Abstract: The present invention is related to deuterated secnidazole, a prodrug thereof, a metabolite thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof. The present invention is also related to methods of screening deuterated forms of secnidazole to identify potent and high metabolic lifetime compounds for treating bacterial vaginosis or trichomoniasis.

Abstract: The present invention is related to deuterated secnidazole, a prodrug thereof, a metabolite thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof. The present invention is also related to methods of screening deuterated forms of secnidazole to identify potent and high metabolic lifetime compounds for treating bacterial vaginosis or trichomoniasis.

Abstract: The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.

Abstract: The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.

Abstract: An underwater EM measurement system, which is substantially smaller, much simpler to use, and more robust than prior systems, is formed as a sensor package integrated into a single pressure vessel includes two magnetic sensors including induction coils disposed substantially horizontally so as to measure fields in orthogonal directions. The package also includes two electric field sensors including electric potential antennas adapted to couple to a water potential via a capacitive electrode having a conducting material and an electrically insulative layer formed of an insulating material. The capacitive electrode has a capacitance to the medium of greater than 1 mF. Preferably, the insulating material is a metal oxide.

Abstract: Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof.

Abstract: Currently there is no conventional tool kit/method available to determine the most appropriate drug delivery technology for a drug molecule. Instead, different drug delivery options are investigated through actual experimentation, and the most appropriate drug delivery technology is selected based on trial and error. Embodiments of the current disclosure provide an innovative, unique, versatile, all-inclusive tool kit/method for one or more appropriate delivery technologies to be recommended by a drug-technology company providing those technologies to a customer for a given drug molecule based on the characteristics of a the drug molecule provided as input.

Abstract: Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof.

Abstract: Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof.

Abstract: The present invention discloses a tagging and identification device and system for tracking and monitoring sea vessels as they enter sea ports, estuaries and/or other channels. The tagging device of the present invention comprises a receiver, for receiving an underwater electromagnetic signal transmitted by an underwater beacon. An acoustic transmitter is provided for transmitting an identification signal to an acoustic receiver deployed nearby. The acoustic identification signal is transmitted after an electromagnetic trigger signal is received from the underwater beacon. The tagging and device may further comprise a memory device which can store data relating to position and time of the see vessel to which it is attached. The tagging and identification device of the present invention is covert, compact and is capable of extended active deployment without replenishment of batteries etc.

Abstract: Disclosed herein are deuterium-enriched colchicine, thiocolchicine, and derivatives thereof. The deuterium-enriched compounds are useful as, an antiproliferative agent, a muscle relaxant, an anti-inflammatory agent, or an anti-gout agent.

Abstract: The present invention discloses a tagging and identification device and system for tracking and monitoring sea vessels as they enter sea ports, estuaries and/or other channels. The tagging device of the present invention comprises a receiver, for receiving an underwater electromagnetic signal transmitted by an underwater beacon. An acoustic transmitter is provided for transmitting an identification signal to an acoustic receiver deployed nearby. The acoustic identification signal is transmitted after an electromagnetic trigger signal is received from the underwater beacon. The tagging and device may further comprise a memory device which can store data relating to position and time of the see vessel to which it is attached. The tagging and identification device of the present invention is covert, compact and is capable of extended active deployment without replenishment of batteries etc.

Abstract: Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof.

Abstract: Disclosed herein is a pyrrolopyrazine COMPOUND I having defined amounts of R isomer, particle size, and stability. Also disclosed are pyrrolopyrazine oral dosage forms comprising the described COMPOUND I material as well as methods of treating disorders amenable to therapy using COMPOUND I.

Abstract: According to the invention, there is provided a more heat-resistant laminate comprising a metal foil, a fabric, and bonding means between the metal foil and the fabric, wherein the bonding means are a flouropolymer foil functioning as an adhesive film for bonding the fabric and the metal foil together. Hereby, an impermeable laminate is provided which is flexible and can withstand higher temperatures without delaminating. A laminate according to the invention can be mounted directly against hot components with temperatures up to 550° C. when the fabric is a woven glass fabric and as high as 1100° C. if the fabric is ceramic. The bonding means are stabile in temperatures up to 290° C. and provides a stabile and durable bonding also during temperature exposure of the laminate of 310° C. for an extended period of time.

Abstract: An underwater EM measurement system, which is substantially smaller, much simpler to use, and more robust than prior systems, is formed as a sensor package integrated into a single pressure vessel includes two magnetic sensors including induction coils disposed substantially horizontally so as to measure fields in orthogonal directions. The package also includes two electric field sensors including electric potential antennas adapted to couple to a water potential via a capacitive electrode having a conducting material and an electrically insulative layer formed of an insulating material. The capacitive electrode has a capacitance to the medium of greater than 1 mF. Preferably, the insulating material is a metal oxide.

Abstract: Active agent compositions comprising active agent particles having an effective average particle size of less than 2000 nm, wherein the compositions comprise a particle sequestrant are disclosed. Compositions having an effective average particle size of less than 2000 nm, wherein the compositions comprise no added surfactants, phospholipids, or combinations thereof, are also disclosed. In some embodiments, the active agent is fenofibrate. In other embodiments, the fenofibrate compositions are in a treatment form that that is bioequivalent to TriCor® 145 mg or 48 mg.

Abstract: Disclosed herein are antibiotic formulations and combinations of antibiotic and symptomatic relief agent formulations. The combinations are suitable to treat a variety of diseases, including an infection, while treating the symptoms associated with the disease. Also disclosed are methods of treating a disease or an infection and its symptoms, as well as pharmaceutical kits containing such formulations.