Abstract: Provided is a protein comprising an antibody or antigen-binding fragment and an interleukin molecule operably linked to the antibody or antigen-binding fragment. The antibody or antigen-binding fragment specifically binds to an immune checkpoint protein. The interleukin molecule is IL-10.

Abstract: Provided herein is related generally to the field of molecular biology and growth factor regulation. More specifically, provided herein are methods useful for treating cancer patient using c-Met inhibitor based on the identification of an increased c-Met expression and at least one c-Met gene alteration, e.g. c-Met mutation, c-Met fusion gene and c-Met gene amplification.

Abstract: Provided are a system and a method for testing an ability of an automated vehicle to pass a traffic circle without traffic lights. The system includes an automated vehicle, a traffic circle, a control center, an attitude sensor and a panorama camera. In the method, the control center receives a test request and then sends a driving command to drive the automated vehicle to enter the traffic circle to start the test. The attitude sensor obtains a tilt angle and sends it to the control center in real time. The panorama camera is configured to obtain a driving trajectory, a driving speed and a state of turn signals of the automated vehicle. The obtained information is compared to a standard by the control center to evaluate the ability of the automated vehicle to pass the traffic circle without traffic lights.

Abstract: Provided are various embodiments relating to anti-IL17A antibodies and IL17Ra ECD polypeptides that bind to IL17A. In various embodiments, such anti-IL17A antibodies or IL17Ra ECD polypeptides can be used in methods to treat IL17-induced conditions in subjects, such as humans or companion animals, such as canines, felines, and equines. Also provided are various embodiments relating to IgG Fc variant polypeptides having one or more amino acid substitutions for reducing binding to C1q and/or CD16. In some embodiments, the IgG Fc variants and/or polypeptides comprising the IgG Fc variants (e.g., fusion polypeptides comprising the IgG Fc variants and the anti-IL17A antibodies and/or IL17Ra ECD polypeptides described herein) may have reduced complement-mediated immune responses and/or antibody-dependent cell-mediated cytotoxicity.

Abstract: The present disclosure belongs to the technical field of extraction of fragrance substances, and specifically relates to Cymbidium goeringii balsam and a preparation method and use thereof. The present disclosure is implemented by cultivating multiple plants of Cymbidium goeringii with unravelling bloom collectively in a relatively small enclosed space, and enriching fragrance substances of Cymbidium goeringii in the air by lipid for adsorption. The method of the present disclosure can obtain Cymbidium goeringii balsam rich in a variety of fragrance components in a relatively short time. GC-MS detection indicates as many as 50 components. The present disclosure significantly improves the prior art in which only a small amount of fragrance components in Cymbidium goeringii can be extracted or even cannot be obtained. The present disclosure can be further used in extracting essential oils or applied directly.

Abstract: Provided are a method and a device for constructing autonomous driving test scenes, a terminal and a readable storage media. Primitive scenes are extracted from real traffic scenes to establish a primitive scene description model. The values of the description variables are selected from distribution intervals of the description variables of the primitive scenes, and the description variables are randomly sampled based on the distribution of the description variables to generate test primitive scenes by adopting an importance sampling based Monte Carlo method. The test primitive scenes are recombined according to the parameters of the elements of the test scene to generate the test scene. The present invention can directly simulate the actual complex system, so as to avoid the result distortion caused by the simplification of the complex system.

Abstract: Provided are various embodiments relating to anti-IL17A antibodies and IL17Ra ECD polypeptides that bind to IL17A. In various embodiments, such anti-IL17A antibodies or IL17Ra ECD polypeptides can be used in methods to treat IL17-induced conditions in subjects, such as humans or companion animals, such as canines, felines, and equines. Also provided are various embodiments relating to IgG Fc variant polypeptides having one or more amino acid substitutions for reducing binding to C1q and/or CD16. In some embodiments, the IgG Fc variants and/or polypeptides comprising the IgG Fc variants (e.g., fusion polypeptides comprising the IgG Fc variants and the anti-IL17A antibodies and/or IL17Ra ECD polypeptides described herein) may have reduced complement-mediated immune responses and/or antibody-dependent cell-mediated cytotoxicity.

Abstract: Provided herein are methods of treating cancer in a patient with a tyrosine kinase inhibitor. The method comprises: a) measuring the expression level of a protein kinase in a sample obtained from the patient; b) comparing the expression level of the protein kinase to a corresponding reference expression level; c) determining a likelihood of the patient being responsive to the tyrosine kinase inhibitor; and d) treating the patient whose expression level of the protein kinase indicates that the patient will be responsive with the tyrosine kinase inhibitor.

Abstract: An a system and method for chaos transfer between multiple detuned signals in a resonator mediated by chaotic mechanical oscillation induced stochastic resonance where at least one signal is strong and where at least one signal is weak and where the strong and weak signal follow the same route, from periodic oscillations to quasi-periodic and finally to chaotic oscillations, as the strong signal power is increased.

Abstract: The invention provides a pharmaceutical composition for injection comprising a NL-101 type compound and a preparation method thereof. The composition uses the NL-101 type compound as an active pharmaceutical ingredient, and the stability of the NL-101 type compound is improved by adding a chloride-containing stabilizing agent or using a co-solvent containing hydrochloric acid, so that the formulation can be stably produced and meet the requirements for clinical safe use.

