Patents by Inventor Lan Wu
Lan Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240246975Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof. Methods associated with the preparation and use of the disclosed compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed.Type: ApplicationFiled: December 4, 2023Publication date: July 25, 2024Inventors: Hang Chu, Hongyan Guo, Lan Jiang, Jiayao Li, David W. Lin, Hyung-Jung Pyun, Qiaoyin Wu, Hong Yang, Adam D. Zajdlik, Jennifer R. Zhang
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Patent number: 11932704Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: GrantFiled: October 29, 2021Date of Patent: March 19, 2024Assignee: SANOFIInventors: Zhi-Yong Yang, Gary J. Nabel, Lan Wu, Edward Seung, Ronnie Wei, Jochen Beninga, Ercole Rao, Wulf Dirk Leuschner, Christian Beil, Christian Lange, Carsten Corvey
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Publication number: 20240059798Abstract: Disclosed are antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptide complexes; cells, pharmaceutical compositions, and kits containing such polypeptide complexes; and methods of using such polypeptide complexes.Type: ApplicationFiled: December 21, 2022Publication date: February 22, 2024Inventors: LING XU, LAN WU, EDWARD SEUNG, ZHI-YONG YANG, GARY J. NABEL, ELIAS ZERHOUNI, RONNIE R. WEI, HAO CHEN, MARK GRECI, NICHOLAS JONES
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Publication number: 20230357401Abstract: The disclosure provides methods of treating viral infection using trispecific binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind a CD38 polypeptide (e.g., human and/or cynomolgus monkey CD38 polypeptides), a CD28 polypeptide, and a CD3 polypeptide.Type: ApplicationFiled: November 11, 2022Publication date: November 9, 2023Inventors: Lan WU, Ling XU, Edward SEUNG, Ronnie WEI, Gary NABEL, Zhi-Yong YANG, Tarik DABDOUBI, Béatrice CAMERON, Cendrine LEMOINE, Catherine PRADES
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Publication number: 20230352497Abstract: A display may have one or more bent portions. To increase the magnitude of curvature in a display and/or to allow for compound curvature in the display, a display panel may be partially formed in a planar state. The partial display panel is then bent to have desired curvature. After the partial display panel is bent, additional display components that are susceptible to damage during the bending process may be added to complete the display panel. A flexible printed circuit may be formed directly on the display panel using precise deposition of conductive material. By forming the flexible printed circuit layer-by-layer directly on the display panel, no substantive pressure needs to be applied to the display panel. Electrical connections may therefore be made to the display panel in regions of the display with high levels of curvature and/or with compound curvature without causing front-of-screen artifacts for the display panel.Type: ApplicationFiled: March 1, 2023Publication date: November 2, 2023Inventors: Meng-Tse Chen, Anshi Liang, Arnoldus A Barlian, Bayu A Thedjoisworo, Boris A Russ, Chun-Hsien Lee, Chun-Lan Wu, Han-Chieh Chang, Jiming Yu, Marc J DeVincentis, Nathan K Gupta, Paolo Sacchetto, Paul S Drzaic, Zhen Zhang, Ziyang Zhang
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Publication number: 20230343914Abstract: Conductive traces may be conformally wrapped around the side of a display panel that includes an array of display pixels. The conductive traces may electrically connect contacts on an upper surface of the display panel to corresponding contacts on a flexible printed circuit that is attached to a lower surface of the display panel. The side-wrapped conductive traces may be interposed between first and second insulating layers. The flexible printed circuit may have a multi-step interface that is electrically connected to the side-wrapped conductive traces. A system-in-package including a display driver integrated circuit may be mounted to the flexible printed circuit. The system-in-package may include a plurality of redistribution layers that electrically connect contacts on the display driver integrated circuit to contacts on the flexible printed circuit.Type: ApplicationFiled: March 16, 2023Publication date: October 26, 2023Inventors: Han-Chieh Chang, Anshi Liang, Arnoldus A Barlian, Bayu A Thedjoisworo, Boris A Russ, Chun-Lan Wu, Ken Hsuan Liao, Marc J DeVincentis, Meng-Tse Chen, Nathan K Gupta, Paolo Sacchetto, Paul S Drzaic, Po-Jui Chen, Ying-Chih Wang, Yong Sun, Zhen Zhang, Ziyang Zhang
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Publication number: 20230235092Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; chimeric antigen receptors (CARs), cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.Type: ApplicationFiled: September 28, 2022Publication date: July 27, 2023Inventors: Ronnie Rong WEI, Ling XU, Zhi-Yong YANG, Edward SEUNG, Gary J. NABEL, Lan WU, Mark GRECI, Hao CHEN
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Publication number: 20230220079Abstract: Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: ApplicationFiled: March 13, 2023Publication date: July 13, 2023Inventors: Christian BEIL, Jochen BENINGA, Joerg BIRKENFELD, Gary J. NABEL, Huawei QIU, Ercole RAO, Joerg REGULA, Edward SEUNG, Ronnie WEI, Lan WU, Zhen XING, Ling XU, Zhi-Yong YANG
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Publication number: 20230203199Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, chimeric antigen receptors (CARs), immune cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.Type: ApplicationFiled: September 28, 2022Publication date: June 29, 2023Inventors: Ronnie Rong WEI, Ling XU, Zhi-Yong YANG, Edward SEUNG, Gary J. NABEL, Lan WU, Mark GRECI, Hao CHEN
