Abstract: An improved article of footwear of the invention includes an upper, an adjustable closure system affixed to the upper, the closure system having a guide member having a first groove portion and a second groove portion, a fastening member positioned opposite the guide member and having at least two tensioning members, and removable cable assembly connecting the guide member and the fastening member, wherein the cable assembly extends sequentially through the first groove portion of the guide member, a first tensioning member of the fastening member, the second groove portion of the guide member, and a second tensioning member of the fastening member, a bottom secured to the upper, a stabilizing member positioned between the upper and the bottom, wherein the stabilizing member has a base portion and at least one of a lateral support portion and a medial support portion extending upwardly from opposing sides of the base portion.

Abstract: Provided herein are vectors comprising a polycistronic expression casstte comprising a polynucleotide that encodes a CD 19 specific chimeric antigen receptor, a polynucleotide that encodes a cytokine, and a polynucleotide that encodes a marker protein, wherein the polynucleotide that encodes the CD 19-specific chimeric antigen receptor and the polynucleotide that encodes the cytokine coding sequence are separated by a polynucleotide sequence that comprises an F2A element, and wherein the polynucleotide sequence that encodes the cytokine and the polynucleotide sequence that encodes the marker protein are separated by a polynucleotide sequence that comprises a T2A element.

Abstract: Systems, methods, computer-readable medium, vehicles, and engines provided herein include or implement flexible engine monitoring features. In one aspect, a user-modifiable file containing selected parameters is uploaded to a vehicle having a propulsion system, such as an engine. A computing device associated with the engine generates, without modifying reporting software or any other software, a parameter reporting list that includes the selected parameters. During operation, parameter values for the selected parameters are recorded. In another aspect, a data query is transmitted to an aerial vehicle while in-flight. The data query includes a user-modifiable file that contains selected parameters for which parameter values are to be recorded. A computing device associated with the engine generates, without modifying reporting software or any other software, a parameter reporting list that includes the selected parameters.

Abstract: Provided herein are vectors comprising a polycistronic expression casstte comprising a polynucleotide that encodes a TCR alpha chain, a polynucleotide that encodes a TCR beta chain, and a polynucleotide that encodes a cytokine, wherein the polynucleotides are separated by polynucleotide sequences that comprise 2A elements.

Abstract: The present invention provides methods of treating glioblastoma by administering an adenoviral vector that conditionally expresses IL-12 via gene switch under control of an oral activator ligand.

Abstract: A method, system, and computer program product for enabling a digital search is provided. The method includes monitoring, in response to receiving authorization from a user, Web search results of a user, social media accounts, and media sources. In response data indicating an importance of world related factors with respect to the user is received. The data is analyzed with respect to results of the monitoring and an associated metadata model and modeling software application personalized for the user is generated. A search request associated with initiating a Web search for a product or service is initiated and the modeling software application is executed with respect to the metadata model and Web search. Personalized Web search results are generated and presented to the user. The personalized Web search results indicate entities associated with providing the product or service for the user via Internet based commerce Websites.

Abstract: An improved article of footwear of the invention includes an upper, an adjustable closure system affixed to the upper, the closure system having a guide member having a first groove portion and a second groove portion, a fastening member positioned opposite the guide member and having at least two tensioning members, and removable cable assembly connecting the guide member and the fastening member, wherein the cable assembly extends sequentially through the first groove portion of the guide member, a first tensioning member of the fastening member, the second groove portion of the guide member, and a second tensioning member of the fastening member, a bottom secured to the upper, a stabilizing member positioned between the upper and the bottom, wherein the stabilizing member has a base portion and at least one of a lateral support portion and a medial support portion extending upwardly from opposing sides of the base portion.

Abstract: A method, system, and computer program product for enabling a digital search is provided. The method includes monitoring, in response to receiving authorization from a user, Web search results of a user, social media accounts, and media sources. In response data indicating an importance of world related factors with respect to the user is received. The data is analyzed with respect to results of the monitoring and an associated metadata model and modeling software application personalized for the user is generated. A search request associated with initiating a Web search for a product or service is initiated and the modeling software application is executed with respect to the metadata model and Web search. Personalized Web search results are generated and presented to the user. The personalized Web search results indicate entities associated with providing the product or service for the user via Internet based commerce Websites.

Abstract: Systems, methods, computer-readable medium, vehicles, and engines provided herein include or implement flexible engine monitoring features. In one aspect, a user-modifiable file containing selected parameters is uploaded to a vehicle having a propulsion system, such as an engine. A computing device associated with the engine generates, without modifying reporting software or any other software, a parameter reporting list that includes the selected parameters. During operation, parameter values for the selected parameters are recorded. In another aspect, a data query is transmitted to an aerial vehicle while in-flight. The data query includes a user-modifiable file that contains selected parameters for which parameter values are to be recorded. A computing device associated with the engine generates, without modifying reporting software or any other software, a parameter reporting list that includes the selected parameters.

