Abstract: The present disclosure provides autotaxin (ATX) inhibitor compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for inhibiting ATX. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Abstract: Provided is a method for prevention or treatment of a lysosomal storage disorder, and more particularly, to a method that may exhibit excellent efficacy against various lysosomal storage disorders including Niemann-Pick disease by including graphene quantum dots.

Abstract: The present invention relates to a donepezil eutectic mixture and a use thereof. A eutectic mixture of the present invention allows increased solubility and skin permeability of donepezil, and a pharmaceutical composition including the same does not generate donepezil crystals and maintains amorphous form even when stored under various conditions, thereby being applicable to various formulations while also having excellent stability and efficacy.

Abstract: The present invention relates to a system and a method for determining a stroke based on a voice analysis. According to the present invention, voice data of subjects are collected to extract and analyze voice onset times to determine stroke patients based on voices. The system for determining a stroke generates and collects voice data from test subjects reading a predetermined word that includes a plosive sound. The system for determining a stroke extracts and calculates voice onset times from the voice data to calculate probability parameters for the voice onset times of each of a normal group and a stroke patient group. The system for determining a stroke uses a set of probability parameters to determine an integration section, and calculates probabilities of being in the normal group and the stroke patient group. The system for determining a stroke applies the calculated probabilities to the Bayes theorem to determine whether the subjects are stroke patients.

Abstract: An apparatus and method for sensing body information is provided. The apparatus includes: a light-emitting device configured to emit a light signal toward an object that is to be sensed; a light-receiving device configured to detect a reflected light signal reflected from the object; an image sensor configured to detect the reflected light signal reflected from the object; and a controller configured to selectively drive at least one of the light-receiving device and the image sensor according to a distance between the object and the light-emitting device and to sense volume information or blood flow information of the object by using the reflected light signal.

Abstract: A cooking appliance having an improved structure capable of improving visibility to enable a user to clearly look at the inside of the cooking chamber during cooking includes a main body having the cooking chamber and a door disposed at the main chamber to open or close the cooking chamber, the door including a shielding member woven with conductive wires and a fixing member to electrically connect the shielding member with a door frame of the door. Electromagnetic waves generated in the cooking chamber can be prevented from leaking to the outside.

Abstract: A control method for preventing an unnecessary control command from being transmitted to a reception Internet of things (IoT) device in an IoT system, and an electronic device thereof are provided. The control method includes receiving first access control information generated from an external electronic device and storing the first access control information, in response to occurrence of an event for transmitting a first control command to the external electronic device, determining whether the first control command has an authority to control the external electronic device using the first access control information, and, in response to a determination that the first control command has the authority to control the external electronic device, transmitting the first control command to the external electronic device.

Abstract: The present disclosure relates to a differentiation totipotent stem cell having suppressed immune rejection, by having expression of Beta-2 microglobulin (B2M) gene suppressed, and expressing Cluster of Differentiation 24 (CD24), immune cell, and pharmaceutical composition including the same.

Abstract: Provided are a method of preparing induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), both having a reduced expression level of HLA, which is a cause of immune rejection upon transplantation of cells, tissues, or organs, a method of preparing mesenchynmal stem cells (MSCs) by using a novel differentiation method of iPSCs, and a cell therapy product using the iPSCs, ESCs, and/or MSCs. The HLA gene-deleted MSCs prepared in the present invention may be used to prepare various types of cells that do not cause immune rejection, and may be used for therapeutic purposes in the future.

Abstract: The present invention provides methods for treating or ameliorating metabolic diseases, cholestatic liver diseases, or organ fibrosis, which comprises administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising an isoxazole derivative, a racemate, an enantiomer, or a diastereoisomer thereof, or a pharmaceutically acceptable salt of the derivative, the racemate, the enantiomer, or the diastereoisomer.

Abstract: The present invention relates to isoxazole derivatives, including pharmaceutical compositions and for the preparation of isoxazole derivatives. And more particularly the present invention provided a pharmaceutical composition of isoxazole derivatives for activation of Farnesoid X receptor (FXR, NR1H4).

Abstract: Provided is a lunch box container including a lower housing that is formed to have an inner containing space; an upper housing that is hinged to one edge of the lower housing and is rotatable; an inner case contained in the lower housing and provided with partition walls to separate a plurality of inner spaces; and a locking wing that is formed on the other edge of the lower housing or the upper housing. The upper housing includes a trench portion formed on a lower surface to correspond to an upper end portion of the inner case.

