Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A fully-automatic transplanting combined machine includes a traction apparatus, operation apparatus and a control system. The operation apparatus is mounted on the traction apparatus with a main body frame and is towed behind the traction apparatus. The operation apparatus includes a rotary tillage furrowing system, a system for slightly preparing soil and opening narrow furrows, a planting system, and a soil covering compacting system which are arranged successively from front to back. The planting system includes more than one planting unit. The fully-automatic transplanting combined machine is capable of orderly performing rotary tillage, cleaning stubble, leveling a border check, opening a furrow, cutting narrow slits, transplanting, covering soil, compacting soil in untilled soil at one process, so as to create the soil requirements for high-speed transplanting of blanket seedlings such as rape and other crops.

Abstract: The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: The present disclosure relates a method, device, electronic apparatus, and system of providing information for breathing training, and storage medium. The method of providing information for breathing training includes receiving first data input on a first display interface, the first data including breathing training time data; and presenting output data on a second display interface, the output data including breathing beat image prompting an exhaling action and an inhaling action by using alternate graphics.

Abstract: The present disclosure relates to a multifunctional therapeutic biological material and preparation method thereof. The process steps of the preparation method are as follows: (1) preparing various three-dimensional micro/nano composite structure on the surface of a biomedical material by using femtosecond laser double pulses; (2) further preparing a nano-flower structure on the three-dimensional micro/nano composite structure by using hydrothermal synthesis method to construct a heterogeneous structure consisting of the three-dimensional micro/nano composite structure and the nano-flower structure; (3) putting the prepared heterogeneous structure into a mixed solution containing gold ions and platinum ions, and by using ultraviolet light reduction method, reducing in situ into gold-platinum bimetallic nanoparticles on the heterogeneous structure to obtain the multifunctional therapeutic biological material.

Abstract: A public event administrating system is disclosed. The public event involves a plurality of individuals and the administrating system includes: a data collecting module, a data processing module, a medical resource scheduling module, and a grid administrating module. The data collecting module is configured to acquire initial data about the public event from a plurality of data sources. The data processing module is configured to process the initial data to acquire processed data. The medical resource scheduling module is configured to receive an individual service request and allocate currently available medical resources to an individual requesting service at least according to the individual service request. And, the grid administrating module is configured to divide a geographic region managed by the administrating system into a plurality of grids, and assign a plurality of grid administrators to the plurality of grids to respectively administrate individuals in the plurality of grids.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: The present disclosure relates to a graphene-nanoflower shaped MXene composite material, preparation method and application thereof, which belongs to the field of negative electrode materials for supercapacitors. In the present disclosure, a space-time shaping femtosecond laser is utilized to process MXene target in graphene oxide nanoflake dispersion, so as to synthesize a graphene-nanoflower shaped MXene composite material in one-step. This nanoflower shaped MXene has adjustable size and morphology and an extremely large specific surface area; when it is used in an electrode material for supercapacitors, the supercapacitor exhibits an extremely high specific capacitance and good cycle stability. This method utilizes a space-time shaping femtosecond laser to synthesize the graphene-nanoflower shaped MXene composite material, which is highly controllable, and can be used to uniformly prepare the material in large-scale. It has provided a new way for synthesis of materials.

Abstract: When generating anatomical maps (e.g., anatomical geometries and/or electrophysiology maps), it can be desirable to analyze whether or not a collected data point was collected from a region of interest. During an electrophysiology study, for example, an electroanatomical mapping system collects electrophysiology data points, each including an electrogram signal. By defining both a window of interest and a window of exclusion within the electrogram signal, the electroanatomical mapping system can analyze collected data points to determine whether or not they should be included in a map. In particular, the electroanatomical mapping system can compare the electrophysiology signal within the window of interest and the window of exclusion with respect to at least one signal parameter and add the data point to the map if the comparison satisfies at least one corresponding inclusion criterion. Applicable signal parameters include maximum peak-to-peak voltage, conduction velocity, and electrogram morphology.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof. Methods associated with the preparation and use of the disclosed compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed.

Abstract: A three-dimensional imaging system and method are provided. The three-dimensional imaging system includes: an ultrashort pulse laser light source configured to generate a detection beam; a supercontinuum spectrum generator configured to generate a supercontinuum spectrum based on the detection beam passing through the supercontinuum spectrum generator; a pulse separation delayer configured to generate a continuous pulse sequence of different wavelengths with a time interval based on the supercontinuum spectrum; a multi-frequency pulse interference fringe generator configured to generate multi-frequency interference fringe patterns of different wavelength ranges with a time interval based on the continuous pulse sequence; and an image acquisition device configured to acquire an optical signal reflected by a sample irradiated by the multi-frequency interference fringe patterns to obtain a three-dimensional topography of the sample.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A method and a device for processing a unidirectional flow surface, the method includes: generating a grayscale map having gradually changed grayscale values; generating a holographic phase map having a bionic light spot with gradually changed energies based on the grayscale map; loading the holographic phase map onto a spatial beam shaper; and focusing a laser beam on a surface of an object to be processed after the laser beam passes through the spatial beam shaper, to process structural units having unidirectional flow characteristics on the surface of the object to be processed.