Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: The present disclosure relates generally to compounds, of Formula I. Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: Provided is a femtosecond laser system for processing a micro-hole array, comprising: a femtosecond laser, a half-wave plate, a polarizer, a concave lens, a convex lens, a diaphragm, a mechanical shutter, a phase-type spatial light modulator, a first plano-convex lens, a reflecting mirror, a second plano-convex lens, a dichroic mirror, a camera, a processing objective lens, a six-axis translation stage and a transmissive white light source.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A public event administrating system is disclosed. The public event involves a plurality of individuals and the administrating system includes: a data collecting module, a data processing module, a medical resource scheduling module, and a grid administrating module. The data collecting module is configured to acquire initial data about the public event from a plurality of data sources. The data processing module is configured to process the initial data to acquire processed data. The medical resource scheduling module is configured to receive an individual service request and allocate currently available medical resources to an individual requesting service at least according to the individual service request. And, the grid administrating module is configured to divide a geographic region managed by the administrating system into a plurality of grids, and assign a plurality of grid administrators to the plurality of grids to respectively administrate individuals in the plurality of grids.

Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates to a multifunctional therapeutic biological material and preparation method thereof. The process steps of the preparation method are as follows: (1) preparing various three-dimensional micro/nano composite structure on the surface of a biomedical material by using femtosecond laser double pulses; (2) further preparing a nano-flower structure on the three-dimensional micro/nano composite structure by using hydrothermal synthesis method to construct a heterogeneous structure consisting of the three-dimensional micro/nano composite structure and the nano-flower structure; (3) putting the prepared heterogeneous structure into a mixed solution containing gold ions and platinum ions, and by using ultraviolet light reduction method, reducing in situ into gold-platinum bimetallic nanoparticles on the heterogeneous structure to obtain the multifunctional therapeutic biological material.

Abstract: The present invention relates to a method for processing cells or cell nuclei to generate a pool of nucleic acid fragments and using the generated nucleic acid fragments to produce labeled nucleic acid molecules, construct nucleic acid libraries for transcriptome sequencing, or perform high-throughput sequencing of single-cell transcriptomes. Additionally, the invention encompasses the nucleic acid libraries constructed using the described method and the kits used for implementing the disclosed methods.

Abstract: A collection device includes an acquisition device, a control device, and a detection device. The acquisition device acquires information inside a space of a target region. The control device sets a detection path for a collection device based on an unreachable region within the space of the target region. The detection device acquires environmental data including environmental data of the unreachable region detected when the collection device moves along the detection path in the space of the target region.

Abstract: The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.