Abstract: An improved article of footwear of the invention includes an upper, an adjustable closure system affixed to the upper, the closure system having a guide member having a first groove portion and a second groove portion, a fastening member positioned opposite the guide member and having at least two tensioning members, and removable cable assembly connecting the guide member and the fastening member, wherein the cable assembly extends sequentially through the first groove portion of the guide member, a first tensioning member of the fastening member, the second groove portion of the guide member, and a second tensioning member of the fastening member, a bottom secured to the upper, a stabilizing member positioned between the upper and the bottom, wherein the stabilizing member has a base portion and at least one of a lateral support portion and a medial support portion extending upwardly from opposing sides of the base portion.

Abstract: A method of attaching an adapter to a polynucleotide comprising: providing a double stranded polynucleotide comprising a single stranded break point within its polynucleotide sequence; contacting said double stranded polynucleotide with an exonuclease to form a single stranded region initiated at said break point; attaching an adapter to said single stranded region.

Abstract: An assembly for use in an electrical power distribution system includes a housing that includes an interior space; an electrical apparatus in the interior space, the electrical apparatus including an electrical connection mechanism that is configured to move between at least two positions; an observation port through the housing, the observation port being configured to allow visual observation of the electrical connection mechanism in the interior space from an exterior of the housing; and an optical guide between the interior space and a light source. The light source is outside of the interior space and the optical guide is configured to deliver light from the light source to the interior space when the light source emits light.

Abstract: An improved article of footwear of the invention includes an upper, an adjustable closure system affixed to the upper, the closure system having a guide member having a first groove portion and a second groove portion, a fastening member positioned opposite the guide member and having at least two tensioning members, and removable cable assembly connecting the guide member and the fastening member, wherein the cable assembly extends sequentially through the first groove portion of the guide member, a first tensioning member of the fastening member, the second groove portion of the guide member, and a second tensioning member of the fastening member, a bottom secured to the upper, a stabilizing member positioned between the upper and the bottom, wherein the stabilizing member has a base portion and at least one of a lateral support portion and a medial support portion extending upwardly from opposing sides of the base portion.

Abstract: A toy construction system comprising toy construction elements comprising coupling members (20) for detachably interconnecting the toy construction elements to create spatial structures (40), the toy construction system comprises at least a first type of toy construction elements (10), the first type of toy construction elements can be coupled to each other, wherein that the first type of toy construction elements is configured to be detected by a touch screen (60), and when toy construction elements are coupled to each other so as to form a spatial structure, the toy construction elements of the first type define a touch point pattern recognizable by the touch screen.

Abstract: An assembly for use in an electrical power distribution system includes a housing that includes an interior space; an electrical apparatus in the interior space, the electrical apparatus including an electrical connection mechanism that is configured to move between at least two positions; an observation port through the housing, the observation port being configured to allow visual observation of the electrical connection mechanism in the interior space from an exterior of the housing; and an optical guide between the interior space and a light source. The light source is outside of the interior space and the optical guide is configured to deliver light from the light source to the interior space when the light source emits light.

Abstract: An improved article of footwear of the invention includes an upper, an adjustable closure system affixed to the upper, the closure system having a guide member having a first groove portion and a second groove portion, a fastening member positioned opposite the guide member and having at least two tensioning members, and removable cable assembly connecting the guide member and the fastening member, wherein the cable assembly extends sequentially through the first groove portion of the guide member, a first tensioning member of the fastening member, the second groove portion of the guide member, and a second tensioning member of the fastening member, a bottom secured to the upper, a stabilizing member positioned between the upper and the bottom, wherein the stabilizing member has a base portion and at least one of a lateral support portion and a medial support portion extending upwardly from opposing sides of the base portion.

Abstract: There is provided an optical fiber for providing increased sensitivity in sensing applications by increasing the Rayleigh backscatter coefficient of the fiber while maintaining tolerable levels of signal attenuation (e.g., less than 20% over 10 km). Such an optical fiber comprises a core, a first cladding layer and a second cladding layer. The core comprises at least one core dopant selected from the range of: germanium, phosphorus, aluminium, boron, fluorine. The at least one core dopant is used to increase the core refractive index and enhance the core Rayleigh backscatter coefficient. The first cladding layer comprises at least one dopant selected from: germanium, phosphorus, aluminium, boron, fluorine; wherein at least one first cladding layer dopant is used to reduce the first cladding layer refractive index. The signal attenuation generated in the fiber is less than 20% over 1 km.

Abstract: A toy construction system comprising toy construction elements comprising coupling members (20) for detachably interconnecting the toy construction elements to create spatial structures (40), the toy construction system comprises at least a first type of toy construction elements (10), the first type of toy construction elements can be coupled to each other, wherein that the first type of toy construction elements is configured to be detected by a touch screen (60), and when toy construction elements are coupled to each other so as to form a spatial structure, the toy construction elements of the first type define a touch point pattern recognizable by the touch screen.

Abstract: An insulated switchgear module is disclosed. In one example, the module comprises a vacuum interrupter, current exchange assembly, and end conductors disposed within an insulated housing. The insulated housing further comprises a tank containing an actuator mechanism for actuating the current exchange assembly. An insulating tray within the housing separates the vacuum interrupter from the components in the tank. The insulated tray has a shape that corresponds with the shape of the vacuum interrupter and the shape of the housing.