Patents by Inventor Laurent Meijer

Laurent Meijer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purine inhibitors of protein kinases, G proteins and polymerases
    Publication number: 20050026938
    Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
    Type: Application
    Filed: August 30, 2004
    Publication date: February 3, 2005
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA a California corporation, Centre National De La Recherche Scientifique
    Inventors: Nathanael Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
  • Suppression of cyclin kinase activity for prevention and treatment of infections
    Publication number: 20040254094
    Abstract: The present invention relates to methods for use in treating or preventing infections. More particularly, the invention relates to methods for screening for modulators that inhibit cyclin-dependent kinase and the use of these putative inhibitors to control proliferation of a DNA virus that is dependent upon events associated with cell proliferation for replication. The DNA virus includes any of the herpesvirus family, and most particularly human cytomegalovirus.
    Type: Application
    Filed: October 10, 2001
    Publication date: December 16, 2004
    Applicants: The Trustees of University of Pennsylvania and Board of Regents, The University of Texas System
    Inventors: Thomas Albrecht, Laurent Meijer, Priscilla Schaffer, Luis Schang
  • Purine derivatives having, in particular, anti-proliferative properties and their biological uses
    Publication number: 20040235868
    Abstract: This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.
    Type: Application
    Filed: March 8, 2004
    Publication date: November 25, 2004
    Applicants: Centre National De La Recherche Scientifique (C.N.R.S.), Institute of Experimental Botany, Academy of Science of the Czech Republic
    Inventors: Laurent Meijer, Emile Bisagni, Michel Legraverend, Miroslav Strnad
  • Purine inhibitors of protein kinases, G proteins and polymerases
    Patent number: 6803371
    Abstract: The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: October 12, 2004
    Assignees: The Regents of the University of California, Centre National de la Recherche
    Inventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
  • Purine derivatives having, in particular, antiproliferative properties, and their biological uses
    Publication number: 20030186999
    Abstract: This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.
    Type: Application
    Filed: February 25, 2003
    Publication date: October 2, 2003
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.)
    Inventors: Laurent Meijer, Emile Bisagni, Michel Legraverend
  • Use of paullone derivatives for making medicines
    Publication number: 20030181439
    Abstract: The invention concerns the use for producing of GSK-3&bgr; inhibiting medicines from paullone derivatives. The invention is useful for treating pathologies involving GSK-3&bgr; and CDK5.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 25, 2003
    Inventors: Laurent Meijer, Conrad Kunick
  • Purine inhibitors of protein kinases, G proteins and polymerases
    Publication number: 20030176699
    Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
    Type: Application
    Filed: January 27, 2003
    Publication date: September 18, 2003
    Applicant: The Regents of the University of California
    Inventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
  • Purine inhibitors of protein kinases, G proteins and polymerases
    Patent number: 6617331
    Abstract: The invention provides compounds having the structure: where, R1 is a member selected from the group consisting of H and NH2; R2 is member selected from the group consisting of H, CO2H, OH and halogen; and R3 is a member selected from the group consisting of CO2H, NH2 and halogen. Also provided are methods of using the compounds and formulations containing the compounds.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: September 9, 2003
    Assignees: The Regents of the University of California, Centre National de la Recherche Scientifique
    Inventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
  • Fused azepinone cyclin dependent kinase inhibitors
    Patent number: 6610684
    Abstract: A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: August 26, 2003
    Assignees: The United States of America as represented by the Department of Health and Human Services, Centre National de la Recherche Scientifique
    Inventors: Daniel W. Zaharevitz, Rick P. Gussio, Ravi K. Jalluri, Edward A. Sausville, Conrad Kunick, Laurent Meijer
  • Purine inhibitors of protein kinases, G proteins and polymerases
    Publication number: 20030114672
    Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
    Type: Application
    Filed: May 1, 2001
    Publication date: June 19, 2003
    Inventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
  • Hymenialdisine or derivatives thereof in the manufacture of medicaments
    Publication number: 20030105075
    Abstract: The invention relates to the use of hymenialdisine or derivatives thereof of formula (I) in which R1 and R2, identical or different, represent H or Br, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in inhibiting acceptable salt thereof, in the manufacture of a medicament for use in inhibiting cycline dependent kineases, GSK-3&bgr; and casein kinase 1. Application for preventing and treating neurodegenerative disorders, diabetes, inflammatory pathologies and cancers.