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Patent number: 11613576Abstract: Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: GrantFiled: April 8, 2020Date of Patent: March 28, 2023Assignee: SANOFIInventors: Christian Beil, Jochen Beninga, Joerg Birkenfeld, Gary J. Nabel, Huawei Qiu, Ercole Rao, Joerg Regula, Edward Seung, Ronnie Wei, Lan Wu, Zhen Xing, Ling Xu, Zhi-Yong Yang, Béatrice Cameron, Tarik Dabdoubi, Cendrine Lemoine, Catherine Prades
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Patent number: 11530268Abstract: The disclosure provides methods of treating viral infection using trispecific binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind a CD38 polypeptide (e.g., human and/or cynomolgus monkey CD38 polypeptides), a CD28 polypeptide, and a CD3 polypeptide.Type: GrantFiled: October 8, 2019Date of Patent: December 20, 2022Assignee: SanofiInventors: Lan Wu, Ling Xu, Edward Seung, Ronnie Wei, Gary Nabel, Zhi-Yong Yang, Tarik Dabdoubi, Béatrice Cameron, Cendrine Lemoine, Catherine Prades
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Patent number: 11518400Abstract: A method for detecting, a roadside object including, a three-dimensional object in the vicinity of a vehicle on a road surface includes recording at least one data set including a plurality of data points associated with a region in a lateral vicinity of the vehicle, the region at least partially including at least one wheel of the vehicle and the road surface, where each data point includes according, to whether it corresponds to the at least one wheel to the road surface or to the roadside object, determining a distance between a data point classified as corresponding to the at least one wheel and a data point classified as corresponding to the roadside object and generating a signal if the distance is below at least one threshold value.Type: GrantFiled: December 20, 2018Date of Patent: December 6, 2022Assignee: Motherson Innovations Company LimitedInventors: Reinhold Langbein, Lan Wu
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Publication number: 20220119553Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: ApplicationFiled: October 29, 2021Publication date: April 21, 2022Inventors: Zhi-Yong YANG, Gary J. NABEL, Lan WU, Edward SEUNG, Ronnie WEI, Jochen BENINGA, Ercole RAO, Wulf Dirk LEUSCHNER, Christian BEIL, Christian LANGE, Carsten CORVEY
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Patent number: 11240973Abstract: An artificially intelligent harvest and reuse system for planting vegetables has a first mechanic arm moving a plurality of planting plates around a first conveyor, a second conveyor, a first shelf and a second shelf. The planting plates are sent to a connecting conveyor for the grown vegetables thereon to be picked up by a second mechanic arm and further sent to a root cutting apparatus then to a packaging apparatus, while the empty planting plates are further sent to an exit end of the first conveyor and a third mechanic arm places nursery foams with sprouts from a storage area onto the empty planting plates. Then the refilled planting plates are sent back to the corresponding shelf via the second conveyor and placed back into the corresponding layers neatly by the first mechanic arm on a first distributing apparatus.Type: GrantFiled: April 23, 2020Date of Patent: February 8, 2022Assignee: Sunpower Grand Holdings Pte. Ltd.Inventors: Yu-Chien Wu, Li-Jen Wu, Hsin-Lan Wu
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Patent number: 11192960Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: GrantFiled: November 16, 2020Date of Patent: December 7, 2021Assignee: SanofiInventors: Zhi-Yong Yang, Gary J. Nabel, Lan Wu, Edward Seung, Ronnie Wei, Jochen Beninga, Ercole Rao, Wulf Dirk Leuschner, Christian Beil, Christian Lange, Carsten Corvey
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Patent number: 11186649Abstract: The disclosure provides binding proteins that bind CD38 polypeptides, e.g., human and cynomolgus monkey CD38 polypeptides. For example, the binding proteins can be monospecific, bispecific, or trispecific binding proteins with at least one antigen binding domain that binds a CD38 polypeptide. The disclosure also provides methods for making binding proteins that bind CD38 polypeptides and uses of such binding proteins.Type: GrantFiled: October 9, 2018Date of Patent: November 30, 2021Assignee: SanofiInventors: Lan Wu, Ling Xu, Edward Seung, Ronnie Wei, Gary Nabel, Zhi-Yong Yang, Tarik Dabdoubi, Béatrice Cameron, Cendrine Lemoine, Catherine Prades
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Publication number: 20210061925Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: ApplicationFiled: November 16, 2020Publication date: March 4, 2021Inventors: Zhi-Yong YANG, Gary J. NABEL, Lan WU, Edward SEUNG, Ronnie WEI, Jochen BENINGA, Ercole RAO, Wulf Dirk LEUSCHNER, Christian BEIL, Christian LANGE, Carsten CORVEY
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Patent number: 10882922Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.Type: GrantFiled: April 13, 2017Date of Patent: January 5, 2021Assignee: SANOFIInventors: Zhi-Yong Yang, Gary J. Nabel, Lan Wu, Edward Seung, Ronnie Wei, Jochen Beninga, Ercole Rao, Wulf Dirk Leuschner, Christian Beil, Christian Lange, Carsten Corvey
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Patent number: D990693Type: GrantFiled: October 8, 2021Date of Patent: June 27, 2023Assignee: AZUNI INTERNATIONAL CO., LTD.Inventor: Li-Lan Wu
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Patent number: D990694Type: GrantFiled: October 14, 2021Date of Patent: June 27, 2023Assignee: AZUNI INTERNATIONAL CO., LTD.Inventor: Li-Lan Wu