Abstract: There is provided herein compounds of formula I: (I) and pharmaceutically-acceptable salts and/or detectably-labelled derivatives thereof, wherein RA, RB, X, Y, n and m have meanings as provided in the description, together with formulations and products comprising the same. There is also provided the use of such compounds, formulations and products in the treatment of cancers, such as cancers characterised by increased MYC activity.

Abstract: A marine propeller combination for a marine propulsion unit includes a first propeller and a second propeller arranged to rotate simultaneously in opposite directions about a common rotational axis. The marine propeller combination is configured such that the first and second propellers are angularly positioned such that during one revolution one of the blades of the first propeller is aligned with a drive leg of the marine propulsion unit when a blade gap of the second propeller is aligned with the drive leg, or one of the blades of the first propeller is aligned with the drive leg when one of the blades of the second propeller is aligned with the drive leg. The disclosure further relates to a marine vessel and to a method of operating a marine propeller combination.

Abstract: A computer-implemented method for maneuvering a boat provided with a single drive unit, includes: Obtaining net momentum direction data indicative of a target horizontal rotational movement of the hull, triggering a series of bursts of thrust by the drive unit, said series of bursts of thrust comprising a plurality of primary bursts and a plurality of secondary bursts directed differently than the primary bursts, The primary bursts and the secondary bursts are directed such that they provide a respective longitudinal thrust component parallel to a hull longitudinal axis. The primary bursts are directed such that the longitudinal thrust components of the primary bursts act in the opposite direction with respect to the direction of the longitudinal thrust components of the secondary bursts. The primary bursts and the secondary bursts are further directed such that they jointly provide a net momentum on the hull associated with said net momentum direction data.

Abstract: The present disclosure relates to a vehicle (100) comprising at least a towing vehicle (102), the towing vehicle comprising steerable wheels and is arranged to convey the vehicle in at least a major longitudinal forward direction (104) of the vehicle (100), wherein the vehicle further comprises a load handling arrangement (200) arranged to support transportation of material to or from the vehicle (100), the load handling arrangement (200) being configured to assume a material handling mode in which the load handling arrangement (200) is arranged to support transportation of the material between the vehicle (100) and a stationary ground portion (106) in the vicinity of the vehicle (100), wherein the load handling arrangement (200) extends substantially in the major longitudinal forward direction (104) of the vehicle over at least a portion of the towing vehicle (102) when assuming the material handling mode.

Abstract: A method of controlling a propeller drive assembly attachable to a hull of a marine vessel, said propeller drive assembly comprising a propeller drive unit and a housing for attachment to a hull of the marine vessel on an inside of the hull. The housing defines an inner space and an opening through which at least a portion of the propeller drive unit is movable into and out of the inner space. The propeller drive assembly comprises a suspension mechanism attached to the housing and configured to suspend the propeller drive unit, wherein the suspension mechanism is adapted to move the propeller drive unit between a stowed position and a deployed position.

Abstract: The present disclosure relates to a method for controlling a driveline of a vehicle, the driveline being operable in a plurality of driveline operating modes, wherein the driveline is configured to assume a current driveline operating mode basing its operation on topology data from a positioning system, each driveline operating mode being associated with a predefined driveline operating condition, wherein the method comprises obtaining a signal indicative of a loss of topology data; and controlling the driveline to change from the current driveline operating mode to an updated driveline operating mode providing an increased operational capacity of the driveline compared to the current driveline operating mode.

Abstract: There is herein provided a compound of formula I or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A1, A2, L1, R1, R2 and n have meanings as provided in the description.

Abstract: A marine propulsion system includes wings with a hydrofoil shaped geometry arranged for mounting on opposite side sections of a vessel comprising at least one hull adjacent the transom. Each wing includes a first section extending downwards along the side of the hull and at least partially below the waterline in its operative position. Each wing includes a second section extending towards the central longitudinal axis of the hull in its operative position. The second section each wing is arranged to support at least one propulsor. The first section of each wing is mounted rotatable about a vertical axis.

