Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates to a multifunctional therapeutic biological material and preparation method thereof. The process steps of the preparation method are as follows: (1) preparing various three-dimensional micro/nano composite structure on the surface of a biomedical material by using femtosecond laser double pulses; (2) further preparing a nano-flower structure on the three-dimensional micro/nano composite structure by using hydrothermal synthesis method to construct a heterogeneous structure consisting of the three-dimensional micro/nano composite structure and the nano-flower structure; (3) putting the prepared heterogeneous structure into a mixed solution containing gold ions and platinum ions, and by using ultraviolet light reduction method, reducing in situ into gold-platinum bimetallic nanoparticles on the heterogeneous structure to obtain the multifunctional therapeutic biological material.

Abstract: The present invention relates to a method for processing cells or cell nuclei to generate a pool of nucleic acid fragments and using the generated nucleic acid fragments to produce labeled nucleic acid molecules, construct nucleic acid libraries for transcriptome sequencing, or perform high-throughput sequencing of single-cell transcriptomes. Additionally, the invention encompasses the nucleic acid libraries constructed using the described method and the kits used for implementing the disclosed methods.

Abstract: A collection device includes an acquisition device, a control device, and a detection device. The acquisition device acquires information inside a space of a target region. The control device sets a detection path for a collection device based on an unreachable region within the space of the target region. The detection device acquires environmental data including environmental data of the unreachable region detected when the collection device moves along the detection path in the space of the target region.

Abstract: The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: A part identification method includes acquiring an image including a part, detecting the image based on a detection model and identifying a type of the part, and determining part information based on the type of the part identified and outputting the part information. The determining the part information based on the type of the part identified includes determining a part in a predetermined region in the image based on the type of the part identified, and determining the part information based on the part determined. The predetermined region includes a planar region or a spatial region.

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure relates generally to compounds, of Formula I Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof. Methods associated with the preparation and use of the disclosed compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed.

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: A biochar is produced by co-pyrolysing an aquatic plant enriched with heavy metals with a clay mineral, and the aquatic plants themselves have high enrichment and adsorb heavy metals in contaminated water; heavy metals are in situ adsorbed, and are coated or enriched in the biochar, therefore extending the migration time of heavy metals, which are also very stable; attapulgite and montmorillonite as clay minerals are loaded in the biochar during the preparing process; heavy metals contained in the biochar play a catalytic role, and synergy with activated attapulgite, therefore increasing the reliability of the biochar, and effectively reducing the ecological effectiveness and potential risk of heavy metals in the biochar.

Abstract: A construction inspection method includes establishing a first construction model based on detection data at a construction site, comparing the first construction model with a previously established second construction model based on construction design data to acquire a comparison result, confirming an inspection result of a construction in accordance with the comparison result, and sharing the inspection result with a user. A construction inspection apparatus includes a modeling unit that establishes a first construction model based on detection data at a construction site, a comparison unit that compares the first construction model with a previously established second construction model based on construction design data to acquire a comparison result, a confirmation unit that confirms an inspection result of a construction in accordance with the comparison result, and a sharing unit that shares the inspection result with a user.

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSW).

Abstract: The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?1 integrin inhibitors that are useful for treating tissue specific fibrosis.

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates generally to compounds, of Formula I Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.