Patents by Inventor Lars Otto Uttenthal

Lars Otto Uttenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for preventing and treating pulmonary injury due to ionizing radiation or cytotoxic drugs
    Patent number: 11903925
    Abstract: Compositions comprising melatonin or derivatives thereof for administration to the epithelium of the lower airway to protect against lung damage due to chest irradiation and/or cytotoxic chemotherapy are provided.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: February 20, 2024
    Assignee: RepoCeuticals A/S
    Inventor: Lars Otto Uttenthal
  • COMPOSITIONS FOR TREATING GASTROINTESTINAL ADENOCARCINOMAS BY ALTERING THE TUMOR MICROENVIRONMENT
    Publication number: 20240033342
    Abstract: The present invention provides compositions comprising a vaccine against the SARS-CoV-2 virus for promoting an antitumor immune response in a subject with an accessible adenocarcinoma tumor who has previously been exposed to said virus by infection or vaccination, by the direct injection of the composition into the tumor.
    Type: Application
    Filed: August 12, 2021
    Publication date: February 1, 2024
    Inventors: Lars Otto Uttenthal, Torsten Bjørn
  • COMPOSITIONS FOR ALLEVIATING THE SYMPTOMS OF LOW ANTERIOR RESECTION SYNDROME BY TOPICAL ADMINISTRATION TO THE NEORECTUM
    Publication number: 20230057930
    Abstract: Compositions comprising melatonin and dimethyl sulfoxide are provided for topical administration to the neorectum for use in the alleviation of the symptoms of low anterior resection syndrome.
    Type: Application
    Filed: January 14, 2021
    Publication date: February 23, 2023
    Inventors: Lars Otto Uttenthal, Lasse Lindblad
  • Compositions for the prevention and treatment of acute renal injury
    Patent number: 11471445
    Abstract: Pharmaceutical compositions are provided for the treatment, pre-emptive treatment or prevention of acute renal injury.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: October 18, 2022
    Assignee: AKI Therapeutics ApS
    Inventor: Lars Otto Uttenthal
  • COMPOSITIONS TO PROMOTE THE HEALING OF SKIN ULCERS AND WOUNDS
    Publication number: 20220218792
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of wounds, ulcers, sores, burns and other injuries to the skin or mucous membranes of the body.
    Type: Application
    Filed: August 20, 2021
    Publication date: July 14, 2022
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITION FOR THE INTRAPERITONEAL TREATMENT OF SECONDARY BACTERIAL PERITONITIS WITH REDUCTION OF COMPLICATIONS
    Publication number: 20220211667
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antibiotic agents to treat, pre-emptively treat or prevent infectious peritonitis or intra-abdominal infection and reduce the occurrence of local peritonitis or intra-abdominal abscess resulting therefrom by the intraperitoneal administration of the compositions.
    Type: Application
    Filed: April 23, 2020
    Publication date: July 7, 2022
    Inventors: Lars Otto Uttenthal, Torsten Bjørn
  • TARGETING BIOLOGICAL AGENTS TO MUCOSAL DEFECTS OF THE GASTROINTESTINAL TRACT
    Publication number: 20220175885
    Abstract: Compositions are provided that target biological therapeutic agents to mucosal defects in the gastrointestinal tract by means of antacid mucosal protective agents that bind selectively to such defects.
    Type: Application
    Filed: March 19, 2020
    Publication date: June 9, 2022
    Inventors: Lars Otto Uttenthal, Lasse Lindblad
  • COMPOSITIONS FOR RETARDING THE DECOMPOSITION OF MELATONIN IN SOLUTION
    Publication number: 20220168425
    Abstract: Use of dimethyl sulfoxide (DMSO) or glycofurol or their combination as an additive in a solution comprising a solvent and at least one active ingredient selected from melatonin and/or an antioxidant metabolite, derivative or analogue thereof, for prolonging stability and/or shelf life of said at least one active ingredient in said solution by retarding a decomposition of said at least one active ingredient comprised in said solution.
    Type: Application
    Filed: December 7, 2021
    Publication date: June 2, 2022
    Inventors: Lars Otto Uttenthal, Lasse Lindblad
  • COMPOSITIONS FOR USE IN THE TREATMENT OF PHOTOSENSITIVITY
    Publication number: 20220016006
    Abstract: Compositions comprising melatonin and/or derivatives thereof for topical application to the skin for use in the treatment of photosensitivity of whatever cause are described.
    Type: Application
    Filed: December 4, 2019
    Publication date: January 20, 2022
    Inventors: Lars Otto Uttenthal, Torsten Bjørn
  • COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ACUTE RENAL INJURY
    Publication number: 20210330649
    Abstract: Pharmaceutical compositions are provided for the treatment, pre-emptive treatment or prevention of acute renal injury.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 28, 2021
    Inventor: Lars Otto Uttenthal
  • Methods and devices for rapid assessment of severity of injury
    Patent number: 11125761
    Abstract: Methods and devices for rapid assessment of the severity of injury not due to a natural disease based upon measurement of neutrophil gelatinase-associated lipocalin (NGAL) are provided.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: September 21, 2021
    Assignee: Antibodyshop A/S
    Inventors: Kristian Bangert, Lars Otto Uttenthal
  • MELATONIN FOR PREVENTING AND TREATING RADIATION VAGINITIS AND PROCTITIS
    Publication number: 20210267942
    Abstract: Compositions comprising melatonin or derivatives thereof are provided for topical administration to the vaginal and/or rectal epithelium to protect against vaginal and/or rectal radiation injury due to radiotherapy.
    Type: Application
    Filed: October 22, 2020
    Publication date: September 2, 2021
    Inventor: Lars Otto Uttenthal
  • COMPOSITIONS FOR TREATING LUNG INFECTIONS BY AIRWAY ADMINISTRATION
    Publication number: 20210121528
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of bacterial lung infections by administration via the air-ways.
    Type: Application
    Filed: June 9, 2020
    Publication date: April 29, 2021
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS FOR ELIMINATING BACTERIAL PROMOTORS OF COLORECTAL CANCER BY INTRALUMINAL APPLICATION
    Publication number: 20210060038
    Abstract: The present invention provides compositions comprising fosfomycin for reducing or eliminating bacterial promotors of colorectal cancer, whether in the tumor or biofilm, by local administration into the bowel lumen.
    Type: Application
    Filed: January 14, 2019
    Publication date: March 4, 2021
    Inventors: Lars Otto Uttenthal, Torsten Bjørn
  • COMPOSITIONS TO PROMOTE THE HEALING OF SKIN ULCERS AND WOUNDS
    Publication number: 20200254062
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of wounds, ulcers, sores, burns and other injuries to the skin or mucous membranes of the body.
    Type: Application
    Filed: October 8, 2019
    Publication date: August 13, 2020
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • Methods for inhibiting infectious peritonitis
    Patent number: 10716831
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antimicrobial agents for the treatment, pre-emptive treatment or prevention of infectious peritonitis or intra-abdominal infection by intraperitoneal administration of the compositions.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 21, 2020
    Assignee: REPONEX PHARMACEUTICALS A/S
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • Melatonin for Preventing and Treating Radiation Cystitis
    Publication number: 20200197367
    Abstract: Compositions comprising melatonin and/or derivatives thereof are provided for topical administration to the epithelium of the urinary bladder by instillation into the bladder to protect against or treat bladder injury due to irradiation and/or cytotoxic agents.
    Type: Application
    Filed: March 11, 2019
    Publication date: June 25, 2020
    Inventors: Lasse Lindblad, Lars Otto Uttenthal
  • COMPOSITIONS FOR RETARDING THE DECOMPOSITION OF MELATONIN IN SOLUTION
    Publication number: 20200030450
    Abstract: Use of dimethyl sulfoxide (DMSO) or glycofurol or their combination as an additive in a solution comprising a solvent and at least one active ingredient selected from melatonin and/or an antioxidant metabolite, derivative or analogue thereof, for prolonging stability and/or shelf life of said at least one active ingredient in said solution by retarding a decomposition of said at least one active ingredient comprised in said solution.
    Type: Application
    Filed: March 16, 2018
    Publication date: January 30, 2020
    Inventors: Lars Otto Uttenthal, Lasse Lindblad
  • Compositions for Preventing and Treating Pulmonary Injury due to Ionizing Radiation or Cytotoxic Drugs
    Publication number: 20190282545
    Abstract: Compositions comprising melatonin or derivatives thereof for administration to the epithelium of the lower airway to protect against lung damage due to chest irradiation and/or cytotoxic chemotherapy are provided.
    Type: Application
    Filed: October 16, 2018
    Publication date: September 19, 2019
    Inventor: Lars Otto Uttenthal
  • COMPOSITIONS FOR THE TREATMENT OF PERITONITIS
    Publication number: 20190275107
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antimicrobial agents for the treatment, pre-emptive treatment or prevention of infectious peritonitis or intra-abdominal infection by intraperitoneal administration of the compositions.
    Type: Application
    Filed: October 18, 2018
    Publication date: September 12, 2019
    Inventors: Lars Heslet, Lars Otto Uttenthal