Patents by Inventor Lakshman R. Sehgal

Lakshman R. Sehgal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Patent number: 7713522
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a gutless adenovirus vector carrying a transgene, such as a gene encoding TM protein or its variant.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: May 11, 2010
    Assignee: BioVec, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Patent number: 7687058
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a gutless adenovirus vector carrying a transgene, such as a gene encoding TM protein or its variant.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: March 30, 2010
    Assignee: BioVec, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Patent number: 7670597
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: March 2, 2010
    Assignee: Biovec, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Composition for Preserving Platelets and Method of Using the Same
    Publication number: 20090263781
    Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
    Type: Application
    Filed: May 8, 2009
    Publication date: October 22, 2009
    Applicant: BIOVEC, LLC.
    Inventors: Lakshman R. Sehgal, Shaker Mousa
  • COMPOSITION FOR PRESERVING PLATELETS AND METHOD OF USING THE SAME
    Publication number: 20090253115
    Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
    Type: Application
    Filed: May 11, 2009
    Publication date: October 8, 2009
    Applicant: BIOVEC, LLC.
    Inventors: Lakshman R. SEHGAL, Shaker Mousa
  • In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
    Publication number: 20090238795
    Abstract: A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
    Type: Application
    Filed: January 26, 2009
    Publication date: September 24, 2009
    Applicant: BIOVEC, LLC.
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Publication number: 20090123440
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a gutless adenovirus vector carrying a transgene, such as a gene encoding TM protein or its variant.
    Type: Application
    Filed: July 28, 2008
    Publication date: May 14, 2009
    Applicant: BIOVEC, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Publication number: 20090105180
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a gutless adenovirus vector carrying a transgene, such as a gene encoding TM protein or its variant.
    Type: Application
    Filed: July 28, 2008
    Publication date: April 23, 2009
    Applicant: BIOVEC, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Patent number: 7501114
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel in vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: March 10, 2009
    Assignee: Biovec, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Patent number: 7481998
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a gutless adenovirus vector carrying a transgene, such as a gene encoding TM protein or its variant.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: January 27, 2009
    Assignee: BioVec, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • COMPOSITION FOR PRESERVING PLATELETS AND METHOD OF USING THE SAME
    Publication number: 20080233554
    Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
    Type: Application
    Filed: April 25, 2008
    Publication date: September 25, 2008
    Applicant: BIOVEC, LLC
    Inventors: Lakshman R. Sehgal, Shaker Mousa
  • and expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Patent number: 7179459
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: February 20, 2007
    Assignee: Biovec, LLC
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Acellular red blood cell substitute
    Patent number: 6914127
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: July 5, 2005
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
    Publication number: 20040198683
    Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
    Type: Application
    Filed: December 2, 2003
    Publication date: October 7, 2004
    Inventors: Lakshman R. Sehgal, Jonathan Wong
  • Acellular red blood cell substitute
    Publication number: 20030130487
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Application
    Filed: January 21, 2003
    Publication date: July 10, 2003
    Applicant: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. DeWoskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Acellular red blood cell substitute
    Patent number: 6552173
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: April 22, 2003
    Assignee: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Acellular red blood cell substitute
    Publication number: 20020062007
    Abstract: An a cellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said a cellular red blood cell substitute.
    Type: Application
    Filed: November 27, 2001
    Publication date: May 23, 2002
    Applicant: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. DeWoskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Acellular red blood cell substitute
    Patent number: 6323320
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: November 27, 2001
    Assignee: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Acellular red blood cell substitute
    Patent number: 6133425
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: March 15, 1993
    Date of Patent: October 17, 2000
    Assignee: Northfield Laboratories, Inc
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Acellular red blood cell substitute
    Patent number: 5747649
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 5, 1998
    Assignee: Norhtfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal