Abstract: An acoustic sensing system for an imaging system includes an acoustic probe array including at least one optical whispering gallery mode (WGM) resonator for sensing acoustic signals, at least one coupling waveguide, and a polymer, a light source coupled to a first end of the waveguide, and a light detector coupled to a second end of the waveguide. The polymer has a convex upper boundary engineered to enhance acoustic focus on the optical WGM resonator, the resonator and the waveguide each have higher refractive indices than a refractive index of the polymer, the waveguide is optically coupled to at least one optical WGM resonator, the waveguide is spaced apart from the optical WGM resonator to which it is coupled by a separation gap, and the polymer encases the optical WGM resonator an a portion of the waveguide to which it is coupled and fills the separation gap.

Abstract: Mixed sensor array devices are provided herein. Mixed sensor arrays as described herein include acoustic energy generating elements and optical fiber based acoustic sensors. Optical fiber based sensors may optical structures responsive to physical parameters including acoustic signals, pressure, and temperature, and are configured to detect and receive acoustic signals and other physical parameters and provide associated optical signals to a system for processing and interpretation to implement tracking, location, imaging, and other sensing capabilities. Optical fiber based sensors provided herein may be disposed at ends of or along the length of optic fibers. Optical fiber based sensors may be included within various devices, including, for example, medical devices.

Abstract: Provided are various embodiments relating to anti-IL17A antibodies and IL17Ra ECD polypeptides that bind to IL17A. In various embodiments, such anti-IL17A antibodies or IL17Ra ECD polypeptides can be used in methods to treat IL17-induced conditions in subjects, such as humans or companion animals, such as canines, felines, and equines. Also provided are various embodiments relating to IgG Fc variant polypeptides having one or more amino acid substitutions for reducing binding to C1q and/or CD16. In some embodiments, the IgG Fc variants and/or polypeptides comprising the IgG Fc variants (e.g., fusion polypeptides comprising the IgG Fc variants and the anti-IL17A antibodies and/or IL17Ra ECD polypeptides described herein) may have reduced complement-mediated immune responses and/or antibody-dependent cell-mediated cytotoxicity.

Abstract: Systems and methods for measuring a temperature using an optical whispering gallery mode (WGM) resonator are disclosed. The system includes a WGM resonator operatively coupled to a tunable laser source and a detector, as well as a computing device. The computing device is configured to transform a transmission spectrum from the detector into a measured barcode that includes a matrix of values indicative of at least one characteristic of the transmission spectrum. The computing device is further configured to transform the measured barcode into a temperature based on a relative collective shift of the measured barcode from a reference barcode selected from a predetermined library of reference barcodes.

Abstract: Optical whispering gallery mode (WGM) resonator-based acoustic sensors, imaging systems that make use of the acoustic sensors, and methods of detecting ultrasound waves using the acoustic sensors are disclosed.

Abstract: An apparatus may include one or more optical fibers, one or more optical waveguides, and multiple resonator nodes arranged in an array of sensing locations. Each resonator node may include an optical coupling between an optical waveguide and an optical fiber having a set of resonant frequencies at a respective sensing location. Each resonator node may be further configured to communicate a set of signals corresponding to at least one shift in the set of resonant frequencies in the optical fiber at the respective sensing location.

Abstract: Systems and methods for enhancing sensitivity in a sensor with exceptional points (EPs), including: providing a sensor in the form of an exception-point (EP)-enhanced sensor; providing one or optical fibers associated with the EP-enhanced sensor; providing a scatterer; and/or providing a reflective component, the reflective component influencing a mode coupling of the EP-enhanced sensor. Where the sensor is a microresonator: coupling one or more modes of the microresonator via a bidirectional coupling channel and a unidirectional coupling channel; manipulating the mode coupling by a scatterer and a reflective component, the reflective component influencing the mode coupling of the resonator; steering, via the reflective component, the microresonator around EPs; and/or sending, via the reflective component, one or more phase changes in response to external perturbations back to the microresonator.

Abstract: A gas sensing system includes a packaged photonic sensor including a resonant sensor and a control system. The control system includes a light module, a receiver module, and a core module. The light module includes a light source to generate light and transmit it to the photonic sensor. The receiver module receives light signals from the photonic sensor and converts them to digital signals. The core module includes a computing device and is programed to: control the light module to cause the light module to generate and transmit light to the packaged photonic sensor, receive the digital signals from the receiver module, and detect one or both of a concentration of a gas that interacted with the resonant sensor and an identification of the gas whose molecules interacted with the resonant sensor based at least in part on the received digital signals from the receiver module.

Abstract: Sensing apparatuses and method of making the sensing apparatuses are disclosed herein. In some variations, a sensing apparatus can comprise at least one optical waveguide, and at least one whispering gallery mode (WGM) resonator configured to propagate a set of WGMs, where the WGM resonator communicates to the at least one optical waveguide a set of signals corresponding to the set of WGMs. In some variations, a polymer structure may encapsulate the at least one WGM resonator and/or the at least one optical waveguide. Furthermore, in some variations, the WGM resonator(s) may have one or more selectable modes with different bandwidth and sensitivity for sensing, which may, for example, enable tailoring the sensing apparatus to specific applications having certain bandwidth and/or sensitivity requirements.

