Patents by Inventor Lakshman R. Sehgal

Lakshman R. Sehgal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acellular red blood cell substitute
    Patent number: 5464814
    Abstract: A process is disclosed for the preparation of an essentially tetramer-free, essentially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin which comprises separating red blood cell stroma from blood by means of heat treating step to remove stromal contaminants and filtration or centrifugation or both, pyridoxylating, polymerizing, and removing essentially all of the remaining unmodified tetramer.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: November 7, 1995
    Assignee: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Oxygen carrying multiple emulsions
    Patent number: 5438041
    Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: August 1, 1995
    Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.
    Inventors: Shuming Zheng, Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen
  • Process for preparation of hemoglobin multiple emulsions
    Patent number: 5217648
    Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.
    Type: Grant
    Filed: October 11, 1991
    Date of Patent: June 8, 1993
    Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.
    Inventors: Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen
  • Acellular red blood cell substitute
    Patent number: 5194590
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its uses and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: November 21, 1990
    Date of Patent: March 16, 1993
    Assignee: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
  • Acellular red blood cell substitute
    Patent number: 4826811
    Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: May 2, 1989
    Assignee: Northfield Laboratories, Inc.
    Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal