Abstract: A prosthetic heart valve includes a first upper frame portion and a stent frame connected to the first upper frame portion via at least two stent frame extensions. The stent frame includes a base and at least two stent posts extending upwardly from the base towards the first upper frame portion. The first upper frame portion, the base, and the at least two stent posts each has an inner surface and an outer surface. The prosthetic heart valve also includes at least one sheet of leaflet material configured to encircle the stent frame and weave through the stent frame between the first upper frame portion and the base.

Abstract: A computer implemented method includes retrieving data from a patient's updated electronic medical record relevant to a diagnosis of a disease. The data includes medical images and at least one of the patient's demographic data, morbid symptoms, vital signs, medications, surgery history, family medical history, genetic data, laboratory test data, diseases records, allergies, and medical insurance information. The method includes generating available treatment path options including at least one surgical treatment or intervention, using at least one model to predict at least one implication for each of the available treatment path options based on the data and simulated adverse outcomes of the at least one surgical treatment or intervention simulated by predictive models including a biomechanical model based on the medical images. The method includes interactively updating and displaying a decision tree including the available treatment path options each with a corresponding at least one objective function.

Abstract: A vehicle body including a side sill having a side sill inner panel, a side sill outer panel, and a unitary side sill reinforcement panel located between the side sill inner panel and the side sill outer panel. The side sill reinforcement panel includes a first wall portion coupled to the side sill outer panel, a second wall portion extending from the first wall portion away from the side sill outer panel toward the side sill inner panel, a third wall portion extending from the first wall portion away from the side sill outer panel toward the side sill inner panel, a fourth wall portion extending from the third wall portion, a first flange extending from the second wall portion and coupled to the side sill inner panel, and a second flange extending from the fourth wall portion and coupled to the side sill inner panel.

Abstract: Placeholders are inserted and replaced in placeholders in code included in resources. A proxy receives a request for a resource from a client and verifies an authentication credential included therein. The proxy determines a placeholder value indicating the authentication credential is verified and determines the requested resource corresponds to a first modified version of the resource stored in memory accessible to the proxy, the first modified version comprising a code component including a placeholder inserted by the proxy. The proxy replaces the placeholder with a first placeholder value to generate a second modified version of the resource and transmits the second modified version of the resource to a client. In another aspect, a client-side proxy service detects events in a modified version of a web page, inserts a placeholder in code of the web page, replaces the placeholder with a placeholder value, and evaluates the modified code.

Abstract: A computer implemented method for prescribing optimized medical interventions includes retrieving a patient's updated electronic medical record (EMR) and mapping the diagnosis of the patient to a medical treatment database to select a plurality of likely medical intervention choices based on a score exceeding a defined threshold score. The method includes determining a rank order of the selected plurality of medical intervention choices by comparing simulation outcomes for each choice executed by the medical predictive algorithm, on respective choices among each of the selected likely medical interventions. The method also includes receiving by the patient's physician or patient's electronic medical record database, a rank order of recommended medical intervention choices including possible options and associated metrics based on an accepted level of simulated outcome.

Abstract: A computer-implemented method for predicting risk of ischemia in anomalous aortic origin of a coronary artery (AAOCA) includes receiving medical imaging data of a patient. The method includes extracting, from the medical imaging data, patient-specific morphological imaging biomarkers pertaining to AAOCA and incorporating the biomarkers into a computer model. The method includes simulating, using the computer model, hemodynamics of the patient under simulated stress conditions and a combination of variables, the variables comprising physiological properties of the patient. The method also includes predicting and outputting a patient-specific risk profile of ischemia and/or sudden cardiac death based on simulated hemodynamics.

Abstract: A transcatheter prosthetic heart valve includes a stent frame and at least one sheet of leaflet material formed in to a tube, which includes a lower portion disposed on an exterior of the stent frame and an upper edge portion disposed within the stent frame. The upper edge portion includes at least a portion configured to wrap around a first portion of the top edge of the stent frame and fold towards an exterior of the stent frame. The upper edge portion also includes at least another portion configured to weave through the stent frame and fold towards the interior of the stent frame.

Abstract: In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging of a heart valve in a pre-operative state. The method includes generating a segmented heart valve by segmenting the heart valve of the 3D imaging. The method includes simulating a surgical procedure on the parameterized heart valve. The method includes determining at least one post-operative outcome based on simulating the surgical procedure on the parameterized heart valve. Systems and machine-readable media are also provided.

Abstract: Placeholders are inserted and replaced in placeholders in code included in resources. A proxy receives a request for a resource from a client and verifies an authentication credential included therein. The proxy determines a placeholder value indicating the authentication credential is verified and determines the requested resource corresponds to a first modified version of the resource stored in memory accessible to the proxy, the first modified version comprising a code component including a placeholder inserted by the proxy. The proxy replaces the placeholder with a first placeholder value to generate a second modified version of the resource and transmits the second modified version of the resource to a client. In another aspect, a client-side proxy service detects events in a modified version of a web page, inserts a placeholder in code of the web page, replaces the placeholder with a placeholder value, and evaluates the modified code.

Abstract: A predictive model for classification of tissue rupture risk is generated by providing a computer aided design (CAD) model suitable for simulating a balloon expandable transcatheter heart valve, and computing stress, strain, and/or displacement at the tissue as a function of expansion of the expandable transcatheter heart valve. The computed stress, strain, and/or displacement at the tissue enables determination of low, moderate or high tissue rupture risk as a function of the expansion at time of the expandable transcatheter heart valve deployment into a patient.

Abstract: A heart valve model includes a parametric leaflet model representing geometries of a heart valve constructed based on at least one landmark point associated with the heart valve. The heart valve model includes a ray casted anatomical structure constructed based on an automatic aortic root reconstruction algorithm to extract a shape of an aorta. The heart valve also includes an additional anatomical structure, wherein the parametric leaflet model, the ray casted anatomical structure, and the additional anatomical structure are combined to obtain the heart valve model.

Abstract: A passive implantable medical device for controlling a flow of fluid through a tube within a patient includes a first component and a second component movably coupled to one another and defining a central passage configured for receiving a portion of the tube therethrough. The passive implantable medical device is configured for moving between a first configuration and a second configuration to constrict a portion of the tube. An active implantable medical device for controlling a flow of a first fluid through a tubing includes a flow control cuff comprising a stiff outer wall and a deformable inner wall which defines a central opening sized such that the tubing can extend therethrough. A pump is configured to modulate a pressure of the second fluid within the interior space to apply a constrictive force to a section of the tubing.

Abstract: A model of an in vivo heart valve device implanted in a patient is generated by providing a known model of a pre-implantation heart valve device, performing an imaging scan on the patient having an implanted heart valve device to obtain at least one patient specific landmark, deforming the known model to fit the at least one patient specific landmark to obtain a constructed patient-specific valve model, and simulating a valve leaflet and skirt for the constructed patient-specific valve model by finite element analysis. The constructed patient-specific valve model accurately represents geometries of the implanted heart valve device in its current in vivo form with an error less than 0.5 mm.

Abstract: In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging. The method includes generating 3D models based on the 3D imaging. The method includes generating, responsive to a pre-determined set of surgical steps, a finite number of 4D time deformation scenes for each pre-determined surgical step associated with the 3D models. The method includes displaying selectively interactive simulations based on the finite number of 4D time deformation scenes. Systems and machine-readable media are also provided.

Abstract: In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging. The method includes generating 3D models based on the 3D imaging. The method includes generating, responsive to a pre-determined set of surgical steps, a finite number of 4D time deformation scenes for each pre-determined surgical step associated with the 3D models. The method includes displaying selectively interactive simulations based on the finite number of 4D time deformation scenes. Systems and machine-readable media are also provided.

Abstract: In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging. The method includes generating 3D models based on the 3D imaging. The method includes generating, responsive to a pre-determined set of surgical steps, a finite number of 4D time deformation scenes for each pre-determined surgical step associated with the 3D models. The method includes displaying selectively interactive simulations based on the finite number of 4D time deformation scenes. Systems and machine-readable media are also provided.

Abstract: A computer implemented method to automatically measure structural features of anatomies using an automatic measurement system, the method includes receiving medical images of the anatomies. The method includes detecting landmarks of the anatomies based on the medical images using an artificial intelligence (AI)-based model and constructing an anatomical structural model of the anatomies based on the detected landmarks. The method includes making quantifying measurements of selected structural features of the anatomical structural model and generating a report including the quantifying measurements.

Abstract: A prosthetic heart valve includes a first upper frame portion and a stent frame connected to the first upper frame portion via at least two stent frame extensions. The stent frame includes a base and at least two stent posts extending upwardly from the base towards the first upper frame portion. The first upper frame portion, the base, and the at least two stent posts each has an inner surface and an outer surface. The prosthetic heart valve also includes at least one sheet of leaflet material configured to encircle the stent frame and weave through the stent frame between the first upper frame portion and the base.

Abstract: A method includes receiving code for computer programming, analyzing the code and extracting a plurality of configuration properties from the code. In the method, one or more configuration files are generated from the extracted plurality of configuration properties, and microservice code is generated from the one or more configuration files. The microservice code is configured for deployment on one or more cloud computing platforms.

Abstract: Embodiments herein disclose systems, methods, and computer-readable media for integrating facial recognition technology into clinical workflows. An application can manage receipt of a source image, including a face of an unidentified individual, and communicate the source image for facial recognition processing. The facial recognition processing can identify an individual and demographic information associated thereto, as well as provide information to access an electronic health record server housing one or more electronic health records. The application can access health-related data for the individual from the individual's EHR and rank the accessed information to communicate to a source device in a custom, prioritized communication.