Abstract: An image sensing device includes a substrate extending in a first direction and a second direction and including a first surface and a second surface; a plurality of unit pixel regions supported by the substrate to generate signal carriers through conversion of incident light; a plurality of circuit structures arranged to be spaced apart from each other in the first direction to generate a current in the substrate and capture the signal carriers carried by the current; a first isolation structure disposed between adjacent unit pixel regions in the substrate and extending vertically in a depth direction of the substrate while extending in the second direction; and a plurality of second isolation structures located on two opposite sides of the plurality of circuit structures in the second direction within the substrate, and arranged to extend obliquely in a depth direction in the substrate while extending in the first direction.

Abstract: A method for operating a storage device capable of improving reliability of a memory system is provided. The method includes providing a storage device which includes a first component and a second component; receiving, via a host interface of the storage device, a command for requesting failure possibility information about the storage device from an external device; and providing, via the host interface, the failure possibility information about the storage device to the external device in response to the command.

Abstract: The present invention relates to a hydroxylphenyl-terminated polysiloxane, a polysiloxane-polycarbonate copolymer comprising the same as repeating unit, and a method for preparing the copolymer, and more specifically, a polysiloxane of a specific structure having terminal silane unit comprising optionally substituted hydroxylphenyl group, and a polysiloxane-polycarbonate copolymer which comprises the polysiloxane and a polycarbonate block as repeating units, and thereby shows the same or more excellent transparency and significantly further improved flame retardancy as compared with the level of conventional polysiloxane-polycarbonate copolymer, and a method for preparing the same.

Abstract: Provided are a system and method for diagnosing operational safety of railcars in which one or more vibration sensors installed in each car of a train measure and analyze vibrations generated from the running car, running information including the travel location and travel speed of the car is added to vibration data and transmitted to a central control system, integrated running information is analyzed through pretrained artificial intelligence (AI) to estimate an abnormal part of the cars or railroad, and the AI is retrained through big data analysis.

Abstract: Disclosed are a content box providing method and a user terminal.

Abstract: The present invention relates to an extracellular vesicle expressing a cytokine and an antibody, a method for producing same, and a use thereof. The present invention provides a method for producing an immune cell expressing both a cytokine and an antibody on membrane surface by transforming them with a first vector encoding a cytokine and a second vector encoding an antibody, and producing their extracellular vesicle expressing both a cytokine and an antibody on the surface. The present invention provides the extracellular vesicle which induces a desired cytokine response in cells that can be targeted with a specific antibody and is safe for the human body while exhibiting excellent anticancer effects. The present invention provides a new cancer treatment means that deliver drugs or physiologically active substances to specific cancer cells by loading a drug or physiologically active substance that exhibits a therapeutic effect on cancer in the extracellular vesicle.

Abstract: The present invention relates to a GFRAL-antagonistic antibody having improved affinity and a use thereof, and more particularly, the present invention relates to an anti-GFRAL antibody having improved affinity, comprising a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. The anti-GFRAL antibody having improved affinity exhibits higher binding ability to a GFRAL protein than a conventional anti-GFRAL antibody, and thus is expected to be effectively used for improving or treating cancer-related anorexia or cachexia syndrome and side effects of chemotherapy anticancer drugs.

Abstract: A link shared through a chat room in a chat application is displayed. When a selection of the link is received, a content execution result corresponding to the link through an in-app browser of the chat application or an external browser distinct from the chat application is displayed. A notification for a new chat message is then displayed while the content execution result is being displayed through the in-app browser or the external browser. When a selection for the notification of the new chat message is received, the display of the content execution result is switched to a display of the chat room in which the new chat message was received. A content box, which enables access to the content execution result, is displayed on the switched display of the chat room.

Abstract: A method of controlling an EOP of a powertrain may include determining, by a controller electrically connected to the EOP, whether an oil sloshing phenomenon in which it is difficult for oil to return to a space where an oil intake port of the EOP is positioned may occur while a vehicle is running; and reducing, by the controller, the revolutions per minute (RPM) of the EOP by a predetermined reduced RPM when it is determined that the oil sloshing phenomenon may occur.

Abstract: The present invention relates to a novel anti-C-MPL antibody and a use thereof, and specifically, to an anti-C-MPL antibody having an effect of increasing platelet production and its number through the maturation of megakaryocytes in the bone marrow, and a use thereof. The novel anti-C-MPL antibody (2R13) of the present invention is a polymer material and has a longer half-life than the conventional therapeutic agents, and it has the advantage of low self-antibody production and low immunogenicity as an antibody agent. In addition, it can be used as a therapeutic agent for thrombocytopenia by increasing the platelet level of patients suffering from chronic or complication-induced immune thrombocytopenia.

Abstract: The present invention relates to a method for screening a cytokine having anticancer activity that inhibits the exosome secretion or suppresses the expression of PD-L1, wherein a vector composed of gene encoding cytokine, linker domain, and transmembrane domain transforms into cancer cells, and cytokine exhibiting anticancer activity can be selected, and thus the selected cytokine is provided as a new anticancer agent. In addition, the present invention relates to composition for preventing or treating cancer diseases, the composition comprising IL-15, selected using the above-mentioned screening technique, or expression promoter or activator thereof as an active ingredient. In the present invention, it was found that treating cancer cells with IL-15 suppresses exosome secretion and the expression of PD-L1, and it was also found that the anticancer effect is directly exhibited on the cancer cells. Therefore, IL-15 or expression promoter or activator can be effectively used to prevent or treat cancer diseases.

