Patents by Inventor Lars Goran Wistrand
Lars Goran Wistrand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8815210Abstract: The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions.Type: GrantFiled: October 28, 2010Date of Patent: August 26, 2014Assignee: GE Healthcare ASInventors: Lars-Göran Wistrand, Mikkel Thaning, Ben Newton
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Publication number: 20120328522Abstract: The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions.Type: ApplicationFiled: October 28, 2010Publication date: December 27, 2012Inventors: Lars-Göran Wistrand, Mikkel Thaning, Ben Newton
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Patent number: 8003077Abstract: The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.Type: GrantFiled: October 24, 2003Date of Patent: August 23, 2011Assignee: GE Healthcare ASInventors: Jan-Henrik Ardenkjaer-Larsen, Lennart Hansson, Haukur Johannesson, Rolf Servin, Lars-Goran Wistrand
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Publication number: 20110017673Abstract: This invention relates to the manufacture of contrast media, and more specifically to the removal of endotoxins in such contrast media.Type: ApplicationFiled: October 21, 2009Publication date: January 27, 2011Applicant: GE HEALTHCARE ASInventors: GUNNAR HAGELIN, LARS GORAN WISTRAND
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Publication number: 20100221192Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula and salts or optical active isomers thereof, wherein each of R1, R2 and R3 independently are the same or different and denote a hydrogen atom or a C1 to C4 straight of branched alkyl group; each R4 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by up to 6 —OH groups; and each R5 independently are the same or different and denote C1 to C6 straight or branched alkyl moieties substituted by up to 6 —OH groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: ApplicationFiled: October 10, 2008Publication date: September 2, 2010Inventors: Duncan George Wynn, Lars-Goran Wistrand
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Publication number: 20100209356Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I) and salts or optical active isomers thereof, wherein each of R1, R2 and R3 independently are the same or different and denote a hydrogen atom or a C1 to C4 straight of branched alkyl group; each R4 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by up to 6 —OH groups; and each R5 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by up to 6 —OH groups provided that at least one alkyl group is substituted with at least 2 hydroxy groups.Type: ApplicationFiled: October 10, 2008Publication date: August 19, 2010Inventors: Duncan George Wynn, Lars-Goran Wistrand
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Publication number: 20100189656Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a triamine alkyl central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: June 27, 2008Publication date: July 29, 2010Inventors: Lars-Goran Wistrand, Duncan George Wynn, Ian Martin Newington, Veronique Morisson-Iveson
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Publication number: 20100183522Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a tris(aminoalkyl)amine group allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: June 27, 2008Publication date: July 22, 2010Inventors: Lars-Goran Wistrand, Duncan George Wynn, Ian Martin Newington
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Patent number: 7485753Abstract: The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: GrantFiled: December 1, 2006Date of Patent: February 3, 2009Assignee: GE Healthcare ASInventors: Lars-Goran Wistrand, Mikkel Thaning, Oskar Axelsson, Sven Andersson
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Publication number: 20080199402Abstract: The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: December 1, 2006Publication date: August 21, 2008Inventors: Lars-Goran Wistrand, Mikkel Thaning, Oskar Axelsson, Sven Andersson
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Publication number: 20070148096Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a benzene scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: December 14, 2006Publication date: June 28, 2007Inventors: Lars-Goran Wistrand, Mikkel Thaning, Oskar Axelsson, Sven Andersson
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Publication number: 20060199272Abstract: The present invention relates to radicalas for use in a dynamic nuclear polarisation (DNP) of a sample. The invention further relates to a dynamic nuclear polarisation of a mixture comprising these radicals.Type: ApplicationFiled: April 15, 2004Publication date: September 7, 2006Inventor: Lars-Goran WISTRAND
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Publication number: 20060173282Abstract: The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.Type: ApplicationFiled: October 24, 2003Publication date: August 3, 2006Inventors: Jan-Henrik Ardenkjaer-Larsen, Lennart Hansson, Haukur Johannesson, Rolf Servin, Lars-Goran Wistrand
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Patent number: 6466814Abstract: The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T1 agent. The polarizing agent is optionally separated from the high T1 agent before the high T1 agent is administered to the sample.Type: GrantFiled: June 30, 2000Date of Patent: October 15, 2002Assignee: Amersham Health ASInventors: Jan Henrik Ardenkjaer-Larsen, Oskar Axelsson, Klaes Golman, Lars-Goran Wistrand, Georg Hansson, Ib Leunbach, Stefan Petersson
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Patent number: 6453188Abstract: The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.Type: GrantFiled: June 16, 1999Date of Patent: September 17, 2002Assignee: Amersham Health ASInventors: Jan Henrik Ardenkjaer-Larsen, Oskar Axelsson, Klaes Golman, Georg Hansson, Ib Leunbach, Stefan Petersson, Lars-Goran Wistrand
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Patent number: 6391895Abstract: Chelating agents, in particular dipyridoxyl and aminopolycarboxylic acid based chelating agents, and their metal chelates, when linked directly or indirectly to at least one nitric oxide releasing moiety, or when use in combination with nitric oxide or a nitric oxide releasing moiety have been found to be effective in treating a variety of disorders. In particular, such compounds may be used in treating conditions associated with the presence of free radicals in the body, e.g. reperfusion injuries, and in reducing the cardiotoxicity of anti-tumor agents, e.g. anthracyclines and/or paclitaxel.Type: GrantFiled: June 23, 2000Date of Patent: May 21, 2002Assignee: Amersham Health ASInventors: Robertson Towart, Jan Olof Gustav Karlsson, Lars Goran Wistrand, Hakan Malmgren
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Patent number: 6311086Abstract: This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.Type: GrantFiled: December 13, 1999Date of Patent: October 30, 2001Assignee: Nycomed Imaging ASInventors: Jan Henrik Ardenkjaer-Larsen, Klaes Golman, Georg Hansson, Ib Leunbach, Stefan Petersson, Lars-Goran Wistrand, Oskar Axelsson
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Patent number: 6310243Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6R6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20° C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20° C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.Type: GrantFiled: December 22, 1998Date of Patent: October 30, 2001Assignee: Nycomed Imaging ASInventors: Torsten Almen, Sven Andersson, Lars-Goran Wistrand, Klaes Golman, Oyvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, Hakan Wikstrom, Tomas Klingstedt, Ib Luenbach, Arne Berg, Harald Dugstad
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Patent number: 6284894Abstract: A process for the preparation of an allylic aromatic compound in which an aromatic amine is reacted first with a nitrite and then with an allylic olefin having an eliminatable terminal substituent. Novel allylic derivatives of disubstituted benzene compounds are also described.Type: GrantFiled: December 17, 1999Date of Patent: September 4, 2001Assignee: Nycomed Imaging ASInventors: Fredrik Ek, Lars Goran Wistrand
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Patent number: 6278893Abstract: The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T1 agent and wherein the polarising agent is optionally seperated from the high T1 agent before the high T1 agent is administered to the sample.Type: GrantFiled: October 9, 1998Date of Patent: August 21, 2001Assignee: Nycomed Imaging ASInventors: Jan Henrik Ardenkjær-Larson, Oskar Axelsson, Klaes Golman, Georg Hansson, Ib Leunbach, Stefan Petersson, Lars-Göran Wistrand