Abstract: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

Abstract: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.

Abstract: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

Abstract: This disclosure provides systems, methods and apparatus for providing illumination by using a light guide to distribute light and for determining spacing between light turning features in the light guide. In one aspect, a light intensity profile along a first axis is determined and the pitch of light turning features along that first axis is varied based upon this profile, while the pitch along a second crossing axis (for example, an orthogonal axis) and the sizes of the light turning features remain unchanged. In some implementations, an apparatus includes a light guide having an array of light turning features configured to turn light from at least one light emitter. The light turning features can be non-uniformly spaced apart along a first axis such that pitches vary non-monotonically and, along a second axis that crosses the first axis, the light turning features are spaced apart with substantially the same progression.

Abstract: This disclosure provides systems, methods and apparatus for providing illumination by using a light guide to distribute light. In one aspect, the light guide has a light input edge into which light is injected and transverse edges transverse to the light input edge. The transverse edges are smooth and act as specular reflectors. The light input edge is rough and provides a diffusive interface. The light emitters are adjacent and centered along the light input edge, with the pitch of the light emitters being about ?L, where ?L is the distance between the transverse edges divided by the number of light emitters. The light guide can be provided with light turning features that redirect light out of the light guide. In some implementations, the redirected light can be applied to illuminate a display.

Abstract: This disclosure provides systems, methods and apparatus for providing illumination by using a light guide to distribute light. In one aspect, the light guide has a surface, such as an edge, into which light is injected. The surface is treated to create a diffusive interface with a light source. For example, the surface may be subjected to abrasion to form a frosted surface that acts as the diffusive interface, or a diffusive structure may be attached to the edge, with the attached diffusive structure functioning as the diffusive interface. The diffusive interface diffuses light entering into the light guide, and can thereby increase the uniformity of light propagating within the light guide. The light guide may be provided with light turning features that redirect light out of the light guide. In some implementations, the redirected light may be applied to illuminate a display.

Abstract: In various embodiments described herein, a display device includes a front illumination device that comprises a light guide disposed forward of an array of display elements, such as an array of interferometric modulators, to distribute light across the array of display elements. The light guide may include a turning film to deliver uniform illumination from a light source to the array of display elements. For many portable display applications, the light guide comprises the substrate used in fabricating the display elements. The display device may include additional films as well. The light guide, for example, may include a diffuser and/or an optical isolation layer to further enhance the optical characteristics of the display.

Abstract: Various embodiments of the present invention relate to enhancing the brightness of displays that employ illumination systems. In some embodiments, the illumination systems include light guides, diffractive microstructure, and light-turning features. The diffractive microstructure may be configured to receive ambient light at a first angle and produce diffracted light at a second angle greater than the first angle and greater than the critical angle for of light guide. The light is thereby guided within the light guide. The light-turning features may be configured to turn the light guided within the light guide out of a light guide and onto, for example, a spatial light modulator at near normal incidence.

Abstract: In various embodiments described herein, a display device includes a front illumination device that comprises a light guide disposed forward of an array of display elements, such as an array of interferometric modulators, to distribute light across the array of display elements. The light guide may include a turning film to deliver uniform illumination from a light source to the array of display elements. For many portable display applications, the light guide comprises the substrate used in fabricating the display elements. The display device may include additional films as well. The light guide, for example, may include a diffuser and/or an optical isolation layer to further enhance the optical characteristics of the display.

Abstract: Various embodiments of the present invention relate to enhancing the brightness of displays that employ illumination systems. In some embodiments, the illumination systems include light guides, diffractive microstructure, and light-turning features. The diffractive microstructure may be configured to receive ambient light at a first angle and produce diffracted light at a second angle greater than the first angle and greater than the critical angle for of light guide. The light is thereby guided within the light guide. The light-turning features may be configured to turn the light guided within the light guide out of a light guide and onto, for example, a spatial light modulator at near normal incidence.

Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

Abstract: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

Abstract: An edge bar having features that discriminate between light propagating in one direction versus the opposite direction may be configured so as to couple light into a light guide while significantly mitigating against edge shadow artifact.

Abstract: One embodiment of the communication system includes a switch, at least one base station, and a backhaul connection including at least one wireless link connecting the at least one base station to the switch. The wireless link may include at least one of a WiMax carrier and a WiFi carrier.

Abstract: A circuit board carrier has main frame, at least one first holder, at least one slide and at least one second holder. The first and second holders are mounted on and selectively slide on the main frame. The slide is mounted on and selectively slides on the corresponding first holder. The slide has a first pin and the second holder has a second pin. The circuit board is held on the circuit board carrier by the pins. Therefore, the circuit board is kept from being contacted to the delivering wheels during manufacturing and is not polluted and trapped by the delivering wheels.

Abstract: Various embodiments disclose an illumination apparatus. The apparatus may comprise a light guide supporting propagation of light and having at least a portion of one of its edges comprising an array of microstructures. These microstructures may be incorporated in the input window of the light guide to control the light intensity distributed within the light guide. In certain embodiments, the directional intensity of the light entering the light guide may be modified to achieve a desired distribution across the light guide.

Abstract: The invention provides a method for determining sensitivity of a cell population to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, which method comprises assaying for an epigenetic modification at the TNF? locus in the cell population as compared to the TNF? locus in a cell population not sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, wherein the presence of the epigenetic modification indicates that the cell population is sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs.

Abstract: Systems and methods for illuminating interferometric modulator reflective displays are disclosed. One embodiment includes a display including a plurality of interferometric modulators configured to reflect a spectrum of radiation having a reflectance response peak at one or more wavelengths. A plurality of quantum dots are configured to emit radiation having a peak wavelength substantially at said one or more wavelengths, and the display is configured such that light emitted from the quantum dots irradiates the plurality of interferometric modulators.

Abstract: A circuit board carrier has main frame, at least one first holder, at least one slide and at least one second holder. The first and second holders are mounted on and selectively slide on the main frame. The slide is mounted on and selectively slides on the corresponding first holder. The slide has a first pin and the second holder has a second pin. The circuit board is held on the circuit board carrier by the pins. Therefore, the circuit board is kept from being contacted to the delivering wheels during manufacturing and is not polluted and trapped by the delivering wheels.

Abstract: The invention relates to the isolation and use of hematopoietic and embryonic stem cells. Additionally, the inventors identified the peritoneal cavity as a new source of hematopoietic stem cells. In one embodiment, the invention provides methods of isolating progenitor and/or stem cells from the peritoneal cavity. In another embodiment, the invention provides methods of transporting progenitor and/or stem cells from the peritoneal cavity to another organ. In another embodiment, the present invention provides methods of regenerating bioengineered tissues and/or reconstituting an hematopoietic system.