Abstract: Disclosed are a content box providing method and a user terminal. The method may comprise the steps of: displaying a link shared through a chat room in a chat application; when a selection for the link is received, displaying a screen of a content execution result corresponding to the link through an in-app browser of the chat application or an external browser distinct from the chat application; displaying a notification for a new chat message while the screen of the content execution result is being displayed through the in-app browser or the external browser; when a selection for the notification of the new chat message is received, switching the screen of the content execution result to a screen of the chat room to which the new chat message received; and displaying a content box, which enables access to the content execution result, on the switched screen of the chat room.

Abstract: The present invention relates to a GFRAL-antagonistic antibody and a use thereof, and more particularly, to an anti-GFRAL antibody comprising a heavy chain CDR and a light chain CDR of specific sequences, and an antigen-binding fragment thereof. The anti-GFRAL antibody is expected to be usefully utilized for ameliorating or treating anorexia-cachexia syndrome associated with cancer, and adverse effects of chemotherapeutic drugs.

Abstract: The present invention relates to a polysiloxane-polycarbonate copolymer using a hydroxyl terminated polysiloxane mixture, and a method for producing same, and more specifically, to: a polysiloxane-polycarbonate copolymer which includes hydroxy-terminated polysiloxanes of chemical formulae 1 and 2 in a specific weight ratio as repeating units, and thus exhibits excellent transmittance and low-temperature impact strength compared to the case of using either of the hydroxy-terminated polysiloxanes by itself, and in which the overall production yield of the raw material polysiloxane is improved, such that the polysiloxane-polycarbonate copolymer is excellent in terms of economics; and a method for producing same.

Abstract: A powertrain-cooling system of a hybrid vehicle may include an electric oil pump, a pressure control valve, which includes an input port receiving fluid discharged from the electric oil pump, an output port outputting the fluid to a transmission while adjusting the pressure of the fluid, and a drain port discharging a portion of the fluid in accordance with adjustment of the pressure of the fluid, a first motor cooling path connecting the drain port of the pressure control valve to a first motor forming a hybrid powertrain, and a controller electrically connected to the electric oil pump and configured for controlling the electric oil pump to cool the transmission and the first motor.

Abstract: The method of bonding an interposer and an integrated circuit chip includes preparing an interposer including an insulator and conductive lines each having one end exposed to a first surface of the insulator and another end exposed to a second surface opposite to the first surface; placing a bonding mask on the interposer; forming through-holes on the bonding mask before or after the placing of the bonding mask on the interposer; filling the plurality with a conductive material; and bonding an integrated circuit chip to the bonding mask.

Abstract: A method of controlling an electric oil pump (EOP) of a vehicle includes: confirming a gear shift type when a gear shift of a vehicle is started; compensating for the number of revolutions of the EOP according to the confirmed gear shift type; confirming whether a measured line pressure converges on a command line pressure while the compensating for the number of revolutions of the EOP according to the gear shift type is performed; and, when it is determined that the measured line pressure does not converge on the command line pressure, additionally compensating for the number of revolutions of the EOP.

Abstract: A method of controlling an EOP of a hybrid vehicle may include controlling the EOP in a predetermined high-speed mode when the vehicle is started; controlling the EOP in a predetermined middle-speed mode in which the EOP is driven at revolutions per minute (RPM) lower than RPM of the high-speed mode when the high-speed mode is terminated; and controlling the EOP in a predetermined low-speed mode in which the EOP is driven at RPM lower than the RPM of the middle-speed mode when the vehicle is stopped.

Abstract: A method for controlling an electric oil pump (EOP) of a hybrid vehicle may include determining whether or not the hybrid vehicle is in a decelerating situation in an EV mode, driving the EOP at an RPM at a point L, corresponding to a minimum RPM of the EOP to form a target line pressure of a transmission, upon determining that the hybrid vehicle is decelerating in the EV mode, determining whether or not an RPM of a turbine is equal to or greater than a predetermined reference RPM, and driving the EOP at an RPM acquired by adding a predetermined additional RPM to secure an additional flow rate of automatic transmission fluid supplied to a balance chamber of an engine clutch to the RPM at the point L, upon determining that the RPM of the turbine is equal to or greater than the predetermined reference RPM.

Abstract: Polycarbonate block copolymers are provided, which have: (A) a polyester block of chemical formula 1; and (B) a polycarbonate block derived from a dihydric phenol of chemical formula 3 compound and phosgene. The copolymers may be prepared by (1) polymerizing ester oligomers to form a compound of chemical formula 1; and (2) copolymerizing the ester oligomer obtained in (1) with a polycarbonate oligomer prepared from a dihydric phenol compound of chemical formula 3 and phosgene, in the presence of a polymerization catalyst. The block copolymer may have a viscosity average molecular weight (Mv) of 10,000 to 200,000.