Abstract: The present invention provides, among other things, a masked cytokine comprising an attenuated interleukin 2 (IL-2) polypeptide, a VHH masking moiety, a carrier moiety and anti-PD1 targeting moiety. In some embodiments, the IL-2 polypeptide is engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. The VHH masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e g masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the IL-2 polypeptide becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.

Abstract: A method of manufacturing a multi-part geometric waveguide includes forming a primary prism element and a separate secondary prism element, forming a functional coating over an active surface of the primary prism element, forming a functional coating over an active surface of the secondary prism element, aligning and bonding the primary prism element to a carrier plate, and aligning and bonding the secondary prism element to the carrier plate.

Abstract: A method of manufacturing a micro-molded prism geometric waveguide includes forming a first transflective mirror element and a separate second transflective mirror element, forming a first functional coating over an active surface of the first transflective mirror element, forming a second functional coating over an active surface of the second transflective mirror element, and aligning the first transflective mirror element with the second transflective mirror element to form a microprism array.

Abstract: Fabrication of optical lenses in optical assemblies of small form factor cameras and augmented reality (AR)/virtual reality (VR) near-eye display devices is described. An optical lens may be printed using a three-dimensional printing technique over a substrate such as glass following application of an optically clear adhesive (OCA) layer on the substrate. A buffer layer may also be used between the substrate and the OCA layer. Alternatively, a display waveguide may be used as substrate with a low optical index buffer layer between the OCA layer and the waveguide eliminating an air gap between the optical lens and the waveguide.

Abstract: A method of manufacturing a meniscus lens includes providing an optical lens substrate having a non-planar deposition surface and depositing a resinous layer over the deposition surface to form the lens. Such a printed lens may have a radius of curvature of less than approximately 80 mm, sag of from approximately 2 mm to approximately 20 mm, a maximum thickness of less than approximately 40 mm, and a minimum thickness variation of at least approximately 2 mm.

Abstract: A mold assembly includes a first mold, a second mold, and a lock mounted on one of the first mold or the second mold and releasably coupled with the other of the first mold or the second mold for maintaining a position of the other of the first mold or the second mold relative to the one of the first mold or the second mold while the lock is in a closed position. Also disclosed are a molding apparatus and a method for molding.

Abstract: An apparatus includes a partial reflector, a first lens, a reflective polarizer, and a second lens. The second lens includes a first part and a second part coupled to the first part with at least one optical property designed to correct a specific user's refractive error. Various other apparatuses, systems, and methods of manufacture are also disclosed.

Abstract: Techniques, systems, and assemblies are presented relating to micro spacers positioned between optical substrates. In some embodiments, a stacked optical assembly comprises a first optical substrate having a first index of refraction greater than 1.4, a second optical substrate having a second index of refraction greater than 1.4 and disposed in a stacked position relative to the first optical substrate, and a plurality of micro spacers positioned between the first optical substrate and the second optical substrate. The plurality of micro spacers may maintain a gap having a gap height between the first optical substrate and the second optical substrate. The plurality of micro spacers may be fixedly attached to (a) the first optical substrate, (b) the second optical substrate, or (c) both the first optical substrate and the second optical substrate.

Abstract: According to examples, a lens configuration for a head-mounted display (HMD) device may include a base platform made from glass or plastic, an antenna layer deposited onto the base platform, an optical polymer film deposited onto the antenna layer, and a lens layer deposited onto the optical polymer film through a 3D printing technique. The antenna layer may include a transparent antenna embedded into or deposited onto a transparent layer. The lens layer may be 3D printed as multiple partial layers to have a shape that matches a prescription for the lens layer.

Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.

Abstract: The disclosed apparatus may include a first rigid lens; a second rigid lens, a seal that couples the first rigid lens and the second rigid lens together, where the first rigid lens, the second rigid lens, and the seal define a cavity; and a fluid within the cavity, where the seal is adapted to admit expansions of the fluid within the cavity. Various other apparatuses and methods also disclosed.