Abstract: Provided are a method and a device for constructing autonomous driving test scenes, a terminal and a readable storage media. Primitive scenes are extracted from real traffic scenes to establish a primitive scene description model. The values of the description variables are selected from distribution intervals of the description variables of the primitive scenes, and the description variables are randomly sampled based on the distribution of the description variables to generate test primitive scenes by adopting an importance sampling based Monte Carlo method. The test primitive scenes are recombined according to the parameters of the elements of the test scene to generate the test scene. The present invention can directly simulate the actual complex system, so as to avoid the result distortion caused by the simplification of the complex system.

Abstract: The invention discloses a method for treating benign prostatic hyperplasia (BPH) using a burdock extract. The burdock extract is administered to a subject in need thereof to decrease prostate size of the subject. The burdock extract is obtained by extracting a sample of dried burdock seed using an extractant being water or an aqueous ethanol solution.

Abstract: The first type of semiconductor device includes a first fin structure extending in a first direction, a first gate, and a first slot contact disposed over the first fin structure. The first gate extends in a second direction and has a first gate dimension measured in the first direction. The first slot contact has a first slot contact dimension measured in the first direction. A second type of semiconductor device includes: a second fin structure extending in a third direction, a second gate, and a second slot contact disposed over the second fin structure. The second gate extends in a fourth direction and has a second gate dimension measured in the third direction. The second slot contact has a second slot contact dimension measured in the third direction. The second slot contact dimension is greater than the second gate dimension and greater than the first slot contact dimension.

Abstract: The present invention discloses a CRISPR/LpCas9 gene editing system and application thereof, the CRISPR/LpCas9 gene editing system includes a complex of LpCas9 protein and sgRNA, which can accurately locate a target DNA sequence and cleave DNA double strands. The LpCas9 protein has an amino acid sequence shown in SEQ ID NO:1; and the sgRNA has a nucleotide sequence shown in SEQ ID NO:2, or a modified sgRNA sequence based on SEQ ID NO: 2. The present invention can effectively solve the problems of heterologous codon bias and cytotoxicity in the application of SpCas9 in Lactobacillus paracasei. The gene editing is performed in cells or in vitro by introducing artificially designed CRISPR RNA and a repair template, which solves the problem of low electroporation efficiency caused by the strains' characteristics or relatively large carried plasmids, and has broad application prospects in the field of gene editing.

Abstract: An image processing chip test method comprising: controlling a power supply circuit to provide a first operating voltage to an image processing chip comprising a storage device; and when reading written first image data from the storage device, the test device receives a first error detection code corresponding to the first image data and determines whether the first error detection code means an error occurs. If an error occurs, record the first operating voltage as an erroneous operating voltage, and if the error does not occur, provide a second operating voltage to the image processing chip. Also, when the written second image data is read from the storage device, the test device receives a second error detection code corresponding to the second image data and determines whether the second error detection code means an error occurs.

Abstract: An image processing chip test method comprising: controlling a power supply circuit to provide a first operating voltage to an image processing chip comprising a storage device; and when reading written first image data from the storage device, the test device receives a first error detection code corresponding to the first image data and determines whether the first error detection code means an error occurs. If an error occurs, record the first operating voltage as an erroneous operating voltage, and if the error does not occur, provide a second operating voltage to the image processing chip. Also, when the written second image data is read from the storage device, the test device receives a second error detection code corresponding to the second image data and determines whether the second error detection code means an error occurs.

Abstract: A system and method for engineering loss in a physical system by steering parameters of the physical system to the vicinity of an exceptional point is disclosed. In the vicinity of an exceptional point, localization of the fields helps to enhance any linear or nonlinear processes. As examples loss-induced transparency in the intracavity field intensities of coupled resonators, loss-induced suppression and enhancement of thermal nonlinearity in coupled resonators and loss-induced suppression and revival of Raman lasing in whispering-gallery-microcavities are demonstrated.

Abstract: Disclosed is an LTE-V based Internet of Vehicles communication test system and test method. The test system includes an ENodeB base station, a roadside test unit, user test terminal, LTE-V core network and local server group. Mobile communication technology is applied to the field of Internet of Vehicles communication, and two technical schemes are used, i.e., wide-area centralized cellular communication and short-range distributed direct communication corresponding to the network architectures based on access network-user terminal and ProSe direct communication interface, respectively. Not only the communication transmission support with large broadband in wide coverage can be supported, but also to achieve low latency and highly reliable communication services between vehicle and vehicle, vehicle and base station, base station and base station, to meet the needs of road safety and traffic efficiency applications.

Abstract: Provided are a system and a method for testing an ability of an automated vehicle to pass a traffic circle without traffic lights. The system includes an automated vehicle, a traffic circle, a control center, an attitude sensor and a panorama camera. In the method, the control center receives a test request and then sends a driving command to drive the automated vehicle to enter the traffic circle to start the test. The attitude sensor obtains a tilt angle and sends it to the control center in real time. The panorama camera is configured to obtain a driving trajectory, a driving speed and a state of turn signals of the automated vehicle. The obtained information is compared to a standard by the control center to evaluate the ability of the automated vehicle to pass the traffic circle without traffic lights.

Abstract: Provided herein relates to the performance testing of automated vehicles, and more particularly to a system and a method for testing cooperative driving capability of an automated vehicle. The system includes a target vehicle, a test road and a control center, where the automated vehicle and the target vehicle are located on the test road, and the control center is located beside the test road. A speed sensor and a binocular camera are provided on the automated vehicle. The speed sensor and the binocular camera are connected to the control center through a wireless communication device, respectively. An on-board device is provided on the target vehicle and is connected to the control center through the wireless communication device. The method provided herein is used to determine the responsiveness of automated vehicles according to the speed relationship and distance between the automated vehicle and the target vehicle.