Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.

Abstract: A system for granting indefinite use of inactivated software options pre-installed on a device is provided. The system includes receiving, at a remote processing facility, a recurrent use request from a user requesting access to an inactivated software option resident on the device. The system is further configured to validate the request and generate an activation key. The activation key is transmitted from the processing facility to the device automatically activating the option and granting recurrent access. The activation key or code is generated at the processing facility using data from at least one of a user identifier, a system identifier, a recurrent use identifier, and the selected option. A method to permit recurrent use of resident, yet, inactivated software of a device is also provided.

Abstract: A latch includes three circuits. The first circuit drives a first output (QB) to a first level when a first input (D) and a first clock phase (CK) are both low, to a second level when D and CK are both high, and provides high impedance (HI-Z) when different logic levels are applied to D and CK. The second circuit drives a second output (Q) to the first level when a third input (DB) and a complimentary clock phase (CKB) are both low, to the second level when DB and CKB are both high, and provides HI-Z when different logic levels are applied to DB and CKB. The third circuit maintains voltages of Q and QB when the first and second circuits provide HI-Z at Q and QB. Odd-number dividers constructed with such latches produce 50% duty cycle operation without restricting output pulse widths to integer multiples of input periods.

Abstract: A high voltage shift register stage which directly accepts low voltage clock signal inputs without using clock buffers. In particular, a shift register stage circuit is adapted to operate with a low voltage swing clock signal, with the stage circuit having a single state node, a, driven directly. This arrangement allows for reduced power consumption and higher operating speeds.

Abstract: A system and method are provided for requesting remotely enabled access to inactive software options resident on a device. A graphical user interface (GUI) is electronically linked to a centralized facility remotely located from the device. Option identifying parameters, such as a user ID, host ID, system ID, modality selection, and option selection are entered using the GUI and transmitted via an electronic request to the centralized facility. In response to the received request, the centralized facility generates a software key and transmits same to the device for activation of the option if approved by the centralized facility.

Abstract: A high-speed low-power latch includes three sets of transistors. A first set of transistors selects a tracking mode or a holding mode for the latch based on a clock signal having non-rail-to-rail or rail-to-rail voltage swing. A second set of transistors captures a data value based on an input signal and provides an output signal during the tracking mode. A third set of transistors stores the data value and provides the output signal during the holding mode. The input and output signals have rail-to-rail voltage swing. In another aspect, a signal generator includes at least one latch and a control circuit. The latch(es) receive a clock signal and generate an output signal. The control circuit senses a duty cycle of a feedback signal derived from the output signal and generates a control signal to adjust operation of the latch(es) to obtain 50% duty cycle for the feedback signal.

Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

Abstract: A high voltage shift register stage which directly accepts low voltage clock signal inputs without using clock buffers. In particular, a shift register stage circuit is adapted to operate with a low voltage swing clock signal, with the stage circuit having a single state node, a, driven directly. This arrangement allows for reduced power consumption and higher operating speeds.

Abstract: The present invention is related to an exhaust fan, particularly to a fan applied to a personal computer (PC) or computer's power source unit (PSU). The exhaust fan includes base, blade and a second printed circuit board (PCB). The second PCB is disposed on a surface of the blade. A set of induction generator disposed to a joint of the blade joined to the base is electrically connected to the second PCB as a loop. An induced alternate current (AC) turned into direct current (DC) powers the second PCB instead of the mother board power source. Therefore, the low profile fan can be added to the PSU for a low clearance installment.

Abstract: Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided.

Abstract: A high voltage shift register stage which directly accepts low voltage clock signal inputs without using clock buffers. In particular, a shift register stage circuit is adapted to operate with a low voltage swing clock signal, with the stage circuit having a single state node, a, driven directly. This arrangement allows for reduced power consumption and higher operating speeds.

Abstract: Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided.

Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

Abstract: A system and method are provided to remotely activate options resident on a multi-vendor supported device. The technique includes receiving, at a centralized facility, an activation key sent from a first location and configured to activate an option of an in-field device located in a second location, and sending the activation key and a verification script, from the centralized facility, to the in-field device at the second location. The technique also includes receiving, at the centralized facility, a report generated by the verification script and, if the report is satisfactory, installing the activation key in the in-field device to activate the option and, if the report is not satisfactory, aborting activation of the option.

Abstract: A high voltage shift register stage which directly accepts low voltage clock signal inputs without using clock buffers. In particular, a shift register stage circuit is adapted to operate with a low voltage swing clock signal, with the stage circuit having a single state node, a, driven directly. This arrangement allows for reduced power consumption and higher operating speeds.

Abstract: Methods of reducing background during amplification of small amounts of nucleic acids employ careful analysis of sources of low level contamination. Ultraviolet light can be used to reduce nucleic acid contaminants in reagents and equipment. “Primer-dimer” background can be reduced by judicious design of primers. We have shown clean signal-to-noise with as little as starting material as one single human cell (˜6 picogram), E. coli cell (˜5 femtogram) or Prochlorococcus cell (˜3 femtogram).

Abstract: A heater, used in a Liquid Crystal Display (LCD) pixel array that uses a common voltage polysilicon line to supply heat to the pixel elements, instead of using active control transistor input lines, such as gate input lines. The approach permits the display to be activated during the warm-up process.

Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.

Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.