Abstract: The invention refers to a reactor and a method respectively for performing, by means of solid reaction members, a biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic media, and a subsequent cleaning of the reactor, said reactor comprising a vessel (11) in which a transformation device (100) has been mounted. The invention also refers to a reactor kit comprising such reactor. The reactor comprises at least one nozzle (15) arranged on the longitudinal inner wall of the vessel (11). The at least one nozzle (15) is arranged to direct a flow of a cleaning fluid (CF) in a direction towards a longitudinal centre axis (L1) of a flow distributor (1) arranged in the vessel (11).

Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.

Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.

Abstract: The invention refers to a reactor and a method respectively for performing, by means of solid reaction members, a biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic media, and a subsequent cleaning of the reactor, said reactor comprising a vessel (11) in which a transformation device (100) has been mounted. The invention also refers to a reactor kit comprising such reactor. The reactor comprises at least one nozzle (15) arranged on the longitudinal inner wall of the vessel (11). The at least one nozzle (15) is arranged to direct a flow of a cleaning fluid (CF) in a direction towards a longitudinal centre axis (L1) of a flow distributor (1) arranged in the vessel (11).

Abstract: The present invention relates to the field of biological and chemical transformation as well as physical and chemical trapping. More specifically, the invention relates to a new reactor arrangement for performing, by means of at least one solid reaction member, biological or chemical transformation, or physical or chemical trapping from or release of agents to, a fluidic medium. The reactor arrangement is comprised of an auxiliary reactor having a transformation device and a main reactor. The invention also provides an auxiliary reactor adapted for being connected to a main reactor, a method of using such a reactor arrangement, as well as a process involving the reactor arrangement.

Abstract: There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.

Abstract: There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.

Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.

Abstract: The present invention relates to the field of biological and chemical transformation as well as physical and chemical trapping. More specifically, the invention relates to a new reactor arrangement for performing, by means of at least one solid reaction member, biological or chemical transformation, or physical or chemical trapping from or release of agents to, a fluidic medium. The reactor arrangement is comprised of an auxiliary reactor having a transformation device and a main reactor. The invention also provides an auxiliary reactor adapted for being connected to a main reactor, a method of using such a reactor arrangement, as well as a process involving the reactor arrangement.

Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.

Abstract: There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).

Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.

Abstract: There is provided a process for the preparation of a compound of formula II, wherein R1, R2, R3 and R4 are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.

Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.

Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.

Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.

Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. Intermediate steps of the process comprise formulae according to (II) and (III).

Abstract: There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).

Abstract: There is provided a process for the preparation of a compound of formula II, wherein R1, R2, R3 and R4 are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.

Abstract: The present invention relates to a microwave apparatus, a method or use of the apparatus and a method of carrying out chemical reactions on a continuous basis with the apparatus, wherein the apparatus is particularly suitable for microwave-assisted organic synthesis.