Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.

Abstract: The present invention relates generally to a nucleic acid molecule, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a large intestine neoplasm. More particularly, the present invention is directed to a nucleic acid molecule, the expression profiles of which are indicative of the onset and/or progression of a colorectal neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenomas and adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a large intestine neoplasm by screening for modulation in the expression profile of said nucleic acid molecule markers.

Abstract: Embodiments of the present disclosure bring a wavelength conversion device into close proximity with a laser source to eliminate the need for coupling optics, reduce the number of package components, and reduce package volume. According to one embodiment of the present disclosure, an optical package is provided comprising a laser diode chip and a clad metal substrate. The clad metal substrate comprises a clad metal region that is mechanically coupled to a base metal region. The laser diode chip is coupled to the clad metal region. The clad metal region comprises a clad metal material having a thermal conductivity that is greater than a thermal conductivity of the base metal material. The clad metal region further comprises a coefficient of thermal expansion that is approximately equal to a coefficient of thermal expansion of the base metal material and is greater than a coefficient of thermal expansion of the laser diode chip.

Abstract: Downhole cables are described that are configured to protect internal structures that may be detrimentally impacted by exposure to the downhole environment, by protecting such structures by at least two protective layers. In some examples, the structures to be protected may be housed in a protective tube housed within the protective outer sheath. The described configuration enables the use of structures such as polymer fibers in the cables for strength and load-bearing capability by protecting the fibers, by multiple protective layers, from exposure to gases or fluids within a wellbore.

Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.

Abstract: Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof.

Abstract: Particular embodiments of the present disclosure bring an SHG crystal, or other type of wavelength conversion device, into close proximity with a laser source to eliminate the need for coupling optics, reduce the number of package components, and reduce package volume. According to one embodiment of the present disclosure, an optical package is provided comprising a laser source subassembly comprising a laser base and a wavelength conversion device subassembly comprising a converter base. The bonding interface of the laser base is bonded the complementary bonding interface of the converter base such that the laser output face can be proximity-coupled to the converter input face at an predetermined interfacial spacing x. Additional embodiments are disclosed and claimed.

Abstract: Particular embodiments of the present disclosure bring an SHG crystal, or other type of wavelength conversion device, into close proximity with a laser source to eliminate the need for coupling optics, reduce the number of package components, and reduce package volume. According to one embodiment of the present disclosure, an optical package is provided comprising a laser source and a wavelength conversion device. The laser source is positioned such that the output face of the laser source is proximity-coupled to a waveguide portion of the input face of the wavelength conversion device. The input face of the wavelength conversion device comprises an ?-cut facet and ?-cut facet. The ?-cut facet of the input face is oriented at a horizontal angle ?, relative to the waveguide of the wavelength conversion device to permit proximity coupling of the output face of the laser source and the input face of the wavelength conversion device.

Abstract: The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C3-C8 cyclic carbonyl compound and a C1-C8 amide compound, said amide compound comprising at least one N—H moiety. In addition the present invention provides a method of preparing a composite membrane comprising contacting under interfacial polymerization conditions an organic solution comprising a polyacid halide with an aqueous solution comprising a polyamine, said contacting being carried out on a surface of a porous base membrane, said organic solution further comprising a C3-C8 cyclic carbonyl compound, said aqueous solution comprising a C1-C8 amide compound, said amide compound comprising at least one N—H moiety.

Abstract: The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.

Abstract: Metallization patterns are provided to reduce the probability of chip fracture in semiconductor lasers. According to one embodiment disclosed herein, the pad edges of a metallization pattern extend across a plurality of crystallographic planes in the laser substrate. In this manner, cracks initiated at any given stress concentration would need to propagate across many crystallographic planes in the substrate to reach a significant size. Additional embodiments of the present disclosure relate to the respective geometries and orientations of adjacent pairs of contact pads. Still further embodiments are disclosed and claimed.

Abstract: A testing device for the identification of an analyte of interest in a sample, comprises a housing having an internal recess (14); a sample collection device (19) and at least one insertable testing element (20); the housing being adapted to receive the sample collection device in the internal recess therein and to shield a sample collected on the sample collection device, the housing also being adapted to receive the or each insertable testing element such that, on insertion of the testing element into the housing, the testing element is in liquid conductive communication with a sample collected on the sample collection device.

Abstract: A catheter shaft with an improved manifold bond and methods for making and using the same. The catheter shaft may include a sleeve disposed, for example, near its proximal end. The sleeve may include a first layer that is attached to the catheter shaft and a second layer to which a hub or manifold may be attached.

Abstract: A catheter shaft with an improved manifold bond and methods for making and using the same. The catheter shaft may include a sleeve disposed, for example, near its proximal end. The sleeve may include a first layer that is attached to the catheter shaft and a second layer to which a hub or manifold may be attached.

Abstract: An optical package includes a semiconductor laser, a wavelength conversion device and a MEMS-actuated mirror oriented on a base module to form a folded optical pathway between an output of the semiconductor laser and an input of the wavelength conversion device. An optical assembly is located in a mechanical positioning device and the mechanical positioning device is disposed on the base module along the optical pathway such that the beam of the semiconductor laser passes through the optical assembly, is reflected by the MEMS-actuated mirror back through the optical assembly and into the waveguide portion of the wavelength conversion device. The MEMS-actuated mirror is operable to scan the beam of the semiconductor laser over the input of the wavelength conversion device. The optical assembly may be adjusted along the optical pathway with the mechanical positioning device to focus the beam into the waveguide portion of the wavelength conversion device.

Abstract: Glass-based micropositioning systems and methods are disclosed. The micropositioning systems and methods utilize microbumps (40) formed in a glass substrate (12 or 100). The microbumps are formed by subjecting a portion of the glass substrate to localized heating, which results in local rapid expansion of glass where the heat was applied. The height and shape of the microbumps depend on the type of glass substrate and the amount and form of heat delivered to the substrate. The microbumps allow for active or passive micropositioning of optical elements, including planar waveguides and optical fibers. Optical assemblies formed using microbump micropositioners are also disclosed.

Abstract: A method of preparing and displaying a cumulative presentation and a presentation system are provided. A listing of available individual presentation files is provided through a user interface. Each of the presentation files comprises a plurality of presentation slides. A user is queried through the user interface to select presentation files from the available individual presentation files for inclusion in a cumulative presentation in a selected presentation order. A listing of presentation files selected by the user is displayed in the user interface. In response to a first command received from the user, a first slide from a first presentation from the cumulative presentation is provided to a display device for display thereon. In response to a second command received from the user, a second slide from the cumulative presentation is provided to the display device for display thereon.

Abstract: A method of preparing and displaying a cumulative presentation and a presentation system are provided. A listing of available individual presentation files is provided through a user interface. Each of the presentation files comprises a plurality of presentation slides. A user is queried through the user interface to select presentation files from the available individual presentation files for inclusion in a cumulative presentation in a selected presentation order. A listing of presentation files selected by the user is displayed in the user interface. In response to a first command received from the user, a first slide from a first presentation from the cumulative presentation is provided to a display device for display thereon. In response to a second command received from the user, a second slide from the cumulative presentation is provided to the display device for display thereon.

Abstract: A speaker housing for mounting at least one speaker therein is disclosed. The speaker housing includes a speaker enclosure sealed to a speaker cover. The speaker enclosure includes an opening for sealing a connector attached to a crossover printed circuit board assembly thereto. The connector protrudes through the opening in the speaker enclosure while the printed circuit board to which it is attached compresses a compressible gasket against a wall surrounding the opening in the speaker enclosure, sealing the connector thereto. The chassis wiring is coupled to the connector providing an inexpensive sealed interface between the electronics chassis and the crossover board assembly.

Abstract: The present invention relates to lensed fiber stub assemblies and optical and optoelectronic packages including them. The fiber stub assemblies include a section of lensed fiber having a lensed end having a lens face, and a distal end having an endface, a lens alignment ferrule affixed to and holding the lensed end of the lensed fiber, and a package attachment ferrule having a distal endface and an exterior surface, the package attachment ferrule affixed to and holding the distal end of the lensed fiber. The lensed fiber stub assemblies of the present invention allow for hermetic packaging of optical and optoelectronic devices, good manufacturing throughput, facile package connectorization, acceptable device thermal performance, and ease of alignment in the packaging process.