Abstract: Optical fiber based acoustic sensors are provided herein. The optical fiber based acoustic sensors described herein include acoustically responsive optical structures configured to detect and receive acoustic signals, including ultrasound signals, and provide associated optical signals to a system for processing and interpretation to implement tracking, location, and imaging capabilities. Optical fiber based sensors provided herein may be disposed at ends of or along the length of optic fibers. Optical fiber based sensors may be included within various devices, including, for example, medical devices.

Abstract: The optical fiber with an acoustically sensitive fiber Bragg grating includes an optical fiber core with a pair of fiber Bragg gratings formed therein, such that each of the fiber Bragg gratings is spaced apart from the other. A cladding material is disposed on and surrounds at least a portion of the optical fiber core. The cladding material has at least one material property associated therewith, where the at least one material property may be a smaller Young's modulus than a Young's modulus of the optical fiber core, a larger photo-elastic coefficient than a photo-elastic coefficient of the optical fiber core, or combinations thereof. An ultrasound sensor includes at least one of the optical fibers embedded in a polymer layer, along with a backing layer and an acoustic matching layer.

Abstract: Mixed sensor array devices are provided herein. Mixed sensor arrays as described herein include acoustic energy generating elements and optical fiber based acoustic sensors. Optical fiber based sensors may optical structures responsive to physical parameters including acoustic signals, pressure, and temperature, and are configured to detect and receive acoustic signals and other physical parameters and provide associated optical signals to a system for processing and interpretation to implement tracking, location, imaging, and other sensing capabilities. Optical fiber based sensors provided herein may be disposed at ends of or along the length of optic fibers. Optical fiber based sensors may be included within various devices, including, for example, medical devices.

Abstract: A method for producing sclareol by fermentation of cigar tobacco flower buds is provided, including: mixing cigar tobacco flower buds with deionized water, sterilizing and adding edible yeast, then fermenting at 25-30° C. and 100-300 rpm/min for 24-30 h. This method uses cigar tobacco flower buds as the sole raw material, without adding additional nutrients, and only ferments tobacco flower buds with edible yeast to synthesize sclareol. Meanwhile, this method has extremely high synthesis efficiency.

Abstract: A method for producing sclareol by fermentation of cigar tobacco flower buds is provided, including: mixing cigar tobacco flower buds with deionized water, sterilizing and adding edible yeast, then fermenting at 25-30° C. and 100-300 rpm/min for 24-30 h. This method uses cigar tobacco flower buds as the sole raw material, without adding additional nutrients, and only ferments tobacco flower buds with edible yeast to synthesize sclareol. Meanwhile, this method has extremely high synthesis efficiency.

Abstract: This disclosure is directed an electrode and an electrochemical device having an electrode. The electrode includes a body with an active material that can react with ions in an electrochemical reaction within the electrochemical device. The body has a first surface that can abut against electrolyte of a separator of the electrochemical device, and second surfaces that define a plurality of cavities extending a depth from the first surface into the electrode. The plurality of cavities define pathways into the electrode that receive the electrolyte. The pathways improve ion transfer from the electrolyte to an inner subset of the active material that is located closer to one or more of the pathways than to the first surface.

Abstract: In some embodiments, after receiving a first set of video segments of a video, a method starts a first computing instance and receives a video segment of the video using the first computing instance. A measurement is calculated based on receiving the video segment. The method uses the measurement to determine whether the first computing instance should continue to be used to receive video segments in the video or should be terminated to not receive video segments in the video.

Abstract: The present disclosure features useful methods to treat cancer, e.g., in a subject in need thereof. In some embodiments, the methods described include administering an agent that reduces the level and/or activity of BRM/BRG1 in combination with an immunotherapy. In some embodiments, the immunotherapy is administered concurrently with the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject. In some embodiments, the immunotherapy is administered prior to the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject. In some embodiments, the immunotherapy is administered subsequent to the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject.

Abstract: The present provides an electrospinning apparatus for fabricating a nanofiber of core-shell structure, including a high-voltage electrostatic generator, a frame and a liquid brusher. A horizontally moving means is connected to the frame, and the horizontally moving means is connected with the liquid brusher. A chain-drive mechanism and a first reservoir are provided below the liquid brusher, the chain-drive mechanism includes a first sprocket and a second sprocket, and a chain is connected between the first sprocket and the second sprocket. The chain is engaged with a spray sprocket, and the spray sprocket is connected with a first motor via a revolving shaft. A core solution is contained in the first reservoir, and the lower portion of the spray sprocket is immersed in the core solution. The horizontally moving means drives the liquid brusher to move along the chain, and the liquid brusher brushes the shell solution over the chain.

Abstract: The present invention relates to a 3CL protease small-molecule inhibitor for treating or preventing a coronavirus infection, and the use thereof. Specifically, the present invention relates to a compound of formula (I) or an isotopically labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer, or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof, and the use thereof in the preparation of a drug for treating or preventing a coronavirus infection or a disease or symptom caused by a coronavirus.