Abstract: The present invention relates to an anti-inflammatory composition comprising a graphene nano-structure as an active ingredient. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating an inflammatory disease, and a cosmetic composition or feed composition for preventing or improving an inflammatory disease, which include the anti-inflammatory composition, and a method of treating an inflammatory disease, including administering the composition to a subject in need thereof.

Abstract: A bilayer combination tablet for oral administration, which is prescribed for alleviation of symptoms or signs of osteoarthritis (degenerative arthritis), alleviation of symptoms or sings of rheumatoid arthritis, alleviation of symptoms or signs of ankylosing spondylitis, alleviation of acute pain in adults (post-operative or post-tooth extraction pain), alleviation of primary dysmenorrhea, or alleviation of severe and moderate acute or chronic pain. The bilayer combination tablet includes: a controlled-release layer containing tramadol as an active ingredient; and an immediate-release layer containing celecoxib as an active ingredient. A composition for treating pain may be provided, which has a long-lasting analgesic effect for 12 hours while reducing the side effects of tramadol by slow release of water-soluble tramadol and immediate release of poorly soluble celecoxib.

Abstract: A temperature controller of a plasma-processing apparatus including a heating unit and a cooling unit. The heating unit is configured to heat a liner on an inner surface of a plasma chamber in which a plasma is formed. The cooling unit is configured to cool the liner to controls a temperature of an upper electrode in the plasma chamber.

Abstract: Disclosed is a server for performing authentication or identification using biometric information including basic information and detailed information includes a storage for storing basic information and detailed information that are separately encrypted for each of a plurality of users, a communicator for communicating with an external device, and a processor configured to, based on separately encrypted basic information and detailed information being received from an external terminal device through the communicator, performing user authentication or user identification for the received basic information and detailed information by decrypting and comparing the stored encrypted basic information and the received encrypted basic information, and comparing the received detailed information with at least one piece of stored detailed information corresponding to a piece of basic information having a degree of similarity that is higher than or equal to a predetermined value and with the received basic information

Abstract: A semiconductor substrate manufacturing method according to an embodiment comprises the steps of: contaminating at least one of a surface layer of a doped semiconductor substrate having a specific resistance of less than 0.1 ?·cm and a bulk layer below the surface layer with at least one metal of Fe, Cu, and Ni; performing dry oxidation at 950° C. for 30 minutes to forcibly form an oxide film on the surface of the semiconductor substrate; and assessing at least one of the presence and the degree of contamination of metal contained in at least one of the oxide film-formed surface layer and bulk layer by using a photoluminescence assessment method.

Abstract: Provided are a similarity-based question recommendation method and server, and more particularly, to a similarity-based question recommendation method and server which recommend questions between highly similar students by analyzing the similarity between students. A similarity-based question recommendation method performed by a computing device, the method including: forming a point indicating a first student and a point indicating a second student in a first Euclidean space, comparing a student reference distance with a student absolute distance and recommending content related to the second student to a terminal of the first student if the student absolute distance is equal to or less than the student reference distance, wherein the first Euclidean space is comprised of a plurality of axes corresponding to one or more questions, respectively.

Abstract: According to one embodiment of the present disclosure, the head cradle including 5 two head band members fastened to each other is provided, where the head band member includes: a support member extending in one direction; a first fastening part formed at one end portion of the support member and having an insertion hole formed to pass therethrough; a second fastening part formed at the other end portion of the support member; and a strap connection part which is formed at an end portion of the first 0 fastening part or the second fastening part and to which a strap connected to a mask main body is connected, where the support member includes a hole-section on which at least one slit hole having a shape extending at a predetermined angle with respect to the one direction is formed.

Abstract: An electrostatic chuck assembly includes a dielectric plate having an absorption electrode to generate an electrostatic force, the dielectric plate securing a substrate by the electrostatic force, a conductive base plate under the dielectric plate to be applied with a high frequency electric power, the conductive base plate being an electrode to generate plasma, and an insulating plate under the base plate, the insulating plate having an insulation body and an insulation sink, and the insulation sink having a dielectric constant lower than that of the insulation body.