Abstract: A diffusion cell is described that includes a receiver compartment and a tightening ring intended to be positioned above the receiver compartment in such a way that a membrane sample, such as a sample of a skin, can be arranged between the receiver compartment and the tightening ring. The cell further includes means for tightening by rotation of the tightening ring on the receiver compartment. Uses of such a diffusion cell, in particular for evaluating the penetration capacity of a compound of interest contained in an aerosol formulation, are also described. These uses can be applicable in an occlusive patch or semi-occlusive patch or in a formulation under occlusive or semi-occlusive conditions in the skin. The uses can also be implemented to evaluate the capacity of an aerosol formulation, an occlusive or semi-occlusive patch or a formulation under occlusive or semi-occlusive conditions to deliver a compound of interest through the skin.

Abstract: A diffusion cell is described that includes a receiver compartment and a tightening ring intended to be positioned above the receiver compartment in such a way that a membrane sample can be arranged between the receiver compartment and the tightening ring. The cell further includes means for tightening by rotation of the tightening ring on the receiver compartment. Uses of such a diffusion cell, in particular for evaluating the penetration capacity of a compound of interest contained in an aerosol formulation, are also described. These uses can be applicable in an occlusive patch or semi-occlusive patch or in a formulation under occlusive or semi-occlusive conditions in the skin. The uses can also be implemented to evaluate the capacity of an aerosol formulation, an occlusive or semi-occlusive patch or a formulation under occlusive or semi-occlusive conditions to deliver a compound of interest through the skin.

Abstract: Pharmaceutical cream-gel compositions useful for the treatment of a variety of dermatological conditions, disorders and afflictions, in particular of rosacea, contain at least one avermectin compound active principle, and which also contain an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, the oily phase comprising oils having a melting point below 30° C. and being free of solid fats having a melting point above 30° C., formulated into a physiologically acceptable medium therefor.

Abstract: A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay, is described.

Abstract: A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described.

Abstract: Described is a composition for topical application in the form of a moisturizing composition including zinc gluconate and at least one UVA/UVB sunscreen as a moisturizering ingredient, and the use thereof as a cosmetic or a pharmaceutical product. The composition is intended for use in the treatment of acne.

Abstract: A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described.

Abstract: Topically applicable film-forming solutions, e.g., nail varnishes, useful for such dermatological applications as the prevention or treatment of nail psoriasis, contain, as active agents solubilized therein, vitamin D or derivative thereof and a corticosteroid, formulated into a topically applicable, physiologically acceptable medium therefor.

Abstract: A transungual patch/device useful for the treatment of onychomycosis includes: (i) a backing medium; and (ii) an adhesive matrix layer deposited thereon which contains (a) a thus effective amount of amorolfine active agent or derivative thereof essentially uniformly distributed therethrough, dissolved or dispersed in the adhesive, and (b) at least one absorption promoter for enhancing the absorption of the amorolfine or derivative into the nail onto which the patch/device is applied, the at least one absorption promoter comprising either exaltolide alone, or at least two such absorption promoters selected from among urea, N-acetylcysteine and lactic acid.

Abstract: The present invention relates to an anhydrous pharmaceutical composition for use in the treatment of psoriasis and other skin disorders, characterized in that it comprises an oleaginous ointment and, as active ingredient, a compound chosen from vitamin D and its derivatives, said active agent being in a solubilized form in said composition.

Abstract: A process for improving the penetration of at least one pharmaceutical active agent into the skin, including formulating at least one volatile silicone, a non-volatile oily phase and a pharmaceutically acceptable alcoholic vehicle herewith, and spraying the formulation onto the skin of an individual in need of such treatment.

Abstract: Topically applicable dermatological/cosmetic compositions suited for ungual/peri-ungual administration for the treatment of a variety of pathologies, including fungal pathologies, such as onychomycosis, contain (a) at least one biologically active agent (e.g., antifungal) and (b) at least two of the pro-penetrating agents selected from the group consisting of urea, an organic acid and an ethoxydiglycol, the at least two-pro-penetrating agents respectively being present in effective amounts as to synergistically improve the ungual/peri-ungual bioavailability of the at least one biologically active agent.

Abstract: Topically applicable, reduced-irritant dermatological/cosmetic compositions useful for the prevention/treatment of a variety of keratinization disorders, for example acne vulgaris, contain at least one naphthoic acid compound and an amount of benzoyl peroxide encapsulated in a polymeric system of porous particles for increasing cutaneous penetration of the at least one naphthoic acid compound, are formulated into topically applicable, physiologically acceptable media therefor.

Abstract: Topically applicable cosmetic/pharmaceutical compositions contain at least one retinoid and at least one anti-irritant compound selected from among is allantoin, divalent strontium salts, divalent zinc salts, monovalent sodium salts and the hydrated derivatives thereof, and are useful for the treatment and/or prevention of a dermatological condition or affliction related to a disorder of keratinization relating to cell differentiation and to cell proliferation, e.g. acne vulgaris.

Abstract: Stable, recrystallization-resistant invert emulsions, suited, e.g., for preventing/treating the signs of chronological or actinic skin aging and for preventing/treating atrophy of the skin or mucous membranes, comprise a cosmetically/therapeutically effective amount of DHEA and/or chemical and/or biological precursor or derivative thereof, such invert emulsions also comprising a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7.

Abstract: Topically applicable cosmetic/pharmaceutical compositions contain at least one retinoid and at least one anti-irritant compound selected from among the salts of 18?-glycyrrhetinic acid and derivatives thereof, and are useful for the treatment and/or prevention of a dermatological condition or affliction related to a disorder of keratinization relating to cell differentiation and to cell proliferation, e.g. acne vulgaris.

Abstract: Stable, topically applicable cosmetic/pharmaceutical skin depigmenting compositions contain at least one phenolic compound, at least one retinoid and at least one corticoid, and are formulated as aqueous-alcoholic gels in topically applicable, physiologically acceptable media therefor.

Abstract: Stable, anhydrous pharmaceutical compositions contain an organopolysiloxane elastomer and, as bioactive ingredient, at least one vitamin D compound in a solubilized form, and are useful for the topical treatment of psoriasis and other skin disorders/afflictions.

Abstract: Topically applicable film-forming solutions, e.g., nail varnishes, useful for such dermatological applications as the prevention or treatment of nail psoriasis, contain, as active agents solubilized therein, vitamin D or derivative thereof and a corticosteroid, formulated into a topically applicable, physiologically acceptable medium therefor.

Abstract: Cosmetic/pharmaceutical compositions comprising adapalene dissolved in an aqueous medium with cyclodextrin and/or derivatives thereof, notably as inclusion complexes therewith, are useful as cosmetics and for the therapeutic treatment, e.g., of acne.