Abstract: Methods, systems, and apparatuses for creating or using a multi-layer lens. The processor may create a first layer lens, cool the first layer lens, and combine the first layer lens with a second layer lens to create a multi-layer lens.

Abstract: A device is provided. The device includes a reflective polarizer configured to selectively reflect or transmit a polarized light based on a polarization of the polarized light. The device also includes a display element disposed at a first side of the reflective polarizer, and configured to output a first image light representing a virtual image. The device also includes a polarization switch disposed between the display element and the reflective polarizer, and configured to switch or maintain a polarization of the first image light. The device further includes an active dimming device disposed at a second side of the reflective polarizer, and configured to provide an adjustable transmittance of an input light.

Abstract: The present invention relates to targeted, masked cytokines, comprising a cytokine or functional fragment thereof, a masking moiety, a targeting moiety and a proteolytically cleavable linker. The targeting moiety comprises an antigen-binding moiety that specifically binds to an antigen expressed on the surface of a target cell The masking moiety masks the cytokine or functional fragment thereof thereby reducing or preventing binding of the cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

Abstract: According to examples, a lens configuration for a head-mounted display (HMD) device may include a base platform made from glass or plastic, an antenna layer deposited onto the base platform, an optical polymer film deposited onto the antenna layer, and a lens layer deposited onto the optical polymer film through a 3D printing technique. The antenna layer may include a transparent antenna embedded into or deposited onto a transparent layer. The lens layer may be 3D printed as multiple partial layers to have a shape that matches a prescription for the lens layer.

Abstract: A corrected optical lens includes an inner layer that includes a low stress optical lens and an outer layer that includes one or more corrective layers. The outer layer may be formed on at least a portion of an outer surface of the inner layer by scanning the outer surface of the inner layer, generating a surface characterization file based on the outer surface scan, and 3D printing the one or more corrective layers on the outer surface of the inner layer based on the surface characterization file as input to a 3D printer. The surface characterization file may be corrected based on a particular predetermined contour of the inner layer prior to being input to the 3D printer. The correction may include, for example, reduction of root mean square (RMS) values of deviations of detected peaks and valleys on the surface of the inner layer.

Abstract: A device is provided. The device includes a reflective polarizer configured to selectively reflect or transmit a polarized light based on a polarization of the polarized light. The device also includes a display element disposed at a first side of the reflective polarizer, and configured to output a first image light representing a virtual image. The device also includes a polarization switch disposed between the display element and the reflective polarizer, and configured to switch or maintain a polarization of the first image light. The device further includes an active dimming device disposed at a second side of the reflective polarizer, and configured to provide an adjustable transmittance of an input light.

Abstract: An optical assembly includes an optically transparent substrate and a first lens removably coupled with the optically transparent substrate by one or more adhesive layers. The one or more adhesive layers are positioned between the optically transparent substrate and the first lens. Also disclosed are an eye-tracker and a display device, each of which includes the optical assembly.

Abstract: A headset for augmented reality applications is provided. The headset includes at least one eyepiece configured to provide a see-through image to a user via a transparent optical component, and to provide an artificial image through a display, and a dimming shutter configured to adjust a transparency level of the transparent optical component. The dimming shutter further includes an active liquid crystal layer configured to adjust a transparency level according to an electrical power provided between two electrodes, and a photoactive layer configured to adjust the transparency level upon absorption of an ultraviolet radiation for a selected period of time. A default orientation of a host material in the active liquid crystal layer may be in a dark state or in a clear state, when no electrical power is provided. A method and a memory storing instructions to execute the method for use of the above device are also provided.

Abstract: A lens includes a glass layer and a plastic layer. The glass layer has a first glass side disposed opposite of a second glass side. The plastic layer has a first plastic side disposed opposite of a second plastic side. The first plastic side of the plastic layer is bonded to the second glass side of the glass layer. The outside plastic boundary of the plastic layer extends past an outside glass boundary of the glass layer.