Abstract: An apparatus for imaging a target and a process of making the apparatus are provided. The apparatus includes a housing and a distal portion. The distal portion includes an acoustic subarray on a first substrate configured to transmit acoustic signals toward the target. The distal portion includes an optical subarray on a second substrate, configured to detect acoustic signals from the target. The distal portion includes an input/output (I/O) region including one or more optical I/O channels. The one or more optical I/O channels is configured to bend optical signals between the optical subarray and the one or more optical I/O channels.

Abstract: A wafer has a layer containing silicon, a layer of polycrystalline diamond deposited on the silicon-containing layer, and a bow-compensation layer on the other side of the silicon-containing layer for reducing wafer-bow. A method of making a bonded structure includes an activation process for creating dangling bonds on the surface of one substrate, followed by contact-bonding the surface to a second substrate at low temperature. A bonded structure may include two substrates contact bonded to each other, one substrate including a layer containing silicon, a layer of polycrystalline diamond, a bow-compensation layer for reducing wafer-bow of the first substrate, and the other substrate including gallium nitride, silicon carbide, lithium niobate, lithium tantalate, gallium arsenide, indium phosphide, or another suitable material other than diamond.

Abstract: A computer-implemented method of generating editable free-viewport videos is provided. A plurality of video of a scene from a plurality of views is obtained. The scene comprises includes an environment and one or more dynamic entities. A 3D bounding-box is generated for each dynamic entity in the scene. A computer device encodes a machine learning model including an environment layer and a dynamic entity layer for each dynamic entity in the scene. The environment layer represents a continuous function of space and time of the environment. The dynamic entity layer represents a continuous function of space and time of the dynamic entity. The dynamic entity layer includes a deformation module and a neural radiance module. The deformation module is configured to deform a spatial coordinate in accordance with a timestamp and a trained deformation weight. The neural radiance module is configured to derive a density value and a color.

Abstract: This disclosure relates to antibodies, antigen-binding fragments, protein constructs, and chimeric antigen receptors that bind to a complex comprising an AFP peptide and an MHC molecule, and the uses thereof.

Abstract: The embodiments of the present disclosure relate to the field of battery technology, and provide a battery lithium plating detection method, device, management system, battery and electric device. The lithium plating detection method may include: charging a to-be-tested battery and stopping charging after the to-be-tested battery has been charged to a first state of charge (SOC), and allowing the to-be-tested battery to rest; obtaining a first voltage of the to-be-tested battery upon completion of electrochemical equilibrium; collecting a second voltage of the to-be-tested battery; and determining that lithium plating has occurred in the to-be-tested battery in case where a difference between the second voltage and the first voltage is greater than a first voltage threshold.

Abstract: Described herein are methods and non-transitory computer-readable media configured to obtain a plurality of images from a plurality of image scanning orientations for an object. A rigid registration is performed to the plurality of images to obtain a transformation matrix to normalize the plurality of images from their respective image spaces to a normalized image space. Each normalized image comprises a plurality of voxels. A machine learning model comprising an implicit representation of a high-resolution image is trained using the normalized images, wherein the high-resolution image comprises more voxels than the voxels in the normalized images. The high-resolution image is generated based on the trained machine learning model. The plurality of images are a plurality of anisotropic 2D images, while the high resolution image can be a 2D or 3D high resolution image.

Abstract: The optical sensor circuit is an optical circuit for routing input optical signals through an array of optical sensors. The optical sensor circuit includes an optical input port for receiving a plurality of input optical signals within a single input channel, where each of the input optical signals has a unique wavelength associated therewith. A wavelength-division demultiplexer is coupled to the optical input port to demultiplex the plurality of input optical signals, and a plurality of optical sensors are coupled to the wavelength-division demultiplexer for respectively receiving the plurality of input optical signals and outputting a corresponding plurality of output optical signals. A wavelength-division multiplexer is coupled to the plurality of optical sensors to multiplex the plurality of output optical signals into a single output channel, and an optical output port is coupled to the wavelength-division multiplexer for outputting the plurality of output optical signals in the single output channel.

Abstract: An isolated cell membrane potential detection system can measure a cell membrane current change when light having different parameters such as wavelength, energy density, pulse width, and repetition rate stimulates a cell to be detected, to detect whether the biological electrical activity of the cell can be regulated by light, and to detect the specificity of the light regulation parameters of the cell. In the light regulation cell membrane potential detection system, a method of progressively adjusting and detecting with multiple optical parameters from small to large is used to measure a cell membrane current change in different periods under a certain photostimulation parameter for each group of cells, so as to quickly and efficiently detect which type of optical signal can regulate the characteristics of the cell such as the generation of a membrane current, photostimulation parameter specificity, and an energy threshold.

Abstract: The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.

Abstract: A deep neural network based hair rendering system is presented to model high frequency component of furry objects. Compared with existing approaches, the present method can generate photo-realistic rendering results. An acceleration method is applied in our framework, which can speed up training and rendering processes. In addition, a patch-based training scheme is introduced, which significantly increases the quality of outputs and preserves high frequency details.