

Abstract: A switching signal input device for use with an electronic apparatus is provided. The switching signal input device includes a switch part, an operating part and a resilience element, and is capable of performing four-directional switch control actions in response to the elastic forces generated from the resilience element on two planes perpendicular to each other.

Abstract: A battery ejection mechanism for ejecting a battery housing removably attached to an electrical device housing. The mechanism includes at least one ejection member having a button and an arm. The arm is adapted to transfer a force applied on the button to the electrical device housing to assist in the removal of the battery pack from the electrical device housing. Button motion may also be used to cause retraction of latches mounted on the battery housing.

Abstract: A battery ejection mechanism for ejecting a battery housing removably attached to an electrical device housing. The mechanism includes at least two ejection members, each having a button and an arm. The arms are adapted to transfer a force applied on the buttons to the electrical device housing to provide a pushing force for ejection of the battery pack from the electrical device housing. Force on the buttons also causes associated latches on the battery pack to move to their release position.

Abstract: A pneumatic tire comprising a plurality of wishbone shaped patterns, each comprising a first substantially inclined circumferential groove and a second substantially inclined circumferential groove; and a plurality of curved, substantially lateral grooves, wherein each first substantially inclined circumferential groove and each second substantially inclined circumferential groove is intersected by at least one substantially lateral groove, and each of the inclined circumferential and lateral grooves is perpendicular with the turning axis of the tire.

Abstract: This invention relates to methods of determining the prognosis of a subject with a Pin1 associated disorder by evaluating the levels of phosphorylated Pin1 in a biological sample. The invention also provides Pin1 polypeptides phosphorylated position 16, position 71, or both. The invention further relates to a crystal structure of a pPin1(71) polypeptide and a pPin1(16)(71) polypeptide. The invention also provides constitutively active mutants of Pin1 and modulators that are specific for the molecules. The invention further provides methods for determining if a subject is at risk of developing a Pin1 associated state by determining if a the subject has a mutation in Pin1 that renders the polypeptide constitutively active.

Abstract: The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.

Abstract: The instant invention provides methods for determining if a subject will benefit from treatment with a Pinl modulator based on the expression of Pinl and one or more cancer associated polypeptides, e.g., her2/neu, ras, cyclin Dl, Cdk4, E2F, Myc, Jun, and Rb. The invention further provides methods for determining if a subject will benefit from treatment with one or more cancer treatments, alone or in combination with a Pinl modulator.

Abstract: A battery ejection mechanism for ejecting a battery housing removably attached to an electrical device housing. The mechanism includes at least one ejection member having a button and an arm. The arm is adapted to transfer a force applied on the button to the electrical device housing to provide a pushing force for ejection of the battery pack from the electrical device housing. Force on the button also causes a latch on the battery pack to move to its release position.

Abstract: Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.