Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: Disclosed is a system and method for communication using an efficient fiber-to-chip grating coupler with a high coupling efficiency.

Abstract: In an embodiment, a phase shifter includes: a light input end; a light output end; a p-type semiconductor material, and an n-type semiconductor material contacting the p-type semiconductor material along a boundary area, wherein the boundary area is greater than a length from the light input end to the light output end multiplied by a core width of the phase shifter.

Abstract: The present invention is directed to 3-heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: A processing application stored on a processing server receives a request to join an application server from a client device. The processing application identifies a targeted application server from a set of application servers, a private internet protocol (IP) address for the targeted application server, and a port number associated with the targeted application server. The processing application generates a token based at least in part on the private IP address for the targeted application server. The processing application maps the private IP address to a virtual IP (VIP) address. The processing application transmits the VIP address, the private IP address, the port number, and the token to the client device.

Abstract: A hybrid compensation system is electrically connected between a power grid and a load. The hybrid compensation system includes an active filter, a passive filter and a control unit. The active filter generates an output current. The active filter includes a switching circuit, a DC bus capacitor and a filtering inductor. The control unit includes a voltage controller, a first reactive current detector, a harmonic current compensator, a current loop controller and a modulator. The voltage controller generates a first current given signal according to a bus voltage of the DC bus capacitor and a reference voltage. The first reactive current detector generates a second current given signal. The harmonic current compensator generates a third current given signal. The current loop controller generates a control signal. The modulator generates a driving signal according to the control signal.

Abstract: The present invention is directed to bicyclo[4.1.0]heptane pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

Abstract: The present invention is directed to heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

Abstract: The present invention is directed to bicyclo[4.1.0]heptane pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: A control method of a multilevel converter includes: classifying power modules that start working, need to update an output state or stop working to form m power module groups; and controlling power modules in a same one of the power module groups to start working, update the output state or stop working at the same time, and sequentially controlling the m power module groups to start working, or update the output state or stop working, according to a preset time interval. The number of power modules in each power module group is less than or equal to a preset value, causing a change value of an output level of the each power module group to be less than or equal to a preset voltage value.

Abstract: A control method of a multilevel converter includes: classifying power modules that start working, need to update an output state or stop working to form m power module groups; and controlling power modules in a same one of the power module groups to start working, update the output state or stop working at the same time, and sequentially controlling the m power module groups to start working, or update the output state or stop working, according to a preset time interval. The number of power modules in each power module group is less than or equal to a preset value, causing a change value of an output level of the each power module group to be less than or equal to a preset voltage value.

Abstract: A driving method for power semiconductor switches in an H-bridge circuit is provided. The method includes: calculating a start time and an end time of a zero level of an output voltage and determining a zero level section based on the start time and end time of the zero level; and driving an upper power semiconductor switch of a first bridge arm and an upper power semiconductor switch of a second bridge arm to be on simultaneously or driving a lower power semiconductor switch of the first bridge arm and a lower power semiconductor switch of the second bridge arm to be on simultaneously in the zero level section.

Abstract: A hybrid topology power converter includes a three-level circuit module and a cascaded H-bridge circuit module. A control method includes the following steps. Firstly, a zero sequence component is injected into a total modulation wave, thereby generating a compensated total modulation wave. Then, a first voltage signal is generated according to the compensated total modulation wave. An H-bridge modulation wave is generated according to the compensated total modulation wave and the first voltage signal. A three-level driving signal is generated according to the first voltage signal, and an H-bridge driving signal is generated according to the H-bridge modulation wave. A duty cycle of at least one switch element of the three-level circuit module is adjusted according to the three-level driving signal. A duty cycle of at least one switch elements of the cascaded H-bridge circuit module is adjusted according to the H-bridge driving signal.

Abstract: A driving method for power semiconductor switches in an H-bridge circuit is provided. The method includes: calculating a start time and an end time of a zero level of an output voltage and determining a zero level section based on the start time and end time of the zero level; and driving an upper power semiconductor switch of a first bridge arm and an upper power semiconductor switch of a second bridge arm to be on simultaneously or driving a lower power semiconductor switch of the first bridge arm and a lower power semiconductor switch of the second bridge arm to be on simultaneously in the zero level section.

Abstract: A cover for a tablet, a mobile phone or a laptop bottom and a watch strap, consisting at least partly of a polymer composition containing: (A) a thermoplastic elastomer, and (B) 1-30 wt. % of an epoxydized plasticizer.

Abstract: A pre-charge control method for a hybrid multilevel power converter comprises steps of: (a) controlling access of the current-limiting resistor unit, limiting current from the AC power via the current-limiting resistor unit, and outputting the current; (b) controlling the second capacitor unit to bypass, and charging the first capacitor unit; (c) controlling the access of the second capacitor unit when the first capacitor unit is charged to a third preset voltage, and charging the first and second capacitor units at the same time; (d) controlling the first capacitor unit to bypass when the second capacitor unit is charged to a fourth preset voltage, or the first capacitor unit is charged to a first preset voltage, and charging the second capacitor unit; and (e) controlling the access of the first capacitor units and the current-limiting resistor unit to bypass when the second capacitor unit is charged to a second preset voltage.

Abstract: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.