Abstract: The present invention relates to a twistlock assembly for securing a cargo member to a cargo receiving arrangement. The twistlock assembly comprises a twistlock and a base member. The twistlock is adapted to be at least partially inserted into an opening of a cargo member. The twistlock is adapted to assume each one of an unlocked position and a locked position, wherein the cargo member is prevented from being disconnected from the base member when the twistlock assumes the locked position.

Abstract: The present invention relates to the use of CDK8 and/or CDK19 inhibitors in the treatment of ribosomopathies as well as conditions characterized by reduced number of hematopoietic stem cells and/or progenitor cells; and bone anabolic disorders.

Abstract: A fifth wheel control arrangement (100) for an articulated vehicle comprising a fifth wheel having a biased hinge joint and an actuator (115) arranged to control a biasing force and/or a damping force of the biased hinge joint. The control arrangement comprises a control unit configured to automatically control the actuator in response to one or more input sensor signals associated with a current state of the articulated vehicle, to obtain a target wheel axle load of the articulated vehicle and/or to stabilize the articulated vehicle.

Abstract: The present disclosure relates to a vehicle (100) comprising at least a towing vehicle (102), the towing vehicle comprising steerable wheels and is arranged to convey the vehicle in at least a major longitudinal forward direction (104) of the vehicle (100), wherein the vehicle further comprises a load handling arrangement (200) arranged to support transportation of material to or from the vehicle (100), the load handling arrangement (200) being configured to assume a material handling mode in which the load handling arrangement (200) is arranged to support transportation of the material between the vehicle (100) and a stationary ground portion (106) in the vicinity of the vehicle (100), wherein the load handling arrangement (200) extends substantially in the major longitudinal forward direction (104) of the vehicle over at least a portion of the towing vehicle (102) when assuming the material handling mode.

Abstract: There is herein provided a compound of formula I or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A1, A2, L1, R1, R2 and n have meanings as provided in the description.

Abstract: There is herein provided a compound of formula I (I) or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A1, A2, L1, R1, R2 and n have meanings as provided in the description.

Abstract: There is herein provided a compound of formula I (I) or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A1, A2, L1, R1, R2 and n have meanings as provided in the description.

Abstract: The present invention relates to the use of CDK8 and/or CDK19 inhibitors in the treatment of ribosomopathies as well as conditions characterized by reduced number of hematopoietic stem cells and/or progenitor cells; and bone anabolic disorders.

Abstract: A grounding attachment for grounding an outer wall of a pole (13) made of a metal sheet covered on both sides by a coating layer of an electrically insulating material comprises a base element (1) of metal configured to be applied to bear on an inner wall of a pole in a state of use of the grounding attachment and at least one member (8, 9) of metal projecting from the base element and configured to be introduced into a hole in a wall of a pole in the state of use and to bear onto portions of the metal sheet defining the hole so as to establish an electrical contact thereto. The base element is provided with a connector member (4) enabling connection of the base element and by that the pole to ground.

Abstract: A method, performed by a base station (100) in a GSM/EDGE Radio Access Network, GERAN, of providing traffic classification for a data traffic flow, related to a General Packet Radio Service, GPRS, or Enhanced General Packet Radio Service, EGPRS. The method comprises the step of the base station (100) obtaining (S1), for the data traffic flow, a traffic-class-based network layer Quality of Service, QoS, attribute for traffic prioritization. The method also comprises the step of the base station (100) including (S2) the traffic-class-based network layer QoS attribute in data packets of the data traffic flow to provide network-layer traffic classification for the data traffic flow.

Abstract: A pole arrangement comprising: —a pole (2) with a tubular external wall (4) of sheet metal; —a foundation (5) with a cavity (7) for receiving a lower section (8) of the external wall (4) of the pole; —a wedge element (6) for securing the pole in the cavity by wedging; and —a reinforcement element (23) mounted to a part of the section (8) of the external wall (4) of the pole received in the cavity, in order to counteract buckling of this part. The wedge element bears against the external wall of the pole through supporting projections, wherein there are free spaces between the supporting projections in order to allow parts of the external wall of the pole to be pressed into some of these spaces when the external is buckled in connection with a collision.