    Type: Application
    Filed: October 4, 2002
    Publication date: June 5, 2003
    Inventor: Laurent Meijer
  • Methods of using chemical libraries to search for new kinase inhibitors
    Patent number: 6573044
    Abstract: The generation of selective inhibitors for specific protein kinases would provide new tools for analyzing signal transduction pathways and possibly new therapeutic agents. We have invented an approach to the development of selective protein kinase inhibitors based on the unexpected binding mode of 2,6,9-trisubstituted purines to the ATP binding site of human CDK2. The most potent inhibitor, purvalanol B (IC50=6 nM), binds with a 30-fold greater affinity than the known CDK2 inhibitor, flavopiridol. The cellular effects of this class of compounds were examined and compared to those of flavopiridol by monitoring changes in mRNA expression levels for all genes in treated cells of Saccharomyces cerevisiae using high-density oligonucleotide probe arrays.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: June 3, 2003
    Assignees: The Regents of the University of California, Affymetrix, Inc., Centre National de la Recherche Scientifique
    Inventors: Nathanael S. Gray, Peter Schultz, Lisa Wodicka, Laurent Meijer, David J. Lockhart
  • Method of treating and preventing acute neural lesions with substances that modulate the expression or function of a protein involved in the cell cycle and pharmaceutical preparations containing such substances
    Publication number: 20030060397
    Abstract: A method of treating or preventing non-apoptotic excitotoxic acute neural lesions in a patient including administering a therapeutically effective amount of a substance that modulates expression or the function of a protein involved in cell cycles, and a pharmaceutical preparation for treating or preventing non-apoptotic excitotoxic acute neural lesions including a therapeutically effective amount of a substance that modulates expression or the function of a protein involved in the cell cycle.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 27, 2003
    Applicant: Centre National de la Recherche Scientifique - CNRS and Inserm
    Inventors: Serge Timsit, Pauline Cavelier, Yehezkel Ben-Ari, Michel Khrestchatisky, Laurent Meijer
  • Suppression of cyclin kinase 2 activity for prevention and treatment of DNA viral infections
    Patent number: 6486166
    Abstract: An important aspect of the present invention is a method for inhibiting proliferation of a DNA virus dependent upon events associated with cell proliferation for replication. The DNA virus includes any of the herpesvirus family, and most particularly human cytomegalovirus. The method involves administering prophylactically or therapeutically effective amount of a cyclin-dependent kinase inhibitor to a patient or animal.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: November 26, 2002
    Assignee: Board of Regents, The University of Texas
    Inventors: Thomas Albrecht, Aubrey E. Thompson, Wade Bresnahan, Laurent Meijer
  • Purine derivatives having, in particular, antiproliferative properties, and their biological uses
    Publication number: 20020049218
    Abstract: This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.
    Type: Application
    Filed: November 8, 2001
    Publication date: April 25, 2002
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.)
    Inventors: Laurent Meijer, Emile Bisagni, Michel Legraverend
  • Fused azepinone cyclin dependent kinase inhibitors
    Publication number: 20020042412
    Abstract: A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described.
    Type: Application
    Filed: December 14, 2000
    Publication date: April 11, 2002
    Inventors: Daniel W. Zaharevitz, Rick P. Gussio, Ravi K. Jalluri, Edward A. Sausville, Conrad Kunick, Laurent Meijer
  • Purine derivatives having, in particular, antiproliferative properties, and their biological uses
    Patent number: 6316456
    Abstract: This invention provides 2-, 6, and 9-substituted purine derivatives having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: November 13, 2001
    Assignees: Centre National de la Recherche Scientifique, Institute of Experimental Botany
    Inventors: Laurent Meijer, Emile Bisagni, Michel Legraverend
  • Purine inhibitors of protein kinases, G proteins and polymerases
    Patent number: 6255485
    Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: July 3, 2001
    Assignees: The Regents of the University of California, Centre National de la Recherche Scientifique
    Inventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer