Abstract: The present invention relates to a method of enriching for membranous microvesicles relative to the cellular population in a biological sample. More particularly, there is provided a method for enriching for exosomes from plasma. In a related aspect, there is provided a method of reducing the concentration of cellular and cellular derived molecules in a biological sample. Still further, the present invention provides methods for selectively isolating mRNA subpopulations from exosomes. Yet further, there are provided methods of amplifying exosome derived RNA. The method of the present invention is useful in a range of applications including, but not limited to, diagnostic, prognostic, therapeutic, research and development applications, to the extent that the enrichment of exosomes is required.

Abstract: A wireless communication network serves data content to a wireless user device. An access wireless relay wirelessly receives a user request for the data content from the wireless user device. The access wireless relay wirelessly transfers the data content to the wireless user device when it stores the data content. When the access wireless relay does not store the data content, it transfers content requests having a Time-To-Live (TTL). Serving wireless relays receive the content requests during the TTL. The serving wireless relays transfer the data content to the access wireless relay if they store the data content. The serving wireless relays forward the content requests with the TTL when they do not store the data content. Terminating wireless relays receive the content requests after the TTL. The terminating wireless relays stop forwarding the content requests.

Abstract: The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset and/or progression of a large intestine or breast neoplasm, such as an adenoma or adenocarcinoma. The DNA methylation status of the present invention is useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal or breast neoplasms, such as colorectal or breast adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in DNA methylation of one or more nucleic acid molecules.

Abstract: The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset and/or progression of a large intestine or breast neoplasm, such as an adenoma or adenocarcinoma. The DNA methylation status of the present invention is useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal or breast neoplasms, such as colorectal or breast adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in DNA methylation of one or more nucleic acid molecules.

Abstract: Disclosed are nucleic acid, RNA, and protein expression profiles which are indicative of the onset, predisposition to the onset and/or progression of a large intestine neoplasm. More particularly disclosed are nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a colorectal neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenomas and adenocarcinomas. Further disclosed are methods of screening a subject for the onset, predisposition to the onset and/or progression of a large intestine neoplasm by screening for modulation in the expression profile of the disclosed nucleic acid molecule markers.

Abstract: A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

Abstract: Examples disclosed herein provide systems, methods, and software to dynamically provide carrier aggregation to wireless communication devices. In one example, a method of operating an eNodeB includes exchanging first wireless communication signals with a wireless communication device using a first carrier aggregation configuration. The method further provides identifying a request from the wireless communication device for a modified quality of service, and determining a second carrier aggregation configuration based on the request. The method also includes exchanging second wireless communication signals with the wireless communication device using the second carrier aggregation configuration.

Abstract: A system, cable, and method for wireline operations are disclosed, in which a wireline cable may include one or more electrical wire having a compact stranded conductor, a first dielectric layer formed about the first electrical wire, and a strength member. The compact strands provide for increasing conductor size, increasing dielectric layer thickness, increasing armor size, and/or decreasing cable outer diameter. These parameters may be varied and optimized to provide specific wireline cable designs for particular wireline purposes. As compared to a conventional wireline cable employing uncompacted stranded conductors, the electrical resistance of the wireline cable may be lowered, the capacitance may be lowered, the operating temperature may be lowered, the outer diameter and weight may be lowered, and/or the tensile strength may be increased.

Abstract: Systems and methods for the application of distributed ledgers for network payments as financial exchange settlement and reconciliation are disclosed. In one embodiment, a method for processing network payments using a distributed ledger may include: (1) a payment originator initiating a payment instruction to a payment beneficiary; (2) a payment originator bank posting and committing the payment instruction to a distributed ledger on a peer-to-peer network; (3) the payment beneficiary bank posting and committing the payment instruction to the distributed ledger on a peer-to-peer network; and (4) the payment originator bank validating and processing the payment through a payment originator bank internal system and debiting an originator account.

Abstract: The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.

Abstract: A method of characterizing a monolithic tunable mid-infrared laser including a heterogeneous quantum cascade active region together with a least first and a second tunable integrated distributed feedback gratings, the method including operating the laser while tuning the first grating through its full tuning range, while holding the reflectivity function of the second grating constant, then operating the laser while tuning the second grating through its full tuning range, while holding the reflectivity function of the first grating constant.

Abstract: One embodiment is directed towards a method of navigating a body. The method includes determining a respective measured direction of each of a plurality of celestial objects with respect to the body based on an output of one or more star tracking sensors mounted to the body. Calculating an expected direction of at least one of the plurality of celestial objects with respect to the body based on a current navigation solution for the body. Calculating an updated navigation solution for the body based on the expected direction of the at least one celestial object, the measured direction of the plurality of celestial objects, and an output of one or more inertial sensors mounted to the body.

Abstract: The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.

Abstract: A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

Abstract: A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

Abstract: A navigation system comprises a GNSS receiver that receives GNSS signals on multiple tracking channels, an INS that generates inertial data, and a processor. A micro jump detection and correction module comprises an oscillator micro jump detector that monitors estimates of C/N0 in all tracking channels, and detects a micro-jump event when there is an abrupt decrease of C/N0 in all tracking channels. An offsets module defines a plurality of carrier NCO command offsets to search over signal Dopplers in all available tracking channels after the micro jump event is detected, and sends the carrier NCO command offsets to the GNSS receiver to be added to nominal carrier NCO commands. The micro jump detector selects a tracking channel with the highest C/N0 after carrier NCO command offsets are added to nominal carrier NCO commands, computes corrections for clock error estimates, and sends the corrections for the clock error estimates to a GNSS/inertial Kalman filter.

Abstract: Examples disclosed herein provide systems, methods, and software to dynamically provide carrier aggregation to wireless communication devices. In one example, a method of operating an eNodeB includes exchanging first wireless communication signals with a wireless communication device using a first carrier aggregation configuration. The method further provides identifying a request from the wireless communication device for a modified quality of service, and determining a second carrier aggregation configuration based on the request. The method also includes exchanging second wireless communication signals with the wireless communication device using the second carrier aggregation configuration.

Abstract: One embodiment is directed towards a method of navigating a body. The method includes determining a respective measured direction of each of a plurality of celestial objects with respect to the body based on an output of one or more star tracking sensors mounted to the body. Calculating an expected direction of at least one of the plurality of celestial objects with respect to the body based on a current navigation solution for the body. Calculating an updated navigation solution for the body based on the expected direction of the at least one celestial object, the measured direction of the plurality of celestial objects, and an output of one or more inertial sensors mounted to the body.

Abstract: A method of characterizing a monolithic tunable mid-infrared laser including a heterogeneous quantum cascade active region together with a least first and a second tunable integrated distributed feedback gratings, the method including operating the laser while tuning the first grating through its full tuning range, while holding the reflectivity function of the second grating constant, then operating the laser while tuning the second grating through its full tuning range, while holding the reflectivity function of the first grating constant.

Abstract: A monolithic tunable mid-infrared laser has a wavelength range within the range of 3-14 ?m and comprises a heterogeneous quantum cascade active region together with at least a first integrated grating. The heterogeneous quantum cascade active region comprises at least one stack, the stack comprising two, desirably at least three differing stages. Methods of operating and calibrating the laser are also disclosed.