Patents by Inventor Lars Goran Wistrand
Lars Goran Wistrand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6063360Abstract: The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.Type: GrantFiled: March 6, 1998Date of Patent: May 16, 2000Assignee: Nycomed Imaging A/SInventors: Sven Andersson, Finn Radner, Anna Rydbeck, Rolf Servin, Lars-Goran Wistrand, Mikkel Thaning
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Patent number: 6008644Abstract: This invention relates to a method of electron spin resonance enhanced magnetic resonance imaging which relies on ex vivo dynamic nuclear polarisation of an MR imaging agent.Type: GrantFiled: July 3, 1997Date of Patent: December 28, 1999Assignees: Picker Nordstar OY, Nycomed Imaging ASInventors: Ib Leunbach, Ian Young, Gosta Ehnholm, Georg Hansson, Stefan Petersson, Lars-Goran Wistrand, Klaes Golman
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Patent number: 5993780Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.Type: GrantFiled: March 24, 1997Date of Patent: November 30, 1999Assignee: Nycomed Imaging ASInventors: Torsten Almen, Sven Goran Andersson, Lars-Goran Wistrand, Klaes Golman, .O slashed.yvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, H.ang.kan Wikstrom, Tomas Klingstedt, Ib Leunbach, Arne Berg, Harald Dugstad
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Patent number: 5958376Abstract: The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C.sub.6 R.sub.5 moiety may be the same or different; each denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C.sub.6 R.sub.5 moiety denoting iodine atoms and one, two or three R groups on each C.sub.6 R.sub.5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C.sub.6 R.sub.5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C.sub.6 R.sub.5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.Type: GrantFiled: June 27, 1997Date of Patent: September 28, 1999Assignee: Nycomed Imaging ASInventors: Anna Rydbeck, Torsten Almen, Mikkel Thaning, Sven Goran Andersson, Lars-Goran Wistrand, Klaes Golman
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Patent number: 5958375Abstract: The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein each C.sub.6 R.sub.5 moeity may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C.sub.6 R.sub.5 moiety denoting iodine atoms and one, two or three R groups on each C.sub.6 R.sub.5 moiety denoting M groups;X denotes a group providing a 1, 2 or 3 atom chain linking the two C.sub.6 R.sub.5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C.sub.6 R.sub.5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.Type: GrantFiled: June 6, 1995Date of Patent: September 28, 1999Assignee: Nycomed Imaging ASInventors: Anna Rydeck, Torsten Almen, Mikkel Thaning, Sven Andersson, Lars-Goran Wistrand, Klaes Golman
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Patent number: 5882628Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.Type: GrantFiled: June 6, 1995Date of Patent: March 16, 1999Assignee: Nycomed Imaging ASInventors: Torsten Almen, Sven Andersson, Lars-Goran Wistrand, Klaes Golman, Oyvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, Hakan Wikstrom, Tomas Klingstedt, Ib Luenbach, Arne Berg, Harald Dugstad
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Patent number: 5827501Abstract: The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.Type: GrantFiled: June 7, 1995Date of Patent: October 27, 1998Assignee: Nycomed Imaging ASInventors: Mikkel J.o slashed.rgensen, Frode Rise, Sven Andersson, Torsten Almen, Arne Aabye, Lars-Goran Wistrand, H.ang.kan Wikstrom, Klaes Golman, Rolf Servin, Peter Michelsen
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Patent number: 5728370Abstract: The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.Type: GrantFiled: June 6, 1995Date of Patent: March 17, 1998Assignee: Nycomed Imaging ASInventors: Sven Andersson, Finn Radner, Anna Rydbeck, Rolf Servin, Lars-Goran Wistrand
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Patent number: 5700448Abstract: The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.Type: GrantFiled: April 3, 1995Date of Patent: December 23, 1997Assignee: Nycomed Imaging ASInventors: Klaes Golman, Sven Andersson, Frode Rise, Lars-Goran Wistrand, Hakan Wikstrom
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Patent number: 5530140Abstract: The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.Type: GrantFiled: March 31, 1994Date of Patent: June 25, 1996Assignee: Nycomed Imaging ASInventors: Sven Andersson, Finn Radner, Anna Rydbeek, Rolf Servin, Lars-Goran Wistrand
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Patent number: 5435991Abstract: The present invention provides the use of a persistent .pi.-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising .pi.-system of said radical comprises at least one homo or heterocyclic ring, said radical being other than the chloranil semiquinone anion radical or a trityl radical. Also provided are magnetic resonance imaging contrast media containing and methods using such radicals.Type: GrantFiled: March 18, 1994Date of Patent: July 25, 1995Assignee: Nycomed Innovation ABInventors: Klaes Golman, Sven Andersson, Frode Rise, Lars-Goran Wistrand, Hakan Wikstrom