Abstract: An apparatus may include one or more optical fibers, one or more optical waveguides, and multiple resonator nodes arranged in an array of sensing locations. Each resonator node may include an optical coupling between an optical waveguide and an optical fiber having a set of resonant frequencies at a respective sensing location. Each resonator node may be further configured to communicate a set of signals corresponding to at least one shift in the set of resonant frequencies in the optical fiber at the respective sensing location.

Abstract: Disclosed herein are apparatus and methods for acoustic imaging. The disclosed embodiments include an optical sensor. The optical sensor may include an acoustic stack. The acoustic stack may include a backing layer that supports an optical layer. The optical layer may include an optical waveguide and a tuning device configured to tune an optical propagation property of the optical waveguide. The optical waveguide may include a core region and one or more cladding regions. The one or more cladding regions may have optical refractive index less than that of the core region.

Abstract: Sensing apparatuses and method of making the sensing apparatuses are disclosed herein. In some variations, a sensing apparatus can comprise at least one optical waveguide, and at least one whispering gallery mode (WGM) resonator configured to propagate a set of WGMs, where the WGM resonator communicates to the at least one optical waveguide a set of signals corresponding to the set of WGMs. In some variations, a polymer structure may encapsulate the at least one WGM resonator and/or the at least one optical waveguide. Furthermore, in some variations, the WGM resonator(s) may have one or more selectable modes with different bandwidth and sensitivity for sensing, which may, for example, enable tailoring the sensing apparatus to specific applications having certain bandwidth and/or sensitivity requirements.

Abstract: A displacement sensor including an optical whispering gallery mode (WGM) microresonator and a package encasing at least a portion of the WGM microresonator, the package comprising polydimethylsiloxane (PDMS). The WGM microresonator can be configured as a sensor and used in a displacement detection system that can detect displacement with high quality. Artificial intelligence can be implemented in the displacement detection system for improved sensing of different variables and/or pinpointing the location of perturbations.

Abstract: An acousto-optic imaging system may include at least one transducer that transmits an ultrasound signal having a fundamental frequency f. The acousto-optic imaging system includes at least one optical sensor that may produce one or more optical responses upon receiving harmonic-related ultrasound echoes corresponding to the transmitted ultrasound signal. For example, the one or more optical sensors may have a bandwidth ranging from at least f/M to Nf, where M and N are integers greater than 1.

Abstract: Described and provided herein are novel antibodies for Claudin 18.2. Also described and provided are pharmaceutical compositions of the antibodies and methods of use for the treatment of cancer.

Abstract: A compact mixed ultrasound transducer including a transducer case, a source array configured comprising at least one acoustic energy generating transducer and configured to transmit acoustic waves; and an optical receiver array including at least one optical sensor and configured to detect acoustic echoes associated with the acoustic waves is provided. The mixed ultrasound transducer may have a compact geometry facilitated by various features.

Abstract: An optical module, comprising a circuit board (110), a photoelectric assembly (130) electrically connected to the circuit board (110), an optical interface (120), and optical fiber (140) in optical communication with the photoelectric assembly (130) and the optical interface (120), and a fiber coiling member (150). The fiber coiling member (150) comprises a fiber coiling body (151) enclosing an accommodating cavity (1510), and the fiber coiling body (151) is provided with a bottom wall (1512) and a fiber coiling wall (1511) extending from the bottom wall (1512) in the thickness direction of the circuit board (110). The fiber coiling wall (1511) defines a peripheral boundary of the accommodating cavity (1510). The fiber coiling member (150) further comprises stop walls (152) arranged opposite to the bottom wall (1512) in the thickness direction of the circuit board (110), and protruding from the fiber coiling wall (1511) to the interior of the accommodating cavity (1510).

Abstract: A cerium-zirconium-aluminum-based composite material, a cGPF catalyst and a preparation method thereof are provided. The cerium-zirconium-aluminum-based composite material adopts a stepwise precipitation method, firstly preparing an aluminum-based pre-treated material, then coprecipitating the aluminum-based pre-treated material with zirconium and cerium sol, and finally roasting at high temperature to obtain the cerium-zirconium-aluminum-based composite material. The cerium-zirconium-aluminum-based composite material has better compactness and higher density, and when it is used in cGPF catalyst, it occupies a smaller volume of pores on the catalyst carrier, such that cGPF catalyst has lower back pressure and better ash accumulation resistance, which is beneficial to large-scale application of cGPF catalyst.

Abstract: The invention provides a fracture opening simulation device for hard brittle mudstone and shale with organic matter, it includes a simulated support, the lower part of the simulated support is connected with a storage bucket bottom block plate through a screw, the middle of the simulated support is provided with a support socket with a circular structure, the upper surface of the storage bucket bottom block plate is provided with a circular convex structure of a block plate boss, the block plate boss is closely inserted in the support socket, the upper surface of the simulated support is fixed connected with a core column storage barrel.

Abstract: A method of transmitting at least one optical signal through an add-drop filter includes directing the at least one optical signal into a first tapered optical fiber of the add-drop filter. The add-drop filter includes an active resonator side-coupled between the first tapered optical fiber and a second tapered optical fiber, and the active resonator is doped with at least one rare earth ion. A tuned optical gain is produced by delivering a tuned amount of pump laser energy to the at least one rare earth ion at a sub-lasing level, the tuned optical gain configured to compensate an intrinsic loss of the active resonator.